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Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and they play fundamental roles in immune regulation. Here we introduce an integrated algorithm, ImmLnc, for identifying lncRNA regulators of immune-related pathways. We comprehensively chart the landscape of lncRNA regulation in the immunome across 33 cancer types and show that cancers with similar tissue origin are likely to share lncRNA immune regulators. Moreover, the immune-related lncRNAs are likely to show expression perturbation in cancer and are significantly correlated with immune cell infiltration. ImmLnc can help prioritize cancer-related lncRNAs and further identify three molecular subtypes (proliferative, intermediate, and immunological) of non-small cell lung cancer. These subtypes are characterized by differences in mutation burden, immune cell infiltration, expression of immunomodulatory genes, response to chemotherapy, and prognosis. In summary, the ImmLnc pipeline and the resulting data serve as a valuable resource for understanding lncRNA function and to advance identification of immunotherapy targets. In cancer, long noncoding RNAs (lncRNAs) can regulate immune-related pathways. Here, the authors present ImmLnc, an algorithm that can help prioritise immune-related lncRNAs in cancer immunotherapy research

Mining-induced surface cracks are critical indicators of overburden deformation and pose significant threats to ground stability and mine safety. However, their fine-scale geometry and complex background interference make automated extraction challenging. This study proposes an improved DRA-UNet model for high-precision crack detection from UAV orthophotos. The network integrates residual learning, a dual-attention mechanism (DAM), and an atrous spatial pyramid pooling (ASPP) module to enhance feature representation, suppress noise, and capture multi-scale contextual information. A complete analytical framework is established by coupling crack segmentation with skeleton extraction and quantitative geometric characterization, enabling fine-scale morphological analysis. Experimental results show that the proposed method outperforms representative segmentation models, achieving an F1-score of 71.60% and MIoU of 70.00% on a mining-area UAV dataset. Ablation studies verify the effectiveness of each module, while external validation on the Crack500 dataset demonstrates strong cross-scene generalization (F1 = 85.32%, MIoU = 83.69%). Geometric analysis reveals pronounced right-skewed distributions of crack length, width, and area, with rectangularity decreasing as crack length increases. Spatial results indicate higher crack density and complexity near working-face boundaries. Overall, the proposed framework provides a robust and fully automated solution for mining-induced crack detection and morphological analysis.

Smoking cessation programmes delivered via mobile phone text messaging show increases in self-reported quitting in the short term. We assessed the effect of an automated smoking cessation programme delivered via mobile phone text messaging on continuous abstinence, which was biochemically verified at 6 months. In this single-blind, randomised trial, undertaken in the UK, smokers willing to make a quit attempt were randomly allocated, using an independent telephone randomisation system, to a mobile phone text messaging smoking cessation programme (txt2stop), comprising motivational messages and behavioural-change support, or to a control group that received text messages unrelated to quitting. The system automatically generated intervention or control group texts according to the allocation. Outcome assessors were masked to treatment allocation. The primary outcome was self-reported continuous smoking abstinence, biochemically verified at 6 months. All analyses were by intention to treat. This study is registered, number ISRCTN 80978588. We assessed 11 914 participants for eligibility. 5800 participants were randomised, of whom 2915 smokers were allocated to the txt2stop intervention and 2885 were allocated to the control group; eight were excluded because they were randomised more than once. Primary outcome data were available for 5524 (95%) participants. Biochemically verified continuous abstinence at 6 months was significantly increased in the txt2stop group (10·7% txt2stop vs 4·9% control, relative risk [RR] 2·20, 95% CI 1·80–2·68; p<0·0001). Similar results were obtained when participants that were lost to follow-up were treated as smokers (268 [9%] of 2911 txt2stop vs 124 [4%] of 2881 control [RR 2·14, 95% CI 1·74–2·63; p<0·0001]), and when they were excluded (268 [10%] of 2735 txt2stop vs 124 [4%] of 2789 control [2·20, 1·79–2·71; p<0·0001]). No significant heterogeneity was shown in any of the prespecified subgroups. The txt2stop smoking cessation programme significantly improved smoking cessation rates at 6 months and should be considered for inclusion in smoking cessation services. UK Medical Research Council, Primary Care Research Networks.

