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The X-ray Integral Field Unit (X-IFU) of the Advanced Telescope for High-ENergy Astrophysics (Athena) large-scale mission of ESA will provide spatially resolved high-resolution X-ray spectroscopy from 0.2 to 12 keV, with 5 ″  pixels over a field of view of 5 arc minute equivalent diameter and a spectral resolution of 2.5 eV (FWHM) up to 7 keV. The core scientific objectives of Athena drive the main performance parameters of the X-IFU. We present the current reference configuration of the X-IFU, and the key issues driving the design of the instrument.

Rodent premotor cortex (M2) integrates information from sensory and cognitive networks for action planning during goal-directed decision-making. M2 function is regulated by cortical inputs and ascending neuromodulators, including norepinephrine (NE) released from the locus coeruleus (LC). LC-NE has been shown to modulate the signal-to-noise ratio of neural representations in target cortical regions, increasing the salience of relevant stimuli. Using rats performing a two-alternative forced choice task after administration of a β-noradrenergic antagonist (propranolol), we show that β-noradrenergic signaling is necessary for effective action plan signals in anterior M2. Loss of β-noradrenergic signaling results in failure to suppress irrelevant action plans in anterior M2 disrupting decoding of cue-related information, delaying decision times, and increasing trial omissions, particularly in females. Furthermore, we identify a potential mechanism for the sex bias in behavioral and neural changes after propranolol administration via differential expression of β2 noradrenergic receptor RNA across sexes in anterior M2, particularly on local inhibitory neurons. Overall, we show a critical role for β-noradrenergic signaling in anterior M2 during decision-making by suppressing irrelevant information to enable efficient action planning and decision-making.

The X-ray Integral Field Unit (X-IFU) will operate an array of more than 3000 Transition Edge Sensor pixels at 90 mK with an unprecedented energy resolution of 2.5 eV at 7 keV. In space, primary cosmic rays and secondary particles produced in the instrument structure will continuously deposit energy on the detector wafer and induce fluctuations on the pixels’ thermal bath. We have investigated through simulations of the X-IFU readout chain how these fluctuations eventually influence the energy measurement of X-ray photons. Realistic timelines of thermal bath fluctuations at different positions in the array are generated as a function of a thermal model and the expected distribution of the deposited energy of the charged particles. These are then used to model the TES response to these thermal perturbations and their influence on the onboard energy reconstruction process. Overall, we show that with adequate heatsinking, the main energy resolution degradation effect remains minimal and within the associated resolution allocation of 0.2 eV. We further study how a dedicated triggering algorithm could be put in place to flag the rarer large thermal events.

We present the instrument simulator xifusim developed for the X-ray Integral Field Unit X-IFU aboard the planned Athena mission. xifusim aims to be an accurate representation of the entire instrument, starting from a full simulation of the Transition-Edge Sensor (TES) array receiving impact photons unconstrained by the small signal limit. Its output current is then propagated through the entire readout chain, including multiplexing, amplification and the digital readout. The final output consists of triggered records, which can be post-processed to reconstruct the photon energies. The readout chain itself is separated into individual, modular blocks with several possible models for each, allowing the simulation of different readout schemes or models of varying physical accuracy at the expense of run time. New models are implemented as necessary to enable studies of the overall readout chain. Such studies are also facilitated by fine-grained control of the simulation output, including the internal state of intermediate simulation blocks. In addition to its modularity, xifusim also allows the manipulation of certain internal parameters during a run, enabling the simulation of readout chain characterization measurements, environmental drifts or various kinds of crosstalk.

