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Obsessive-compulsive disorder (OCD) is a prevalent condition with multifactorial etiology involving genetic and environmental factors. The present study aims to summarize the correlates of stressful life events (SLEs) in OCD by reviewing studies comparing OCD associated or not with SLEs before its onset. To do so, a systematic review was performed by searching PubMed, Web of Science, Scopus, and PsycINFO databases for studies published between the database’s inception and November 27, 2023. Studies including individuals whose OCD was precipitated or not by SLEs (SLEs OCD and NSLEs OCD, respectively) were assessed. Effect sizes or odds ratios were then calculated to identify the strength of association between SLEs and clinical characteristics, such as gender, age of onset, family history of OCD, severity of OCD symptoms, depressive symptoms, and mood comorbidities among patients with OCD. Out of the 4083 records initially identified, 5 studies met the inclusion criteria and 3 were comparable through a meta-analysis. Notably, the analyses were limited by the small number of studies available in the literature. The meta-analysis demonstrated SLEs OCD to be associated with female gender, later OCD onset, and increased comorbidity rates with mood disorders. Despite the cross-sectional nature of the reviewed studies, women may be more vulnerable to develop a later onset of OCD following SLEs, which may also lead to mood disorders. Caution is needed to avoid prematurely classifying this presentation as a distinct subtype of OCD.

This systematic review examined the existing literature to determine the evidence supporting the efficacy of online group treatments for anxiety-, obsessive-compulsive- and trauma-related disorders (AOTDs). A systematic review using the PUBMED, PsycInfo, Web of Science, and ClinicalTrials databases with no language, date, or study design filters was performed. The inclusion criteria comprised studies that examined individuals who had received a formal diagnosis of AOTDs, were aged 18 years or older, and had baseline and endpoint assessments of symptom severity using formal tools. Five studies on social anxiety disorder (SAD), four on post-traumatic stress disorder (PTSD) and one on tic disorders (TDs) were found. The studies were open-label ( = 2) and randomized controlled trials (RCTs) ( = 8), with five of the RCTs being non-inferiority trials. Most studies were conducted in the US and investigated psychological CBT based interventions via internet-based therapies (IBT: = 4), video teleconferencing (VTC: = 5) or a combination of both ( = 1). In SAD, IBT studies associated with a clinician assisted web-based forum (here termed \"forum-enhanced\" studies) were superior to waiting lists and not inferior to similar versions that were also \"forum enhanced\" but self-guided, \"telephone enhanced\" by a contact with a non-specialist, and \"email enhanced\" by a contact with a clinician individually. Studies involving VTC have shown comparable effectiveness to in-person interventions across some online group CBT based treatments for PTSD. Two open trials also demonstrated symptoms reductions of social anxiety and tics through VTC. There is evidence supporting the effectiveness of online group treatments for SAD and PTSD. Further studies from different research groups may be needed to replicate the use of these and other forms of online treatments in individuals with SAD, PTSD, and other clinical populations, such as OCD, panic disorder, agoraphobia and specific phobias. https://www.crd.york.ac.uk/prospero/, identifier CRD42023408491.

Background Individuals with obsessive–compulsive disorder (OCD) often feel compelled to perform (compulsive) behaviors, thus raising questions regarding their free will beliefs and experiences. In the present study, we investigated if free will related cognitions (free will beliefs or experiences) differed between OCD patients and healthy subjects and whether these cognitions predicted symptom changes after a one-year follow up. Methods Sixty OCD outpatients were assessed for their beliefs in and experiences of free will at baseline and after one year of treatment. A subsample of 18 OCD patients had their beliefs compared to 18 age and gender matched healthy controls. A regression analysis was performed to investigate whether free will cognitions at baseline were able to predict long-term OCD severity scores. Results Patients with OCD and healthy controls do not seem to differ in terms of their beliefs in free will (U = 156.0; p  = 0.864). Nonetheless, we found significant negative correlation between (i) duration of illness and strength of belief in determinism ( ρ  = -0.317; p  = 0.016), (ii) age and perception of having alternative possibilities ( ρ  = -0.275; p  = 0.038), and (iii) symptoms’ severity and perception of having alternative possibilities ( ρ  = -0.415; p  = 0.001). On the other hand, the experience of being an owner of ones’ actions was positive correlated with the severity of symptoms ( ρ  = 0.538; p  < 0.001) and were able to predict the severity of OCD symptoms at the follow up assessment. Conclusions Older individuals or those with a greater severity of symptoms seem to have a perception of decreased free will. In addition, patients with a longer duration of illness tend to have a lower strength of belief in determinism. Finally, the experience of being the owner of the compulsions, along with the baseline severity of symptoms, can be a predictor of a worse outcome in the OCD sample.

