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"de Angelis, Francesco"
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Combination of scanning probe technology with photonic nanojets
Light focusing through a microbead leads to the formation of a photonic nanojet functional for enhancing the spatial resolution of traditional optical systems. Despite numerous works that prove this phenomenon, a method to appropriately translate the nanojet on top of a region of interest is still missing. Here, by using advanced 3D fabrication techniques we integrated a microbead on an AFM cantilever thus realizing a system to efficiently position nanojets. This fabrication approach is robust and can be exploited in a myriad of applications, ranging from microscopy to Raman spectroscopy. We demonstrate the potential of portable nanojets by imaging different sub-wavelength structures. Thanks to the achieved portability, we were able to perform a detailed optical characterization of the resolution enhancement induced by the microbead, which sheds light into the many contradictory resolution claims present in literature. Our conclusions are strongly supported by rigorous data analysis and by numerical simulations, all in perfect agreement with experimental results.
Journal Article
Nanoscale chemical mapping using three-dimensional adiabatic compression of surface plasmon polaritons
The fields of plasmonics, Raman spectroscopy and atomic force microscopy have recently undergone considerable development, but independently of one another. By combining these techniques, a range of complementary information could be simultaneously obtained at a single molecule level. Here, we report the design, fabrication and application of a photonic–plasmonic device that is fully compatible with atomic force microscopy and Raman spectroscopy. Our approach relies on the generation and localization of surface plasmon polaritons by means of adiabatic compression through a metallic tapered waveguide to create strongly enhanced Raman excitation in a region just a few nanometres across. The tapered waveguide can also be used as an atomic force microscope tip. Using the device, topographic, chemical and structural information about silicon nanocrystals may be obtained with a spatial resolution of 7 nm.
A photonic–plasmonic device — which can be used as a tip for an atomic force microscope and also as a nanoscale light source for near-field Raman excitation — allows topographic, chemical and structural information to be obtained with a spatial resolution of 7 nm.
Journal Article
Application of enhanced recovery after surgery (ERAS) protocols in adrenal surgery: A retrospective, preliminary analysis
Abstract
Background:
The present study was conducted to evaluate the impact of enhanced recovery after surgery (ERAS) pathway in patients undergoing laparoscopic adrenalectomy (LA) for primary and secondary adrenal disease, in reducing the length of primary hospital stay and return to daily activities.
Materials and Methods:
This retrospective study was carried out on 61 patients who underwent LA. A total of 32 patients formed the ERAS group. A total of 29 patients received conventional perioperative care and were assigned as the control group. Groups were compared in terms of patient's characteristics (sex, age, pre-operative diagnosis, side of tumour, tumour size and co-morbidities), post-operative compliance (anaesthesia time, operative time, post-operative stay, post-operative numeric rating scale (NRS) score, analgesic assumption and days to return to daily activities) and post-operative complications.
Results:
No significant differences in anaesthesia time (P = 0.4) and operative time (P = 0.6) were reported. NRS score 24 h postoperatively was significantly lower in the ERAS group (P < 0.05). The analgesic assumption in post-operative period in the ERAS group was lower (P < 0.05). ERAS protocol led to a significantly shorter length of post-operative stay (P < 0.05) and to return to daily activities (P < 0.05). No differences in peri-operative complications were reported.
Discussion:
ERAS protocols seem safe and feasible, potentially improving perioperative outcomes of patients undergoing LA, mainly improving pain control, hospital stay and return to daily activities. Further studies are needed to investigate overall compliance with ERAS protocols and their impact on clinical outcomes.