The rapid development of wearable, highly integrated, and flexible electronics has stimulated great demand for on-chip and miniaturized energy storage devices. By virtue of their high power density and long cycle life, micro-supercapacitors (MSCs), especially those with interdigital structures, have attracted considerable attention. In recent years, tremendous theoretical and experimental explorations have been carried out on the structures and electrode materials of MSCs, aiming to obtain better mechanical and electrochemical properties. The high-performance MSCs can be used in many fields, such as energy storage and medical assistant examination. Here, this review focuses on the recent progress of advanced MSCs in fabrication strategies, structural design, electrode materials design and function, and integrated applications, where typical examples are highlighted and analyzed. Furthermore, the current challenges and future development directions of advanced MSCs are also discussed.

Background and objectives Non-alcoholic fatty liver disease (NAFLD) and urinary incontinence (UI) are both highly prevalent and age-related diseases. Nevertheless, the link between NAFLD and UI is unclear. Hence, the study was designed to evaluate the association between the NAFLD and UI (including UI types) in a nationally representative sample of United States (US) female adults. Methods We conducted this study used data from U.S. female adults in the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 (pre-pandemic) cycles. The diagnosis of NAFLD is based on Vibration controlled transient elastography (VCTE) and absence of know liver diseases and significant alcohol consumption. The diagnosis and types of UI were assessment using a self-report questionnaire. Multivariable logistic regression models were used to analyze the association between NALFD and UI. Stratified analyses based on age, obesity, race, educational level, married status, PIR, and smoking status were conducted. Results Of the 2149 participants, the mean (95% CI) age was 53.9 (52.7–55.0), 686 (61.1%) were Non-Hispanic White. UI was significantly more common in participants with NAFLD [490 (64.7%)] than those without NAFLD [552 (44.9%)]. Adjusted for age, race/ethnicity, marital status, educational level, family poverty income ratio (PIR) status, alanine aminotransferase (ALT), aspartate aminotransferase (AST), smoking status, obesity, type 2 diabetes mellitus (T2DM), hypertension and insulin resistance (IR) in a multivariable logistic regression model, NALFD were associated with UI [OR: 1.93, 95%CI 1.23–3.02, P  = 0.01] and urge UI [OR: 1.55, 95%CI 1.03–2.33, P  = 0.03], while patients with NAFLD did not show an increased odds in stress UI and mixed UI when compared with those without NAFLD subject ( P  > 0.05). In the subgroup analyses, NAFLD remained significantly associated with UI, particularly among those participants without obesity (OR: 2.69, 95% CI 1.84-4.00) and aged ≥ 60 years (OR: 2.20, 95% CI 1.38–3.51). Conclusions Among US female adults, NAFLD has a strong positive correlation with UI. Given that NAFLD is a modifiable disease, these results may help clinicians to target female patients with NAFLD for treatments and interventions that may help prevent the occurrence of UI and reduce the symptoms of UI.

The developmental phase of the fault deformation zone denotes the zone of weak deformation (with strong concealment) that evolves within the sedimentary cover of the basin. Recent studies have unveiled the objectively existing tectonic phenomenon of weakly deformed tectonic belts within the sedimentary basin cover, closely intertwined with oil and gas accumulation. To elucidate the deformation intensity and hydrocarbon accumulation scale within the cap cover deformation zone, a pivotal concern in oil and gas geology, this study focuses on the Dongying Sag. The structural physical simulation experiment method, incorporating variable caprock thickness and variable shear strength, is employed to scrutinize the impact of basement fault strike-slip activity on the development of faults in the sedimentary caprock of the basin and dyed oil is charged. In conjunction with sag examples, Early R shear single-channel migration-isolated aggregation, Early and mid-term R shear main channel migration-geese and beaded aggregation, P shear main channel migration-intermittent zonal aggregation, Full channel migration-continuous belt aggregation accumulation models of basement faults are established. It is emphasized that the R shear pressurized deformation section and the R and P shear intersection section in the deformation zone are favorable target areas for oil and gas exploration.

