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Understanding the competition between superconductivity and other ordered states (such as antiferromagnetic or charge-density-wave (CDW) state) is a central issue in condensed matter physics. The recently discovered layered kagome metal A V 3 Sb 5 ( A  = K, Rb, and Cs) provides us a new playground to study the interplay of superconductivity and CDW state by involving nontrivial topology of band structures. Here, we conduct high-pressure electrical transport and magnetic susceptibility measurements to study CsV 3 Sb 5 with the highest T c of 2.7 K in A V 3 Sb 5 family. While the CDW transition is monotonically suppressed by pressure, superconductivity is enhanced with increasing pressure up to P1 ≈ 0.7 GPa, then an unexpected suppression on superconductivity happens until pressure around 1.1 GPa, after that, T c is enhanced with increasing pressure again. The CDW is completely suppressed at a critical pressure P2 ≈ 2 GPa together with a maximum T c of about 8 K. In contrast to a common dome-like behavior, the pressure-dependent T c shows an unexpected double-peak behavior. The unusual suppression of T c at P1 is concomitant with the rapidly damping of quantum oscillations, sudden enhancement of the residual resistivity and rapid decrease of magnetoresistance. Our discoveries indicate an unusual competition between superconductivity and CDW state in pressurized kagome lattice. The recently discovered kagome metal A V 3 Sb 5 is a new playground to study the interplay between superconductivity and charge-density-wave (CDW) state. Here, the authors report pressure-dependent evolution of CDW and superconductivity in CsV 3 Sb 5 , suggesting an unusual competition between the two phases.

Inflammatory cytokines, components of cancer stem cells (CSCs) niche, could affect the characteristics of CSCs such as self-renewal and metastasis. Interleukin-17 (IL-17) is a new pro-inflammatory cytokine mainly produced by T-helper (Th17) cells and macrophages. The effects of IL-17 on the characteristics of CSCs remain to be explored. Here we first demonstrated a role of IL-17 in promoting the self-renewal of ovarian CD133 + cancer stem-like cells (CSLCs). We detected IL-17-producing cells (CD4 + cells and CD68 + macrophages) in the niche of CD133 + CSLCs. Meanwhile, there was IL-17 receptor expression on CD133 + CSLCs derived from A2780 cell line and primary ovarian cancer tissues. By recombinant human IL-17 stimulation and IL-17 transfection, the growth and sphere formation capacities of ovarian CD133 + CSLCs were significantly enhanced in a dose-dependent manner. Moreover, ovarian CD133 + CSLCs transfected with IL-17 showed greater tumorigenesis capacity in nude mice. These data suggest that IL-17 promoted the self-renewal of ovarian CD133 + CSLCs. Further investigation through gene profiling revealed that the stimulation function of IL-17 on self-renewal of ovarian CD133 + CSLCs might be mediated by the nuclear factor (NF)-κB and p38 mitogen-activated protein kinases (MAPK) signaling pathway. NF-κB and p38 MAPK were activated by IL-17. More importantly, IL-17-promoted self-renewal was inhibited by specific inhibitors of NF-κB and p38 MAPK. Taken together, our data indicate that IL-17 contributed to ovarian cancer malignancy through promoting the self-renewal of CD133 + CSLCs and that IL-17 and its signaling pathway might serve as therapeutic targets for the treatment of ovarian cancer.

High pressure electric transport and synchrotron x-ray diffraction (XRD) measurements together with the first-principles calculations are performed on a shandite compound Pd3Pb2Se2 which contains the Kagome lattice of the transition metal Pd. A pressure-induced superconducting transition is observed above 25 GPa, for the first time in the shandite compounds, although the crystal structure of the compound seems to be very robust and persists up to the highest pressure in the XRD study (76.3 GPa). The superconducting transition temperature is about 2.2 K and almost does not change with pressure. The carrier density suddenly increases around 20 GPa possibly due to the emergence of two electron pockets at the Γ point. Our work indicates that the superconductivity in Pd3Pb2Se2 is strongly correlated to its electronic structure.

is an opportunistic pathogen that causes an increasing number of serious infections. This study aimed to investigate the etiology of the severe clinical symptoms of sepsis in preterm infants and the characterization of isolates. Whole-genome sequencing (WGS) was performed on three strains isolated from an infected preterm infant. Additionally, the genomic sequences of 534 strains were obtained from the NCBI database. To gain deeper insights into these strains, we utilized the Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Clusters of Orthologous Groups (COG), and Pathogen Host Interactions (PHI) database annotation tools for comprehensive gene function analyses. Moreover, the multilocus sequence typing (MLST), EasyCGtree, and virulence factor database (VFDB) were employed to determine the sequence types (STs), construct phylogenetic trees, and identify potential virulence factors. Sequence analysis found that the three isolated strains had identical sequence characteristics and did not correspond to any of the known ST types. Virulence factor analysis revealed that the three strains harbored , and capsule genes. These virulence factors are likely to play crucial roles in enhancing adhesion and metabolic capabilities, resisting phagocytosis (inducing immune cell damage), and ultimately contributing to prolonged bacteremia. The phylogenetic tree and comparative genomics of virulence factors showed the genetic and virulence factor diversity of the currently reported strains. We identified a novel strain of that exhibits high virulence and leads to severe septicemia phenotypes in preterm infants. Furthermore, comparative genomic analysis of previously reported strains revealed the existence of three clades. This comprehensive analysis provides novel insights into the genetic relationships and virulence factor profiles of diverse strains of . In future, it will be necessary to investigate the concept of the high virulence of to determine the treatment method.