Journal Article
Magnetic hot-spot generation at optical frequencies: from plasmonic metamolecules to all-dielectric nanoclusters
The weakness of magnetic effects at optical frequencies is directly related to the lack of symmetry between electric and magnetic charges. Natural materials cease to exhibit appreciable magnetic phenomena at rather low frequencies and become unemployable for practical applications in optics. For this reason, historically important efforts were spent in the development of artificial materials. The first evidence in this direction was provided by split-ring resonators in the microwave range. However, the efficient scaling of these devices towards the optical frequencies has been prevented by the strong ohmic losses suffered by circulating currents. With all of these considerations, artificial optical magnetism has become an active topic of research, and particular attention has been devoted to tailor plasmonic metamolecules generating magnetic hot spots. Several routes have been proposed in these directions, leading, for example, to plasmon hybridization in 3D complex structures or Fano-like magnetic resonances. Concurrently, with the aim of electromagnetic manipulation at the nanoscale and in order to overcome the critical issue of heat dissipation, alternative strategies have been introduced and investigated. All-dielectric nanoparticles made of high-index semiconducting materials have been proposed, as they can support both magnetic and electric Mie resonances. Aside from their important role in fundamental physics, magnetic resonances also provide a new degree of freedom for nanostructured systems, which can trigger unconventional nanophotonic processes, such as nonlinear effects or electromagnetic field localization for enhanced spectroscopy and optical trapping.
Journal Article
In Vitro Wear Properties of a New CAD/CAM Dental Resin Composite in a Chewing Simulation Test Opposing Itself
Wear resistance is of paramount importance for the long-term success of dental materials, especially when they are used for extensive indirect restorations in full-mouth rehabilitations. The present in vitro study aimed to evaluate the two-body wear resistance of a new and recently introduced CAD/CAM resin composite disc (Ena Cad, Micerium S.pA.), to compare it to the wear resistance of other two well-known and already marketed CAD/CAM composites (Brilliant Crios, Coltene/Whaledent AG; Grandio disc, Voco Gmbh) and to a conventional type 3 gold alloy (Aurocast 8, Nobil-Metal). Ten cylindrical specimens (diameter 8 mm, height 6 mm) were manufactured with each material and subjected to a two-body wear test in a dual-axis chewing simulator, performing 120,000 chewing cycles opposing antagonists (2-mm-diameter round tip) made out of the same corresponding materials. The total vertical wear (mm) and the total volumetric loss (mm3) for each sample/antagonist pair were calculated. Representative scanning electron microscope images were also taken. Data were statistically analyzed using one-way analysis of variance tests. No statistically significant differences were recorded among the wear properties of the restorative materials under investigation. The Ena Cad disc showed a wear resistance comparable to the type 3 gold alloy and to the already marketed Brilliant Crios and Grandio disc.
Journal Article
SERS discrimination of single DNA bases in single oligonucleotides by electro-plasmonic trapping
Surface-enhanced Raman spectroscopy (SERS) sensing of DNA bases by plasmonic nanopores could pave a way to novel methods for DNA analyses and new generation single-molecule sequencing platforms. The SERS discrimination of single DNA bases depends critically on the time that a DNA strand resides within the plasmonic hot spot. In fact, DNA molecules flow through the nanopores so rapidly that the SERS signals collected are not sufficient for single-molecule analysis. Here, we report an approach to control the residence time of molecules in the hot spot by an electro-plasmonic trapping effect. By directly adsorbing molecules onto a gold nanoparticle and then trapping the single nanoparticle in a plasmonic nanohole up to several minutes, we demonstrate single-molecule SERS detection of all four DNA bases as well as discrimination of single nucleobases in a single oligonucleotide. Our method can be extended easily to label-free sensing of single-molecule amino acids and proteins.
Sensing DNA bases by surface-enhanced Raman spectroscopy (SERS) in plasmonic nanopores has suffered from rapid flow through of molecules. Here, the authors attach DNA molecules to gold nanoparticles which, due to electro-plasmonic trapping, allow for controlled residence times and discrimination of single nucleotides.
