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Promoting the integrated development of rural industries represents a crucial pathway for accelerating the modernization of the entire industrial chain and consolidating and enhancing agricultural resilience. This study constructs provincial-level panel data for China spanning 2012–2022 and employs a multidimensional, visualization-based, and spatial research paradigm to comprehensively examine the impact effects and mechanisms through which rural industrial integration empowers agricultural resilience in China. The findings reveal that, first, rural industrial integration can effectively enhance agricultural resilience levels, with stable economic returns and diversified functional development serving as key pathways for improving agricultural resilience. Second, the eastern and western regions have unleashed agricultural resilience potential through superior policy and environmental advantages, while the relatively homogeneous grain structure and path dependence in the central and northeastern regions have prevented agricultural industrial integration from effectively achieving expected outcomes. Third, structural rationalization has improved resource allocation efficiency, but industrial structure advancement and industrial structure sophistication have actually diminished the enhancement effects on agricultural resilience. Fourth, urbanization has led to adverse resource competition, reducing the positive impact of rural industrial integration on agricultural resilience levels. Fifth, the enhancement of agricultural resilience through rural industrial integration demonstrates geographically-distant resource spillover effects to neighboring regions. This research provides an important theoretical framework and practical paradigm for global agricultural transformation, offering particularly significant strategic guidance for developing countries in building resilient agricultural systems, addressing climate change impacts, and ensuring food security.

The role of mesoscale cellular convection (MCC) in regulating aerosol‐induced cloud brightness remains unaddressed. Using 7 years of satellite‐based observations of cloud water adjustment to aerosol‐induced perturbations for closed MCCs across different sizes (8, 16, 32, and 64 km) over the North Atlantic Ocean, we show that MCC cell‐size plays a nontrivial role in regulating aerosol‐induced cloud brightness via cloud water adjustment. In cells that are primarily non‐precipitating, the adjustment in small‐scale MCCs can be 10 times more negative than in large‐scale MCCs, consistent with stronger evaporation via cloud top entrainment. Consequently, the response of cloud brightness is significantly stronger for large‐scale MCCs. We also find notable intra‐cell co‐variability between cloud liquid water path (LWP) and drop concentration (Nd) within MCCs that varies with cell size. Erroneously considering such co‐variability as a LWP response to Nd can lead to a significant positive bias, especially for small scale MCCs. Plain Language Summary Low clouds over the ocean often exhibit organized patterns with characteristic cell sizes but the effect of this organization on cloud‐aerosol interactions is not yet fully understood. Here we group 7 years of satellite‐measured low cloud cells over the North Atlantic Ocean by their cell size to investigate how cell size influences the response of cloud water and cloud brightness to cloud droplet number concentration perturbations. Large‐scale cells are found to have less efficient depletion of cloud water in response to increasing drop number compared to small‐scale cells. This leads to nearly an order of magnitude stronger increase in cloud brightness with increasing drop number. Furthermore, we show that the spatial distributions of liquid water path and drop concentration vary with cell‐size. Mistakenly assuming the local correlation between cloud water path and drop concentration to be a causal response can cause a significant positive error, especially for small‐scale cells. Key Points Mesoscale cellular convection (MCC) cell‐size significantly regulates aerosol‐induced cloud albedo via its effect on cloud water adjustment The aerosol‐induced cloud water adjustment in small‐scale MCCs can be 10 times more negative than in large‐scale MCCs We find notable intra‐cell co‐variability between cloud liquid water path and drop concentration within MCCs that varies with cell size

We present for the first time within the cloud physics context, the application of wavelet phase coherence analysis to disentangle counteracting physical processes associated with the lead‐lag phase difference between cloud‐proxy liquid water path (LWP) and aerosol‐proxy cloud droplet number concentration (Nd) in an Eulerian framework using satellite‐based observations and climate model outputs. This approach allows us to identify the causality and dominant adjustment timescales governing the correlation between LWP and Nd. Satellite observations indicate a more prevalent positive correlation between daytime LWP and Nd regardless of whether LWP leads or lags Nd. The positive cloud water response, associated with precipitation processes, typically occurs within 1 hr, while the negative response resulting from entrainment drying, usually takes 2–4 hr. CAM6 displays excessively rapid negative responses along with overly strong negative cloud water response and insufficient positive response, leading to a more negative correlation between LWP and Nd compared to observations.

