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As interest in Moon exploration grows, and efforts to establish an orbiting outpost intensify, accurate modeling of spacecraft dynamics in cislunar space is becoming increasingly important. Contrary to satellites in Low Earth Orbit (LEO), where it takes around 5 ms to communicate back and forth with a ground station, it can take up to 2.4 s to communicate with satellites near the Moon. This delay in communication can make the difference between a successful docking and a catastrophic collision for a remotely controlled satellite. Moreover, due to the unstable nature of trajectories in cislunar space, it is necessary to design spacecraft that can autonomously make frequent maneuvers to stay on track with a reference orbit. The communication delay and unstable trajectories are exactly why autonomous navigation is critical for proximity operations and rendezvous and docking missions in cislunar space. Because spacecraft computational hardware is limited, reducing the computational complexity of navigational algorithms is both desirable and often necessary. By the introduction of a linear system approach to the deputy spacecraft motion, this research avoids the computational burden of integrating the deputy relative equations of motion. In this research, the relative CR3BP equations of motion are derived and linearized using a matrix exponential approximation. This research continues the development of the matrix exponential linearized relative circular restricted three-body problem (CR3BP) equations by applying the dynamics model to estimation and control applications. A simulation is performed to compare state estimation results obtained from using the linearized equations of motion utilizing a Kalman filter and for state estimation utilizing an unscented Kalman filter with the full nonlinear equations of motion. The linearized exponential model is shown to be sufficient for state estimation in the presence of noisy measurements for an example scenario. Additionally, a linear quadratic regulator (LQR) controller was added to optimally control a deputy spacecraft to rendezvous with a chief spacecraft in cislunar space. The contribution of this work is twofold: to provide a proof of concept that the matrix exponential solution for the linearized relative CR3BP equations can be used as the dynamics model for state estimation, as well as to simulate an optimal rendezvous maneuver in the presence of measurement noise.

Purpose To compare repaired cartilage with native cartilage, and inter-observer reliability, using T2 mapping at 3 T for assessing cartilage repair in osteochondral defects of the talus after the microfracture technique. Methods We enrolled eight females and seven males undergoing arthroscopic microfracture for osteochondral defects of the talus at an average follow-up of 7.9 ± 2.2 years (range 5–13 years). Cartilage tissue was assessed using a 3-T magnetic resonance imaging unit with an 8-channel phased array foot and ankle coil (gradient strength, 50 mT/m; slew rate, 200 T/m/s). T2 maps were then calculated. Three independent boarded specialists evaluated the images, and magnetic resonance observation of cartilage repair tissue scores was used to assess the cartilage and joint status. Clinical results were assessed using the Hannover Scoring System (HSS) for the ankle and the American Orthopaedic Foot and Ankle Society (AOFAS) hind-foot score. Results No significant mean differences were found between the T2 properties of the repair tissue and those of the native reference cartilage (T2 = 38.6 ± 5.3 ms, range 30.2–55.8 ms vs. 40.3 ± 8.5 ms, range 31.4–59.8 ms, respectively; intra-class correlation coefficient = 0.94; confidence interval 0.84–0.99, P  ≤ 0.001). Despite ≥50 % defect filling in all patients, subchondral bone changes were considerable. The HSS at the follow-up revealed a mean score of 87 ± 12 (range 51–97), and the AOFAS-Score was 90 ± 13 (range 59–100). Conclusions 3 T T2 maps were similar in repaired and native cartilage with good inter-observer reliability. Level of evidence IV.

A method of near real-time detection and tracking of resident space objects (RSOs) using a convolutional neural network (CNN) and linear quadratic estimator (LQE) is proposed. Advances in machine learning architecture allow the use of low-power/cost embedded devices to perform complex classification tasks. In order to reduce the costs of tracking systems, a low-cost embedded device will be used to run a CNN detection model for RSOs in unresolved images captured by a gray-scale camera and small telescope. Detection results computed in near real-time are then passed to an LQE to compute tracking updates for the telescope mount, resulting in a fully autonomous method of optical RSO detection and tracking. Keywords: Space Domain Awareness, Neural Networks, Real-Time, Object Detection, Embedded Systems.

In this paper, an autonomous method of satellite detection and tracking in images is implemented using optical flow. Optical flow is used to estimate the image velocities of detected objects in a series of space images. Given that most objects in an image will be stars, the overall image velocity from star motion is used to estimate the image's frame-to-frame motion. Objects seen to be moving with velocity profiles distinct from the overall image velocity are then classified as potential resident space objects. The detection algorithm is exercised using both simulated star images and ground-based imagery of satellites. Finally, this algorithm will be tested and compared using a commercial and an open-source software approach to provide the reader with two different options based on their need.

This work utilizes a MobileNetV2 Convolutional Neural Network (CNN) for fast, mobile detection of satellites, and rejection of stars, in cluttered unresolved space imagery. First, a custom database is created using imagery from a synthetic satellite image program and labeled with bounding boxes over satellites for \"satellite-positive\" images. The CNN is then trained on this database and the inference is validated by checking the accuracy of the model on an external dataset constructed of real telescope imagery. In doing so, the trained CNN provides a method of rapid satellite identification for subsequent utilization in ground-based orbit estimation.

