Explore the vast range of titles available.

Approximately 1 in 10 patients undergoing surgery is considered at high risk for poor pain and opioid-related outcomes due to chronic pain or persistent opioid use prior to surgery, leading to increased hospital lengths of stay, emergency department visits, hospital readmissions, and worse long-term outcomes. Multidisciplinary transitional pain services (TPSs) have been shown to effectively identify and optimize high-risk patients before surgery, leading to a reduction in healthcare utilization. We conducted a series of semistructured interviews, a literature search, and a financial analysis to develop a reproducible business case for establishing a TPS. These interviews involved discussions with clinicians and administrators at Michigan Medicine, as well as leaders of TPS initiatives at peer institutions across the USA and Canada. The aim was to understand possible operational structures and potential sources of revenue and cost savings that needed inclusion in our model. Subsequently, the authors developed a modifiable financial modeling tool, which is freely available for download and adaptable to any healthcare institution. The model suggests that the primary source of cost savings can be attributed to a reduction in length of stay. Furthermore, several operational options exist for incorporating a TPS that performs at breakeven or positive net profit. This tool and these findings are important for informing health systems of operational and financial considerations when implementing a TPS program. Future research should evaluate this financial tool’s reproducibility in community health system contexts.

Chronic pain research studies are important for both finding new treatments and improving existing treatments for individuals with chronic pain. For clinical trials to be effective, participants need to be engaged and willing to participate in treatment groups. Our research applies the theory of planned behavior (TPB) to understand how attitudes, perceived social norms, and perceived control over intervention engagement are associated with willingness to participate in interventions for chronic low back pain (CLBP). Adult Michigan Medicine patients were identified using electronic medical records and emailed a link to an online, cross-sectional survey. Participants who self-reported CLBP, ability to read and write in English, and consented to participate were able to complete the survey ( = 405). The results showed more positive attitudes, positive social norms, and higher perceived behavioral control related to specific chronic low back pain interventions are associated with greater willingness to participate after controlling for demographic and pain-related characteristics. The findings suggest that TPB constructs may be useful in guiding recruitment efforts for chronic pain intervention trials.

Research experience is often important for academic and career development. This paper describes the implementation and impact of a training program for temporary research assistants (RAs) at an academic medical center. The program includes a 9-month didactic lecture series covering research and professional development skills, a Quality Improvement project focused on improving research processes, and manuscript writing. Overall, the program goals of increasing confidence, self-efficacy, job satisfaction, and well-being, as well as providing an opportunity for career exploration, were met. Thus, this program has the potential to support temporary RAs and enhance their early research experiences.

Purpose of Review A wellspring of new research has offered varying models of resilience in chronic pain populations; however, resilience is a multifaceted and occasionally nebulous construct. The current review explores definitional and methodological issues in existing observational and clinical studies and offers new directions for future studies of pain resilience. Recent Findings Definitions of pain resilience have historically relied heavily upon self-report and from relatively narrow scientific domains (e.g., positive psychology) and in narrow demographic groups (i.e., Caucasian, affluent, or highly educated adults). Meta-analytic and systematic reviews have noted moderate overall quality of resilience-focused assessment and treatment in chronic pain, which may be attributable to these narrow definitions. Summary Integration of research from affiliated fields (developmental models, neuroimaging, research on historically underrepresented groups, trauma psychology) has the potential to enrich current models of pain resilience and ultimately improve the empirical and clinical utility of resilience models in chronic pain.

Mental healthcare is largely unavailable throughout Haiti, particularly in rural areas. The aim of the current study is to explore perceived feasibility, acceptability, and effectiveness of potential culturally adapted interventions to improve mental health among Haitian women. The study used focus group discussions (n = 12) to explore five potential interventions to promote mental health: individual counseling, income-generating skills training, peer support groups, reproductive health education, and couples’ communication training. Findings indicate that individual counseling, support group, and skills training components were generally anticipated to be effective, acceptable, and feasible by both male and female participants. That being said, participants expressed doubts regarding the acceptability of the couples’ communication training and reproductive health education due to: a perceived lack of male interest, traditional male and female gender roles, lack of female autonomy, and misconceptions about family planning. Additionally, the feasibility, effectiveness, and acceptability of the components were described as dependent on cost, proximity to participants, and inclusion of a female health promoter that is known in the community. Given the lack of research on intervention approaches in Haiti, particularly those targeting mental health, this study provides a foundation for developing prevention and treatment approaches for mental distress among Haitian women.

The purpose of this project report was to highlight and review the deficiencies in ethics training in academia and, subsequently, the workplace. After review of the scholarly literature, examination of the Technical and Professional Writing certificate program at California State University, Long Beach, and my experience as a graduate student and professional communication practitioner, I conclude that a solid foundation in ethics should be established, instructed, and practiced in the area of professional communication.

Background In animals, pioneer transcription factors (TFs) have long been known to be crucial molecular players in programming cell fate. However, in plants much less is known about this functional class of TFs and how they mechanistically alter local chromatin architecture in order to reprogramme gene regulation to orchestrate cell fate changes. Results Here, we provide evidence that APETALA1 (AP1) functions as a pioneer TF in Arabidopsis thaliana , facilitated by tetramerisation. Using an integrated combination of multi-omics and high-resolution imaging approaches on both wild-type and AP1 mutant transgenic plants, we show that tetramerisation assists AP1 in providing access to, and enhancing the binding of AP1 to, closed chromatin in vivo . This, in turn, allows for a switching of the chromatin state from closed to open to ensure access to target DNA sequences needed for organ specification. Conclusions These novel insights provide a mechanistic basis for how AP1 functions as a pioneer factor to reprogramme stem cells towards a “floral ground state”, increasing our understanding of how MADS-domain TFs function as combinatorial units during early Arabidopsis thaliana reproductive development.