SEPT9 methylation has been closely linked to breast cancer, yet its role in differentiating disease stages remains unclear. In particular, Few studies previously have examined differences in SEPT9 methylation between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC), or among DCIS lesions of varying nuclear grades. This study investigated SEPT9 methylation across 105 breast cancer cases, classified into pure DCIS, DCIS with invasive components (DCIS-INV), IDC alone, and metastatic breast cancer (MBC). Methylation levels were measured using real-time PCR, and in vitro experiments were conducted using MCF-7 and T47D cell lines treated with decitabine to explore the relationship between methylation and microtubule stability. SEPT9 methylation was significantly elevated in cancer cells compared to normal breast epithelium, with positivity rates of 90.6% in DCIS-INV, 77.8% in IDC, and 79.2% in MBC, versus only 18.2% in pure DCIS. SEPT9 methylation was negtive in low-grade DCIS and positive in 28.6% of intermediate- to high-grade cases. Positive methylation was significantly associated with high Ki-67 expression and lymph node metastasis ( P  < 0.05), but showed no correlation with age, menopausal status, tumor size, or hormone receptor status. Additionally, decitabine treatment induced a reduction in SEPT9 methylation levels, which affects microtubule stability, suggesting a potential mechanistic link to tumor invasion. These findings indicate that SEPT9 methylation is a promising biomarker for distinguishing invasive breast cancer from DCIS and for identifying high-risk DCIS lesions with greater potential for progression.

Background The associations of frailty with all-cause and cause-specific mortality remain unclear. Therefore, we performed this meta-analysis to fill this gap. Methods We searched the PubMed and Embase databases through June 2022. Prospective cohort studies or clinical trials examining frailty were evaluated, and the multiple adjusted risk estimates of all-cause and cause-specific mortality, such as death from cardiovascular disease (CVD), cancer, respiratory illness, dementia, infection, and coronavirus disease 2019 (COVID-19), were included. A random effects model was used to calculate the summary hazard ratio (HR). Results Fifty-eight studies were included for the qualitative systematic review, of which fifty-six studies were eligible for the quantitative meta-analysis, and the studies included a total of 1,852,951 individuals and more than 145,276 deaths. Compared with healthy adults, frail adults had a significantly higher risk of mortality from all causes (HR 2.40; 95% CI 2.17–2.65), CVD (HR 2.64; 95% CI 2.20–3.17), respiratory illness (HR 4.91; 95% CI 2.97–8.12), and cancer (HR 1.97; 95% CI 1.50–2.57). Similar results were found for the association between prefrail adults and mortality risk. In addition, based on the studies that have reported the HRs of the mortality risk per 0.1 and per 0.01 increase in the frailty index, we obtained consistent results. Conclusions The present study demonstrated that frailty was not only significantly related to an increased risk of all-cause mortality but was also a strong predictor of cause-specific mortality from CVD, cancer, and respiratory illness in community-dwelling adults. More studies are warranted to clarify the relationship between frailty and cause-specific mortality from dementia, infection, and COVID-19. Trial registration PROSPERO (CRD42021276021).