The objective of this work is to investigate the effect of the bionic microstructure surface on flow field structure of the slab. The motivation behind this study is to investigate the effect of the bionic microstructure parameters including the height and intersection angle of microstructure in order to improve the drag reduction characters. The numerical simulation is performed on the bionic microstructure model of the V-shaped and serrated bionic microstructures using the RNG k-ε model. The drag reduction rates of two bionic microstructures under different dimensionless sizes are ob13.79 tained. The drag reduction efficiency is up to 8.76% when the dimensionless height of microstructure is at and the intersection angle for V-shaped microstructure. In addition, combined with wall temperature control of drag reduction technology, the influence of wall temperature on the drag reduction effect is also analyzed. Compared with the flow field structure of the surface boundary layer of the smooth plate, the wall microstructure divides the surface boundary layer into two parts: the bottom and the tip. The average velocity profile is moved up and the thickness of the linear bottom layer is increased. A large number of \"quiet\" fluids are gathered at the bottom of the surface boundary layer. In addition, the existence of wall microstructure can weaken the momentum exchange in the boundary layer and restrain the spreading vortex motion of the fluid in the near-wall region. The \"secondary vortex pair\" on both sides of the tip of the microstructures can effectively limit the lateral pulsation of fluid So as to achieve a good drag reduction effect‎.

Aim: Thalassaemia is a good candidate disease for control by preventive genetic programmes in developing countries. Accurate population frequency data are needed for planning the control of thalassaemia in the high risk Guangdong Province of southern China. Methods: In total, 13 397 consecutive samples from five geographical areas of Guangdong Province were analysed for both haematological and molecular parameters. Results: There was a high prevalence of carriers of α thalassaemia (8.53%), β thalassaemia (2.54%), and both α and β thalassaemia (0.26%). Overall, 11.07% of the population in this area were heterozygous carriers of α and β thalassaemia. The mutation spectrum of α and β thalassaemia and its constitution were fully described in this area. This study reports the true prevalence of silent α thalassaemia in the southern China population for the first time. In addition, two novel mutations that give rise to α thalassaemia, one deletion resulting in β thalassaemia, and a rare deletion (−−THAI allele) previously unreported in mainland China were detected. The frequency of the most common mutation, the Southeast Asian type of deletion (−−SEA, accounting for 48.54% of all α thalassaemias) was similar to the total of two α+ thalassaemia deletions (−α3.7 and −α4.2, accounting for 47.49% of α thalassaemia). Conclusion: Both α and β thalassaemia are widely distributed in Guangdong Province of China. The knowledge gained in this study will enable the projected number of pregnancies at risk to be estimated and a screening strategy for control of thalassaemia to be designed in this area.

The radioactive decay of radon and its progeny can lead to ionization of air molecules and consequently influence aerosol size distribution. In order to provide a global estimate of the radon-related ionization rate, we use the global atmospheric model ECHAM5 to simulate transport and decay processes of the radioactive tracers. A global radon emission map is put together using regional fluxes reported recently in the literature. Near-surface radon concentrations simulated with this new map compare well with measurements. Radon-related ionization rate is calculated and compared to that caused by cosmic rays. The contribution of radon and its progeny clearly exceeds that of the cosmic rays in the mid- and low-latitude land areas in the surface layer. During cold seasons, at locations where high concentration of sulfuric acid gas and low temperature provide potentially favorable conditions for nucleation, the coexistence of high ionization rate may help enhance the particle formation processes. This suggests that it is probably worth investigating the impact of radon-induced ionization on aerosol-climate interaction in global models.

The National Geomatics Atlas is the first volume of the new century edition of the National Huge Atlas of the People's Republic of China, and is one of the important achievements of this research and development project. The National Geomatics Atlas consists of four thematic map groups and one place name index, such as the sequence map group, the political terrain map group, the land cover map group and the city map group. The research object of this paper is the thematic maps, which are mainly distributed in the sequence map group, the land cover map group and the city map group. This paper is aimed at the design and compilation of thematic maps, including a brief introduction of thematic maps selection, layout design, thematic map technical process, and thematic symbol design.

Ras-Association Domain Family 10 (RASSF10) is the last identified member of the RASSF family. The functional characteristics of this new gene in human cancers remain largely unclear. Here, we examined RASSF10 for the biological functions and related molecular mechanisms in hepatocellular carcinoma (HCC). We found that RASSF10 is expressed in normal human liver tissue, but is silenced or down-regulated in 62.5% (5/8) of HCC cell lines. The mean expression level of RASSF10 was significantly lower in primary HCCs compared with their adjacent normal tissues ( P <0.005, n =52). The promoter methylation contributes to the inactivation of RASSF10 as demonstrated by bisulfite genomic sequencing and demethylation treatment analyses. Transgenic expression of RASSF10 in silenced HCC cell lines suppressed cell viability, colony formation and inhibited tumor growth in nude mice (QGY7703, P <0.01; HepG2, P <0.05). Furthermore, RASSF10 was shown to induce the cell accumulation in G1 phase with the increase of p27, as well as the decrease of cyclinD1 and CDK2/CDK4. Over-expression of RASSF10 also inhibited HCC cells migration ( P <0.01) or invasion ( P <0.05). Adhesion genes array revealed that Matrix Metalloproteinase 2 (MMP2) was a downstream effector of RASSF10. RASSF10 acting as a tumor suppressor to inhibit HCC invasion partially mediated by Focal Adhesion Kinase or p38 MAPK to decrease the accumulation of MMP2. Our study suggests that RASSF10 acts as a tumor suppressor for HCC.