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Unmanned aerial vehicle (UAV) remote sensing technology can be used for fast and efficient monitoring of plant diseases and pests, but these techniques are qualitative expressions of plant diseases. However, the yellow leaf disease of arecanut in Hainan Province is similar to a plague, with an incidence rate of up to 90% in severely affected areas, and a qualitative expression is not conducive to the assessment of its severity and yield. Additionally, there exists a clear correlation between the damage caused by plant diseases and pests and the change in the living vegetation volume (LVV). However, the correlation between the severity of the yellow leaf disease of arecanut and LVV must be demonstrated through research. Therefore, this study aims to apply the multispectral data obtained by the UAV along with the high-resolution UAV remote sensing images to obtain five vegetation indexes such as the normalized difference vegetation index (NDVI), optimized soil adjusted vegetation index (OSAVI), leaf chlorophyll index (LCI), green normalized difference vegetation index (GNDVI), and normalized difference red edge (NDRE) index, and establish five algorithm models such as the back-propagation neural network (BPNN), decision tree, naïve Bayes, support vector machine (SVM), and k-nearest-neighbor classification to determine the severity of the yellow leaf disease of arecanut, which is expressed by the proportion of the yellowing area of a single areca crown (in percentage). The traditional qualitative expression of this disease is transformed into the quantitative expression of the yellow leaf disease of arecanut per plant. The results demonstrate that the classification accuracy of the test set of the BPNN algorithm and SVM algorithm is the highest, at 86.57% and 86.30%, respectively. Additionally, the UAV structure from motion technology is used to measure the LVV of a single areca tree and establish a model of the correlation between the LVV and the severity of the yellow leaf disease of arecanut. The results show that the relative root mean square error is between 34.763% and 39.324%. This study presents the novel quantitative expression of the severity of the yellow leaf disease of arecanut, along with the correlation between the LVV of areca and the severity of the yellow leaf disease of arecanut. Significant development is expected in the degree of integration of multispectral software and hardware, observation accuracy, and ease of use of UAVs owing to the rapid progress of spectral sensing technology and the image processing and analysis algorithms.

The number of rubber plantations has increased significantly since 2000, especially in Southeast Asia and China, and their ecological impacts are becoming more evident. A robust rubber supply monitoring system is currently required at both the production and ecological levels. This study used Sentinel-2 multi-rule remote sensing images and a deep learning method to construct a deep learning model that could generate a distribution map of rubber plantations in Danzhou City, Hainan Province, from 2019 to 2024. For biomass modeling, 52 sample plots (27 of which were historical plots) were integrated, and the canopy structure was extracted as an auxiliary variable from the point cloud data generated by an unmanned aerial vehicle survey. Five algorithms, namely Random Forest (RF), Gradient Boosting Decision Tree, Convolutional Neural Network, Back Propagation Neural Network, and Extreme Gradient Boosting, were used to characterize the spatiotemporal changes in rubber plantation biomass and analyze the driving mechanisms. The developed deep learning model was exceptional at identifying rubber plantations (overall accuracy = 91.63%, Kappa = 0.83). The RF model performed the best in terms of biomass prediction (R2 = 0.72, RRMSE = 21.48 Mg/ha). Research shows that canopy height as a characteristic factor enhances the explanatory power and stability of the biomass model. However, due to limitations such as sample plot size, image differences, canopy closure degree, and point cloud density, uncertainties in its generalization across years and regions remain. In summary, the proposed framework effectively captures the spatial and temporal dynamics of rubber plantations and estimates their biomass with high accuracy. This study provides a crucial reference for the refined management and ongoing monitoring of rubber plantations.

Biomass carbon sequestration and sink capacities of tropical rainforests are vital for addressing climate change. However, canopy height must be accurately estimated to determine carbon sink potential and implement effective forest management. Four advanced machine-learning algorithms—random forest (RF), gradient boosting decision tree, convolutional neural network, and backpropagation neural network—were compared in terms of forest canopy height in the Hainan Tropical Rainforest National Park. A total of 140 field survey plots and 315 unmanned aerial vehicle photogrammetry plots, along with multi-modal remote sensing datasets (including GEDI and ICESat-2 satellite-carried LiDAR data, Landsat images, and environmental information) were used to validate forest canopy height from 2003 to 2023. The results showed that RH80 was the optimal choice for the prediction model regarding percentile selection, and the RF algorithm exhibited the optimal performance in terms of accuracy and stability, with R2 values of 0.71 and 0.60 for the training and testing sets, respectively, and a relative root mean square error of 21.36%. The RH80 percentile model using the RF algorithm was employed to estimate the forest canopy height distribution in the Hainan Tropical Rainforest National Park from 2003 to 2023, and the canopy heights of five forest types (tropical lowland rainforests, tropical montane cloud forests, tropical seasonal rainforests, tropical montane rainforests, and tropical coniferous forests) were calculated. The study found that from 2003 to 2023, the canopy height in the Hainan Tropical Rainforest National Park showed an overall increasing trend, ranging from 2.95 to 22.02 m. The tropical montane cloud forest had the highest average canopy height, while the tropical seasonal forest exhibited the fastest growth. The findings provide valuable insights for a deeper understanding of the growth dynamics of tropical rainforests.