The iodine to calcium ratio in carbonate (I/Ca) has been widely used to indicate ocean oxygenation level in the past. Given the volatility of iodine, I/Ca has been measured in alkaline solutions in previous studies. However, this limits the application of I/Ca with other element/Ca (El/Ca) proxies at the same time and in the same foraminifera because other El/Ca data are preferably analyzed in acidic solutions. This study assesses the reliability of I/Ca measurements in acidic solutions measured with other El/Ca as well as the effects of different sample pre‐treatments on measured foraminiferal I/Ca. Our results show that when samples are measured within hours of prepaparation, the pH of the final solution has an insignificant effect on I/Ca measurements of a carbonate reference material JCp‐1 and a multi‐element standard solution, consistent with the slow kinetics of iodine volatilization. We find, however, that low pH possibly reduces the measured I/Ca in foraminiferal tests in some samples. Our experiments also suggest a resolvable effect of reductive cleaning, yielding lower foraminiferal I/Ca compared to without reductive cleaning. The HNO3 concentration used to dissolve foraminiferal shells has a negligible effect. Despite the different solution pHs and cleaning and dissolving methods, our core top planktic I/Ca data are able to differentiate well‐oxygenated from oxygen‐depleted waters in the upper ocean, and after correcting for cleaning effect, our data are generally consistent with the published studies that analyzed I/Ca without reductive cleaning and in basic solutions. This study shows that measurements of I/Ca within hours of sample dissolutions yield reliable planktic I/Ca data, while also allowing the acquisition of other El/Ca values for paleoceanographic studies. Plain Language Summary The ratio of chemical elements iodine to calcium (I/Ca) in carbonate has been widely used to indicate the amount of oxygen in modern and ancient oceans. Because iodine is unstable in acidic solutions, I/Ca ratios have been measured in alkaline solutions. However, acquiring I/Ca ratios in this way limits the usage of other element to calcium ratios (El/Ca) that can reflect other physical and chemical properties of the ocean such as temperature and acidity, because these El/Ca ratios are commonly measured in acidic solutions. Here we assess the possibility of producing reliable I/Ca with other El/Ca data in acidic solutions. Our results suggest that I/Ca in foraminiferal (single‐celled animal in the ocean) carbonate shells measured in acidic solutions are consistent with those published but measured in alkaline solutions. This confirms the reliability of our new analytical method, which allows measurement of other El/Ca ratios alongside I/Ca. Key Points Analysis of foraminiferal I/Ca in acidic solutions under controlled conditions offers reliable redox proxy estimates Variable sample preparations may affect I/Ca data, but the difference between oxygen‐enriched and oxygen‐depleted waters is maintained

Bamboo corals are promising archives of paleoceanographic conditions. Existing calibrations for element‐to‐calcium ratio (El/Ca) proxies of bamboo corals, however, are not necessarily calibrated to contemporaneous environmental parameters, thus weakening the reliability of the proxies. Here, we aim at calibrating the proxies by comparing El/Ca in the outermost surface of the calcareous skeletons of live‐collected bamboo corals from the South China Sea (SCS) with modern environmental records. Statistical analysis suggests that Mg/Ca and Ba/Ca can be expressed as a function of in situ seawater temperature and silicate concentration, respectively, that is, Mg/Ca (mmol/mol) = 2.17 ± 0.51 * T (°C) + 74.90 ± 2.66 and Ba/Ca (μmol/mol) = 0.070 ± 0.020 * Silicate (μmol/kg) + 7.27 ± 2.42. The slope of the Mg/Ca‐T equation from this study is slightly different from that in a previous study on bamboo corals, likely due to taxonomic and/or geographic differences of the corals and/or differences in sampling strategy and pre‐treatment method. Intra‐ and inter‐coral variations have small effects on Mg/Ca, yielding an uncertainty of 2.04 mmol/mol in Mg/Ca (95% confidence interval), equivalent to 0.94°C in estimated temperature. The slope of the Ba/Ca‐silicate equation is the same as that in a previous study, suggesting little effect of geographic difference on Ba/Ca. Intra‐ and inter‐coral variations in Ba/Ca are larger than those in Mg/Ca, possibly reflecting incorporation of multiple Ba‐rich particulate phases and/or highly variable nutrient concentrations in the micro‐environment near corals. These new calibrations allow reconstructions of paleo‐temperature and nutrient concentration in the SCS on decadal and longer timescales. Plain Language Summary Bamboo corals, a type of corals that live in the deep‐sea and whose skeletons comprise alternating inorganic and organic sections, can record ambient seawater properties while they are living, reflected by the chemical composition, specifically, the ratios of other elements to calcium (El/Ca), of their skeletons. The El/Ca values of fossil coral skeletons may in turn be used as proxies of environmental conditions in the ancient ocean. Previous studies on live corals do not necessarily compare El/Ca values with contemporaneous environmental conditions, weakening the reliability of these proxies. Here, we aim at improving the proxy calibrations by comparing El/Ca in the outermost surface of the calcareous skeletons of live‐collected bamboo corals from the South China Sea (SCS) with modern environmental records. Statistical analysis suggests that the ratio of magnesium and barium to calcium (Mg/Ca and Ba/Ca) can be expressed as a function of ambient seawater temperature and silicate concentration, respectively. These new results allow the estimation of temperature and nutrient concentration in the ancient SCS on decadal and longer timescales. Key Points Cleaning by alcohol and oxidative solution is necessary before measuring element‐to‐calcium ratios of bamboo corals Mg/Ca and Ba/Ca in bamboo corals from the South China Sea reflect ambient seawater temperature and silicate concentration, respectively