To (1) confirm whether the Habit, Reward, and Fear Scale is able to generate a 3-factor solution in a population of obsessive-compulsive disorder and alcohol use disorder (AUD) patients; (2) compare these clinical groups in their habit, reward, and fear motivations; and (3) investigate whether homogenous subgroups can be identified to resolve heterogeneity within and across disorders based on the motivations driving ritualistic and drinking behaviors. One hundred and thirty-four obsessive-compulsive disorder (n = 76) or AUD (n = 58) patients were assessed with a battery of scales including the Habit, Reward, and Fear Scale, the Yale-Brown Obsessive-Compulsive Scale, the Alcohol Dependence Scale, the Behavioral Inhibition/Activation System Scale, and the Urgency, (lack of ) Premeditation, (lack of ) Perseverance, Sensation Seeking, and Positive Urgency Impulsive Behavior Scale. A 3-factor solution reflecting habit, reward, and fear subscores explained 56.6% of the total variance of the Habit, Reward, and Fear Scale. Although the habit and fear subscores were significantly higher in obsessive-compulsive disorder (OCD) and the reward subscores were significantly greater in AUD patients, a cluster analysis identified that the 3 clusters were each characterized by differing proportions of OCD and AUD patients. While affective (reward- and fear-driven) and nonaffective (habitual) motivations for repetitive behaviors seem dissociable from each other, it is possible to identify subgroups in a transdiagnostic manner based on motivations that do not match perfectly motivations that usually described in OCD and AUD patients.

Background The nature and existence of free will have been debated for centuries. Since some psychiatric disorders are known to interfere with one’s ability to control their actions and thoughts (e.g., schizophrenia), the investigation of the psychiatric facet of free will beliefs seems to be relevant. In this systematic review, we were interested in clarifying if and how having a mental disorder affects individuals’ beliefs in free will by comparing psychiatric vs. non-psychiatric samples. Methods A systematic search of MEDLINE, Web of Science, EMBASE, and PsycINFO databases was performed between 04 and 09 November 2020. The search strategy included “free will” and related constructs and terms related to DSM-5 mental disorders characterized by psychotic, compulsive, avoidant, or impulsive symptoms. Eligible designs of studies included case-control and cohort studies. Study selection took place in committee meetings consisting of six researchers. Quality assessment of the selected studies was performed through the Joanna Briggs Institute Appraisal Checklist for Case Control Studies. Results After removing duplicates, a total of 12,218 titles/abstracts were screened. Inclusion and exclusion criteria were followed, and three articles were eventually selected. Conclusions It is not possible to provide unequivocal confirmation that having a mental disorder can or cannot affect someone’s belief in free will. Studies with different mental disorders should be conducted in this field. Systematic review registration PROSPERO CRD42018109468.

We investigated whether panic disorder (PD), obsessive-compulsive disorder (OCD), and social anxiety disorder (SAD) patients differ in the perception of their illnesses and whether these differences can be ascribed to levels of anxiety sensitivity. We performed a cross-sectional study comparing responses from 36 PD patients, 38 OCD, and 34 SAD patients in the Illness Perception Questionnaire-Mental Health (IPQ-MH). A MANCOVA model with the diagnostic group as the fixed factor, the IPQ-MH items as dependent variables, and the Anxiety Sensitivity Index-Revised (ASI-R) score as a covariate, was created. Significant differences were observed between the groups with respect to illness perception. PD patients showed significantly higher levels of anxiety sensitivity than other groups. However, after controlling for anxiety sensitivity as a covariate, patients with PD had significant lower scores in “personal control” and “treatment control” than patients with SAD. OCD patients did not differ significantly from both groups. PD, OCD, and SAD patients have both common and different perceptions regarding their illnesses. Differences between PD and SAD are related to controllability of symptoms, but seem not to be mediated by anxiety sensitivity. Future studies should investigate whether illness perceptions in OCD and anxiety disorders have therapeutic implications.

Circular RNAs (circRNAs) are dysregulated in complex diseases, so we investigated their global expression profile in stroke. Public RNA-Seq data of human ischemic stroke lesion tissues and controls were used to perform the global expression analysis. Target RNA binding proteins and microRNAs were predicted . Functional enrichment analysis was performed to infer the circRNAs’ potential roles. We found that circRNAs are potentially involved in synaptic components and transmission, inflammation and ataxia. An integrative analysis revealed that hsa_circ_0078299 and may be major players in the molecular stroke-context. Our results suggest a broad involvement of circRNAs in some stroke-related processes, indicating their potential as therapeutic targets to allow neuroprotection and brain recovery.