Journal Article
Ultrasound generation in water via quasi-periodically snapping polymeric core–shell micro-bead excited with radiowaves
This work reports the results of a theoretical and numerical study showing the occurrence of stochastically resonating bistable dynamic in polymeric micro-bead of sub-micrometric size with stiff core and soft shell. The system, submerged in water, is excited with a pulsed laser working in the Mega-Hertz frequency range and tuned to match both an optical and acoustic resonance of the system. The laser interacts with the carbon nanotubes embedded in the shell of the polymeric micro-bead generating heat. The concurrent action of the generated heat with the standing acoustic oscillations, gives rise to a stochastically resonating bistable system. The system in fact is forced to switch between two states (identifiable with the creation and organized disruption of a quasi-hexagonal tessellation) via a snap-through-buckling mechanism. This phenomenon results in the unprecedented generation of pressure oscillations. These results open the way to develop a new type of core–shell micro-transducers for radioacoustic imaging applications able to work in the Mega-Hertz frequency range. From a more general thermodynamic perspective, the reported mechanism shows a remarkable periodicity and energy conversion efficiency.
Journal Article
Sensor Fusion-Based Machine Learning Algorithms for Meteorological Conditions Nowcasting in Port Scenarios
Modern port operations face increasing challenges from rapidly changing weather and environmental conditions, requiring accurate short-term forecasting to support safe and efficient maritime activities. This study presents a sensor fusion-based machine learning framework for real-time multi-target nowcasting of wind gust speed, sustained wind speed, and wind direction using heterogeneous data collected at the Port of Livorno from February to November 2025. Using an IoT architecture compliant with the oneM2M standard and deployed at the Port of Livorno, CNIT integrated heterogeneous data from environmental sensors (meteorological stations, anemometers) and vessel-mounted LiDAR systems through feature-level fusion to enhance situational awareness, with gust speed treated as the primary safety-critical variable due to its substantial impact on berthing and crane operations. In addition, a comparative performance analysis of Random Forest, XGBoost, LSTM, Temporal Convolutional Network, Ensemble Neural Network, Transformer models, and a Kalman filter was performed. The results show that XGBoost consistently achieved the highest accuracy across all targets, with near-perfect performance in both single-split testing (R2 ≈ 0.999) and five-fold cross-validation (mean R2 = 0.9976). Ensemble models exhibited greater robustness than deep learning approaches. The proposed multi-target fusion framework demonstrates strong potential for real-time deployment in Maritime Autonomous Surface Ship (MASS) systems and port decision-support platforms, enabling safer manoeuvring and operational continuity under rapidly varying environmental conditions.
Journal Article
Long-Term Results After Laparoscopic Sleeve Gastrectomy with Concomitant Posterior Cruroplasty: 5-Year Follow-up
Background
Hiatal hernia (HH) repair during laparoscopic sleeve gastrectomy (LSG) has been advocated to reduce the incidence of postoperative gastroesophageal reflux disease (GERD) and/or intrathoracic migration (ITM). The necessity of intraoperative repair in asymptomatic patients is still controversial. Previous, mid-term results of a prospective, comparative study evaluating posterior cruroplasty concomitant with LSG (group A 48 patients with simple vs. group B 48 reinforced with bioabsorbable mesh) confirmed the safety and effectiveness of simultaneous procedures. Present aim was to report the 60 months follow-up update, evaluating GERD and esophageal lesions’ incidence and HH’s recurrence.
Results
Follow-up was completed in 87.5% of the patients. Recurrent GERD was registered in 6/38 (15.7%, group A) and in 9/46 (19.5%, group B) (
p
= 1.0000). Grade A esophagitis and GERD was shown in 2 patients (5.2%), respectively 2 (4.3%) of each group (
p
= 1.0000), and recurrent HH was confirmed subsequently by contrast study and CT scan. Neither Barrett’s lesions nor de novo GERD was found in any patient. Failure of the cruroplasty with ITM was recorded in 7 patients from group A (18.4%) and 2 patients from group B (4.3%)
p
< 0.05; hence, a repeat posterior, reinforced cruroplasty was performed in all cases. A total of 12 patients (14.2%, 8 respective 4) were converted within 5 years for persistent/recurrent GERD, with only 1 case of de novo (group B).
Conclusions
Accurate patient selection and proper sleeve technique, combined with posterior cruroplasty (simple or reinforced) ensure effectiveness, with a rate of failure (HH recurrence) at 5 years of 10.7%.
Journal Article