The performance consistency of an RF MEMS switch matrix is a crucial metric that directly impacts its operational lifespan. An improved crossbar-based RF MEMS switch matrix topology, SR-Crossbar, was investigated in this article. An optimized port configuration scheme was proposed for the RF MEMS switch matrix. Both the utilization probability of individual switch nodes and the path lengths in the switch matrix achieve their best consistency simultaneously under the proposed port configuration scheme. One significant advantage of this scheme lies in that it only adjusts the positions of the input and output ports, with the topology and individual switch nodes kept unchanged. This grants it a high level of generality and feasibility and also introduces an additional degree of freedom for optimizations. In this article, a universal utilization probability function of single nodes was constructed and an optimization objective function for the SR-Crossbar RF MEMS switch matrix was formulated, which provide a convenient approach to directly solving the optimized port configuration scheme for practical applications. Simulations to demonstrate the optimized dynamic and static consistencies were conducted. For an 8 × 8 SR-Crossbar switch matrix, the standard deviations of contact resistances of 128 units and losses of all 64 paths decreased from 1.00 and 0.42 to 0.51 and 0.23, respectively. These results aligned closely with theoretical calculations derived from the proposed model.

The Zhugongtang lead-zinc deposit is a super-large lead-zinc deposit controlled by the fault-fold structure in the Western Guizhou, China. In this paper, the complex migration process of ore-bearing fluid in fault-fold structures is reproduced by numerical simulation based on a multi-field coupled framework combining thermodynamics and fluid mechanics. The results show that ore-bearing fluid first migrates vertically rapidly along the fault and then transfers horizontally along the stratum to the SE flank of the fold. Negative pressure anomalies appear at the narrowing position in the deep part of the fault and at the intersection of faults and folds. The spatial distribution of Zn 2+ is related to the known mineralization distribution. Under the influence of heat flow field and pressure, ore-bearing fluid tends to the abnormal area of negative stress. Comparative experiments with different interlimb angle show that for smaller interlimb angle, mineralization tends to occur in faults, and conversely, mineralization tends to occur in strata. This is consistent with the structural control of mineralization observed in other deposits in northwestern Guizhou. This research provides a new insight into the understanding of fault ore control model.

Challenges in direct catalytic oxidation of biomass-derived aldehyde and alcohol into acid with high activity and selectivity hinder the widespread biomass application. Herein, we demonstrate that a Pd/Ni(OH) 2 catalyst with abundant Ni 2+ -O-Pd interfaces allows electrooxidation of 5-hydroxymethylfurfural to 2, 5-furandicarboxylic acid with a selectivity near 100 % and 2, 5-furandicarboxylic acid yield of 97.3% at 0.6 volts (versus a reversible hydrogen electrode) in 1 M KOH electrolyte under ambient conditions. The rate-determining step of the intermediate oxidation of 5-hydroxymethyl-2-furancarboxylic acid is promoted by the increased OH species and low C–H activation energy barrier at Ni 2+ -O-Pd interfaces. Further, the Ni 2+ -O-Pd interfaces prevent the agglomeration of Pd nanoparticles during the reaction, greatly improving the stability of the catalyst. In this work, Pd/Ni(OH) 2 catalyst can achieve 100% 5-hydroxymethylfurfural conversion and >90% 2, 5-furandicarboxylic acid selectivity in a flow-cell and work stably over 200 h under a fixed cell voltage of 0.85 V. Catalytic oxidation of biomass-derived aldehydes and alcohols into acids is challenging due to low activity and selectivity. Here the authors report a Pd/Ni(OH) 2 electrocatalyst with abundant Ni 2+ -O-Pd interfaces that enables efficient electrooxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid with high selectivity and product yield.

It is very challenging to fabricate spherical refractory material powders for additive manufacturing (AM) because of their high melting points and complex compositions. In this study, a novel technique, freeze-dry pulsated orifice ejection method (FD-POEM), was developed to fabricate spherical MoSiBTiC particles without a melting process. Elemental nanopowders were dispersed in water to prepare a high-concentration slurry, which was subsequently extruded from an orifice by diaphragm vibration and frozen instantly in liquid nitrogen. After a freeze-drying process, spherical composite particles with arbitrary composition ratios were obtained. The FD-POEM particles had a narrow size range and uniform elemental distribution. Mesh structures were formed within the FD-POEM particles, which was attributed to the sublimation of ice crystals. Furthermore, owing to their spherical morphology, the FD-POEM particles had a low avalanche angle of 42.6°, exhibiting good flowability. Consequently, the combination of FD-POEM and additive manufacturing has great potential for developing complex refractory components used in industrial applications.