Background Cerebral ischemia-reperfusion injury (I/R) can affect patient outcomes and can even be life-threatening. This study aimed to explore the role of Shionone in cerebral I/R and reveal its mechanism of action through the cerebral I/R in vitro model. Methods SH-SY5Y cells were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) to induce cerebral I/R in vitro model. SH-SY5Y cells were treated with different concentrations of Shionone. Cell counting kit-8 and flow cytometry assays were used to detect cell viability and apoptosis levels. The levels of superoxide dismutase, catalase, and malondialdehyde were determined using their corresponding kits to examine the level of oxidative stress. The inflammation response was detected by IL-6, IL-1β, and TNF-α levels, using enzyme-linked-immunosorbent-assay. RT-qPCR was performed to measure the mRNA levels of p38 and NF-κB. Western blotting was used to quantify the apoptosis-related proteins and p38MAPK/NF-κB signaling pathway proteins. Results Shionone exhibited no toxic effects on SH-SY5Y cells. Shionone inhibited OGD/R-induced cell apoptosis, improved the inflammatory response caused by OGD/R, and reduced the level of oxidative stress in cells. Western blot assay results showed that Shionone alleviated OGD/R-induced injury by inhibiting the activity of the p38 MAPK/NF-κB signaling pathway. The p38/MAPK agonist P79350 reversed the beneficial effects of Shionone. Conclusion Shionone alleviates cerebral I/R and may thus be a novel therapeutic strategy for treating cerebral I/R.

Vertical cavity surface emitting lasers (VCSELs) have emerged as a versatile and promising platform for developing advanced integrated photonic devices and systems due to their low power consumption, high modulation bandwidth, small footprint, excellent scalability, and compatibility with monolithic integration. By combining these unique capabilities of VCSELs with the functionalities offered by micro/nano optical structures (e.g. metasurfaces), it enables various versatile energy-efficient integrated photonic devices and systems with compact size, enhanced performance, and improved reliability and functionality. This review provides a comprehensive overview of the state-of-the-art versatile integrated photonic devices/systems based on VCSELs, including photonic neural networks, vortex beam emitters, holographic devices, beam deflectors, atomic sensors, and biosensors. By leveraging the capabilities of VCSELs, these integrated photonic devices/systems open up new opportunities in various fields, including artificial intelligence, large-capacity optical communication, imaging, biosensing, and so on. Through this comprehensive review, we aim to provide a detailed understanding of the pivotal role played by VCSELs in integrated photonics and highlight their significance in advancing the field towards efficient, compact, and versatile photonic solutions.

Background To examine the progression-free survival from disease worsening after the implementation of routine screening for psychological problems in hospitalized patients with inflammatory bowel diseases (IBDs) during a long-term follow-up. Methods The retrospective cohort study enrolled 1265 patients with active IBDs. Their records were stratified into screening cohort ( n  = 827), receiving screening for psychological problems within 48 h after admission, and a 2:1 propensity score matching was utilized to match cases without screening as controls ( n  = 438). Primary endpoint was the progression-free survival from disease worsening defined as any IBDs-related emergency room visit, hospitalization or surgery during 12 months post-discharge. Secondary outcomes included quality of life (QoL) using quality-adjusted life years (QALYs) and adverse events. Results The rate of progression-free survival from IBDs worsening was observed in 73.2% of patients in screening cohort, while 53.4% of cases in control cohort (odds ratio (OR) = 2.376 (95%CI: 1.864, 3.028), p  < 0.001). Compared with controls, cases in screening cohort showed a superior mean of progression-free survival (log-rank p  < 0.001) and a greater QALYs during the 12-month follow-up ( p  < 0.001). Patients in screening cohort were more likely to have hospital-acquired venous thromboembolism and pneumonia due to a longer hospital stay. No severe adverse events were observed. Conclusions There was evidence that patients in screening cohort had a better progression-free survival from IBDs worsening than those without these conditions, and also exhibited a better QoL during 12-month follow-up. It should be encouraged that hospitalized IBDs in active phase should be routinely screened for psychological problems that could influence disease course.