PARP inhibitors and HDAC inhibitors have been approved for the clinical treatment of malignancies, but acquired resistance of or limited effects on solid tumors with a single agent remain as challenges. Bioinformatics analyses and a combination of experiments had demonstrated the synergistic effects of PARP and HDAC inhibitors in triple-negative breast cancer. A series of novel dual PARP and HDAC inhibitors were rationally designed and synthesized, and these molecules exhibited high enzyme inhibition activity with excellent antitumor effects in vitro and in vivo. Mechanistically, dual PARP and HDAC inhibitors induced BRCAness to restore synthetic lethality and promoted cytosolic DNA accumulation, which further activates the cGAS–STING pathway and produces proinflammatory chemokines through type I IFN-mediated JAK–STAT pathway. Moreover, these inhibitors promoted neoantigen generation, upregulated antigen presentation genes and PD-L1, and enhanced antitumor immunity when combined with immune checkpoint blockade therapy. These results indicated that novel dual PARP and HDAC inhibitors have antitumor immunomodulatory functions in triple-negative breast cancer. Novel dual PARP and HDAC inhibitors induce BRCAness to restore synthetic lethality, activating tumoral IFN signaling via the cGAS–STING pathway and inducing cytokine production, promoting neoantigen generation and presentation to enhance the immune response.

Soil erosion by water is a major cause of land degradation. Agricultural practices and many other ecological environmental problems contribute to land degradation worldwide, especially in arid and semi-arid areas. Miyun County, which is located in a mountainous region of North China, is an important natural ecological zone and surface source of drinking water for Beijing and is very vulnerable to soil erosion due to its thin soil layer and human activities. Landsat images from 2003 and 2013 were used to analyze the land-use and land-cover change (LULCC) over this period. The revised universal soil loss equation (RUSLE) model integrated with Geographic Information System (GIS) was used to quantify soil loss and to map erosion risk. In addition, the response of soil erosion to LULCC was evaluated. The results showed that the areas under cropland, forest, and water bodies increased over the study period by 66.03, 243.44, and 9.01 km2, respectively. The increase in forested land indicated that the improved ground vegetation cover was due to the implementation of active ecological measures. Between 2003 and 2013, light soil erosion increased by 587.46 km2, and extremely severe soil erosion increased by 9.57 km2. The extents of slight, moderate, severe, and very severe soil erosion, however, decreased by 8.02, 445.21, 142.69, and 1.11 km2, respectively. A total of 57.5% of land with moderate soil erosion has been converted to light soil erosion, which could be highly beneficial for the improvement of vegetation control of soil and water losses. In terms of area, forestland exhibited the greatest increase, while moderate soil erosion exhibited the greatest decrease over the study period. Land-use change led to an alteration in the intensity of soil erosion due to changes or loss of vegetation. The conversion from high intensity soil erosion to low intensity was attributed to the implementation of ecological environmental protection. The results generated from this study may be useful for planners and land-use managers to make appropriate decisions for soil conservation.

Mangrove ecosystems play a dominant role in global, tropical, and subtropical coastal wetlands. Remote sensing plays a central role in mangrove conservation, as it is the preferred tool for monitoring changes in spatiotemporal distribution. To improve correlated estimation accuracies and explore the influencing mechanisms based on the mangrove ground survey, this study used a support vector machine (SVM) machine learning and Res-UNet deep learning algorithms to identify the land area of mangrove forests and the crown surface cover area of mangrove forests in the Hainan Island from 1991 to 2021. Both classification techniques were verified by a confusion matrix, which from 1991 to 2021, revealed overall accuracies of 93.11 ± 1.54% and 96.43 ± 1.15% for SVM and Res-UNet, respectively. Res-UNet was more accurate in identifying the crown surface cover area, whereas SVM was more suitable for obtaining the land area. Furthermore, based on the crown surface cover area of the mangrove forests on the Hainan Island, influencing mechanisms were analyzed through dynamic changes and landscape patterns. Since 1991, the Hainan Island mangrove forest area has increased, with the center of mass moving from coastal areas to the ocean and increasing the overall landscape fragmentation. Moreover, the change in the mangrove forests area was correlated with economic development and the increasingly urban population of the entire island. Altogether, the reliable assessment of the tropical mangrove forest land area and crown surface cover provides an important research foundation for the protection and restoration plans of tropical mangrove forests.

