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The treatment of advanced lung cancer remains a major challenge in clinical medicine, justifying an urgent need for new therapeutic approaches. In a rather unique international collaboration, 43 patients with advanced lung cancer were treated using iodine-131-labeled tumor necrosis therapy chimeric antibody(131I-chTNT). Methods: Patients were treated either with intravenous (i.v.) infusion (n = 22), intratumoral injection using a computer tomography (CT)-guided catheter (n = 16), or combination i.v. and intratumoral infusion (n = 5). All patients, regardless of route of administration, received 2 doses of 131I-chTNT on days 1 and 14. Results: The results showed that of those patients receiving i.v. injection alone, 2 achieved partial response (PR) (9%), 16 had stable disease (73%), and 4 progressed (18%). Of those patients receiving intratumoral injection only, 1 had a complete response (CR) (6%), 8 achieved PR (50%), 7 had stable disease (44%), and none (0%) progressed. Finally, of those patients receiving both i.v. and intratumoral administration, 1 had a CR (20%), 1 achieved PR (20%), 2 had stable disease (40%), and 1 (20%) showed progression. Conclusions: These promising results demonstrate that sufficient doses of radiolabeled antibody can be safely delivered to tumors to cause significant therapeutic effects in advanced lung cancer.

Q I was with my friend when I spotted this really hot guy. He spotted my friend. After that, they flirted day in and day out. But when he asked her out, she said no. Then he and I flirted. We made out once, and then he started calling me. But after I started calling him, he wanted nothing to do with me. He won't even talk to me online. The worst part is, we go to the same temple. What should I do?

Watching his exceptional management of the game during the World Cup got me thinking about the crossover between the skills of a referee managing a team on the pitch and those of a business leader managing a team in the office. Making decisions under pressure During the Rugby World Cup, Owens has had to make tough decisions under intense pressure and tight timescales.

[Jane T. Elfers], president and chief executive officer of Lord & Taylor, quietly checked out her new Downtown store last week and was duly awed. Her vision of the core customer tends to be someone like herself. Elfers is married and the mother of an almost 4-year-old girl. Those personal experiences tell her the Lord & Taylor woman needs good clothes but doesn't want a lot of hassle in shopping for them. That means focusing on service -- The New York Times recently called Lord & Taylor staff \"shockingly courteous\" -- and hassle-free shopping. Elfers doesn't want to see clutter and she promises products organized by category.