Up-/down-state transitions are a form of network activity observed when sensory input into the cortex is diminished such as during non-REM sleep. Up-states emerge from coordinated signaling between glutamatergic and GABAergic synapses and are modulated by systems that affect the balance between inhibition and excitation. We hypothesized that the endocannabinoid (EC) system, a neuromodulatory system intrinsic to the cortical microcircuitry, is an important regulator of up-states and sleep. To test this hypothesis, up-states were recorded from layer V/VI pyramidal neurons in organotypic cultures of wild-type or CB1R knockout (KO) mouse prefrontal cortex. Activation of the cannabinoid 1 receptor (CB1) with exogenous agonists or by blocking metabolism of endocannabinoids, anandamide or 2-arachidonoyl glycerol, increased up-state amplitude and facilitated action potential discharge during up-states. The CB1 agonist also produced a layer II/III-selective reduction in synaptic GABAergic signaling that may underlie its effects on up-state amplitude and spiking. Application of CB1 antagonists revealed that an endogenous EC tone regulates up-state duration. Paradoxically, the duration of up-states in CB1 KO cultures was increased suggesting that chronic absence of EC signaling alters cortical activity. Consistent with increased cortical excitability, CB1 KO mice exhibited increased wakefulness as a result of reduced NREM sleep and NREM bout duration. Under baseline conditions, NREM delta (0.5-4 Hz) power was not different in CB1 KO mice, but during recovery from forced sleep deprivation, KO mice had reduced NREM delta power and increased sleep fragmentation. Overall, these findings demonstrate that the EC system actively regulates cortical up-states and important features of NREM sleep such as its duration and low frequency cortical oscillations.

The X-IFU is the cryogenic spectrometer onboard the future ATHENA X-ray observatory. It is based on a large array of TES microcalorimeters, which work in combination with a Cryogenic AntiCoincidence detector (CryoAC). This is necessary to reduce the particle background level thus enabling part of the mission science goals. Here we present the first joint test of X-IFU TES array and CryoAC Demonstration Models, performed in a FDM setup. We show that it is possible to operate properly both detectors, and we provide a preliminary demonstration of the anti-coincidence capability of the system achieved by the simultaneous detection of cosmic muons.

We present a characterization of the sensitivity of TES X-ray micro-calorimeters to environmental conditions under frequency-domain multiplexing (FDM) readout. In the FDM scheme, each TES in a readout chain is in series with a LC band-pass filter and AC biased with an independent carrier at MHz range. Using TES arrays, cold readout circuitry and warm electronics fabricated at SRON and SQUIDs produced at VTT Finland, we characterize the sensitivity of the detectors to bias voltage, bath temperature and magnetic field. We compare our results with the requirements for the Athena X-IFU instrument, showing the compliance of the measured sensitivities. We find in particular that FDM is intrinsically insensitive to the magnetic field because of TES design and AC readout.

We present developments in the simulation of transition-edge sensor (TES) microcalorimeters under AC bias for the purpose of detector studies. The presented model extends the TES differential equation system by describing the TES as a resistively shunted junction, using the Josephson equations instead of a parametrized resistance. To demonstrate the performance of this model, we compare simulated and measured IV curves of a pixel characterized for the Athena X-ray Integral Field Unit and showcase the signal generated by a simulated X-ray pulse.

The Athena X-ray Integral Field Unit (X-IFU) will operate at 90 mK a hexagonal matrix of 3840 Transition Edge Sensor pixels providing spatially resolved high-resolution spectroscopy (2.5 eV FWHM up to 7 keV) between 0.2 and 12 keV. During the observation of very bright X-ray sources, the X-IFU detectors will receive high photon rates going up to several tens of counts per second per pixel and hundreds per readout channel, well above the normal operating mode of the instrument. In this paper, we investigate through detailed end-to-end simulations the performance achieved by the X-IFU at the highest count rates. Special care is notably taken to model and characterize pulse processing limitations, readout-chain saturation effects, as well as the non-Gaussian degradation of the energy redistribution from crosstalk at the focal plane level (both thermal and electrical). Overall, we show that the instrument performance should safely exceed the scientific requirements, and in particular that more than 50 % throughput at 1 Crab in the 5–8 keV band can be achieved with better than 10 eV average resolution with the use of a Beryllium filter, enabling breakthrough science in the field of bright sources.

Frequency-division multiplexing is the baseline read-out system for large arrays of superconducting transition-edge sensors (TES’s) under development for the X-ray and infrared instruments like X-IFU (Athena) and SAFARI, respectively. In this multiplexing scheme, the sensors are ac-biased at different frequencies from 1 to 5 MHz and operate as amplitude modulators. Weak superconductivity is responsible for the complex TES resistive transition, experimentally explored in great detail so far, both with dc- and ac-biased read-out schemes. In this paper, we will review the current status of our understanding of the physics of the TES’s and their interaction with the ac bias circuit. In particular, we will compare the behaviour of the TES nonlinear impedance, across the superconducting transition, for several detector families, namely: high-normal-resistance TiAu TES bolometers, low-normal-resistance MoAu TES microcalorimeters and high-normal-resistance TiAu TES microcalorimeters.