As an essential blue carbon ecosystem, mangroves play a vital role in coastal protection, biodiversity conservation, and climate regulation. However, their complex and variable growth environments pose challenges for precise monitoring. Hainan Island represents a region within China where mangrove forests are the most concentrated and diverse in type. In recent years, ecological restoration efforts have led to the recovery of their coverage areas. This study analyzed the spatial distribution, canopy height, and aboveground carbon storage variations in Hainan mangrove forests. Deep-learning and multiple machine-learning algorithms were used to integrate multitemporal Sentinel-2 remote sensing imagery from 2019 to 2023 with unmanned aerial vehicle observations and field survey data. Multi-rule image fusion and deep-learning techniques effectively enhanced mangrove identification accuracy. The mangrove classification achieved an overall accuracy exceeding 90%. The mangrove area in Hainan increased from 3948.83 ha in 2019 to 4304.29 ha in 2023. Gradient-boosted decision tree (GBDT) models estimated average canopy height with a high coefficient of determination (R2 = 0.89), and Random Forest (RF) models yielded the best estimations of total above-ground carbon stock with strong agreement to field observations. Integrating multisource remote sensing data with artificial intelligence algorithms enabled high-precision dynamic monitoring of mangrove distribution, structure, and carbon storage to provide scientific support for the assessment, management, and carbon sink accounting of Hainan mangrove ecosystems.

Tropical rainforests play a vital role in maintaining global ecological balance, carbon cycling, and biodiversity conservation, making research on their biomass dynamics scientifically significant. This study integrates multi-source remote sensing data, including canopy height derived from GEDI and ICESat-2 satellite-borne lidar, Landsat imagery, and environmental variables, to estimate forest biomass dynamics in Hainan’s tropical rainforests at a 30 m spatial resolution, involving a correlation analysis of factors influencing spatiotemporal changes in Hainan Tropical Rainforest biomass. The research aims to investigate the spatiotemporal variations in forest biomass and identify key environmental drivers influencing biomass accumulation. Four machine learning algorithms—Backpropagation Neural Network (BP), Convolutional Neural Network (CNN), Random Forest (RF), and Gradient Boosting Decision Tree (GBDT)—were applied to estimate biomass across five forest types from 2003 to 2023. Results indicate the Random Forest model achieved the highest accuracy (R2 = 0.82). Forest biomass and carbon stocks in Hainan Tropical Rainforest National Park increased significantly, with total carbon stocks rising from 29.03 million tons of carbon to 42.47 million tons of carbon—a 46.36% increase over 20 years. These findings demonstrate that integrating multimodal remote sensing data with advanced machine learning provides an effective approach for accurately assessing biomass dynamics, supporting forest management and carbon sink evaluations in tropical rainforest ecosystems.

The tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases (TFKs) are a subfamily of non-receptor protein tyrosine kinases (PTKs) that include five members: TEC, bruton’s tyrosine kinase (BTK), interleukin 2-inducible T-cell kinase (ITK/EMT/TSK), bone marrow tyrosine kinase on chromosome X (BMX/ETK), and tyrosine-protein kinase (TXK/RLK). They play key roles in cell signaling and immune regulation. Emerging evidence highlights their involvement in cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), atherosclerosis (AS), sepsis-related dysfunction, atrial fibrillation (AF), myocardial hypertrophy, coronary atherosclerotic heart disease, myocardial infarction (MI), and post-myocardial infarction complications. However, no review has comprehensively addressed the cardiovascular toxicity of TFKs inhibitors. This review provides a comprehensive and systematic analysis of the cardiovascular toxicity profiles of TFK inhibitors (TFKis), focusing on underlying molecular mechanisms, comparing toxicity across different agents and generations, and discussing clinical implications.

Tropical forests, although covering only 7% of the world’s land area, have great forest carbon sequestration capacity, accounting for 20% of the world’s forest carbon sink. However, the growth dynamics and forest carbon sink potential of tropical forests remain unclear. Hainan Island is going to be China’s forest carbon trading center. Therefore, accurately assessing the future forest carbon sink potential of Hainan Island’s tropical forest is crucial. In this study, 393 forest permanent sample plots in Hainan Island in 2003, 2008, 2013, and 2018 were selected as the research objects. The dynamic model of tropical forest growth with the geospatial environmental indicators was established based on the measured and most accurate annual diameter at breast height (DBH) growth factors. The DBH growth prediction’s bias ranged from 0.46 to 0.07 cm, RMSE ranged from 1.50 to 5.29 cm, bias% ranged from -2.96 to 0.55%, and RRMSE ranged from 12.18 to 34.30%. In addition, the geospatial environmental indicators of forest growth provide scientific guidance for future ecological protection and land evolution of Hainan Island. Based on DBH–tree height–volume, volume–biomass, and biomass–forest carbon storage relationships, forest carbon sequestration potential could be accurately evaluated by DBH growth. The results show that within the next 30 years, the forest carbon sequestration in Hainan Island will account for 1.8% of the total forest carbon sequestration in China, while the forest area will only account for 0.88% of the total forest area in China. It is roughly estimated that in the next 30 years, the total carbon sink of the tropical forest in Hainan Island will be 83.59 TgC. This study further proves that the annual increase in DBH can accurately assess the forest carbon sink potential of the forest. The forest carbon sink prediction based on the annual increase in DBH can provide data support and theoretical basis for forest carbon sink trading between forest farms and enterprises.