This work utilizes a particle swarm optimizer (PSO) for initial orbit determination for a chief and deputy scenario in the circular restricted three-body problem (CR3BP). The PSO is used to minimize the difference between actual and estimated observations and knowledge of the chief's position with known CR3BP dynamics to determine the deputy's initial state. Convergence is achieved through limiting particle starting positions to feasible positions based on the known chief position, and sensor constraints. Parallel and GPU processing methods are used to improve computation time and provide an accurate initial state estimate for a variety of cislunar orbit geometries.

Purpose Glioblastomas (GBM) with subventricular zone (SVZ) contact have previously been associated with a specific epigenetic fingerprint. We aim to validate a reported bulk methylation signature to determine SVZ contact. Methods Methylation array analysis was performed on IDHwt GBM patients treated at our institution. The v11b4 classifier was used to ensure the inclusion of only receptor tyrosine kinase (RTK) I, II, and mesenchymal (MES) subtypes. Methylation-based assignment (SVZM ±) was performed using hierarchical cluster analysis. Magnetic resonance imaging (MRI) (T1ce) was independently reviewed for SVZ contact by three experienced readers. Results Sixty-five of 70 samples were classified as RTK I, II, and MES. Full T1ce MRI-based rater consensus was observed in 54 cases, which were retained for further analysis. Epigenetic SVZM classification and SVZ were strongly associated (OR: 15.0, p  = 0.003). Thirteen of fourteen differential CpGs were located in the previously described differentially methylated LRBA/MAB21L2 locus. SVZ + tumors were linked to shorter OS (hazard ratio (HR): 3.80, p  = 0.02) than SVZM + at earlier time points (time-dependency of SVZM, p  < 0.05). Considering the SVZ consensus as the ground truth, SVZM classification yields a sensitivity of 96.6%, specificity of 36.0%, positive predictive value (PPV) of 63.6%, and negative predictive value (NPV) of 90.0%. Conclusion Herein, we validated the specific epigenetic signature in GBM in the vicinity of the SVZ and highlighted the importance of methylation of a part of the LRBA/MAB21L2 gene locus. Whether SVZM can replace MRI-based SVZ assignment as a prognostic and diagnostic tool will require prospective studies of large, homogeneous cohorts.

The global burden of paediatric and congenital heart disease (PCHD) is substantial. We propose a novel public health framework with recommendations for developing effective and safe PCHD services in low-income and middle-income countries (LMICs). This framework was created by the Global Initiative for Children’s Surgery Cardiac Surgery working group in collaboration with a group of international rexperts in providing paediatric and congenital cardiac care to patients with CHD and rheumatic heart disease (RHD) in LMICs. Effective and safe PCHD care is inaccessible to many, and there is no consensus on the best approaches to provide meaningful access in resource-limited settings, where it is often needed the most. Considering the high inequity in access to care for CHD and RHD, we aimed to create an actionable framework for health practitioners, policy makers and patients that supports treatment and prevention. It was formulated based on rigorous evaluation of available guidelines and standards of care and builds on a consensus process about the competencies needed at each step of the care continuum. We recommend a tier-based framework for PCHD care integrated within existing health systems. Each level of care is expected to meet minimum benchmarks and ensure high-quality and family centred care. We propose that cardiac surgery capabilities should only be developed at the more advanced levels on hospitals that have an established foundation of cardiology and cardiac surgery services, including screening, diagnostics, inpatient and outpatient care, postoperative care and cardiac catheterisation. This approach requires a quality control system and close collaboration between the different levels of care to facilitate the journey and care of every child with heart disease. This effort was designed to guide readers and leaders in taking action, strengthening capacity, evaluating impact, advancing policy and engaging in partnerships to guide facilities providing PCHD care in LMICs.

Background Rheumatic heart disease (RHD) is the principal cause of acquired heart disease affecting people living largely in poverty and deprived conditions. Sub-Saharan Africa was long thought to be the hotspot of the disease but recent reports suggest that this is no longer the case. South Africa is the leading economic force within this region yet contends with continued extreme income disparities. It is of interest to ascertain whether the strides that have been made in healthcare since the democratic transition in South Africa have translated into decreased RHD burden. We therefore propose to review the current best estimates of incidence of newly diagnosed RHD and prevalence of existing RHD within the past two decades. We also propose to characterise the fatal and non-fatal outcomes of RHD and identify any trends in this period. Methods and design We plan to search electronic databases and reference lists of relevant articles published from April 1994 to April 2014. Studies will be included if they estimated one of the following epidemiological measures: incidence, prevalence, remission rate, relative risk of mortality or cause-specific mortality. For studies deemed eligible for inclusion, we will assess overall study quality, reliability and risk of bias using design-specific criteria. We will extract data using a standardised form and perform descriptive and quantitative analysis to assess RHD prevalence, mortality and morbidity. This review protocol is registered in the PROSPERO International Prospective Register of systematic reviews, registration number CRD42014007072. Dissemination Our planned review will provide healthcare providers, public health officials and policymakers with pooled contemporary data regarding RHD, in particular regarding the effect the new political dispensation has had on the burden of this preventable disease within South Africa. In addition, these important country-specific data could influence policy decisions regarding prevention, management and control of RHD.