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Principles of management for the hospitality industry
'Principles of Management for the Hospitality Industry' is designed specifically for hospitality students who need to be able to use management tools and techniques to become successful hospitality managers.
Book
Scanning probe microscopy of soft matter
Well-structured and adopting a pedagogical approach, this self-contained monograph covers the fundamentals of scanning probe microscopy, showing how to use the techniques for investigating physical and chemical properties on the nanoscale and how they can be used for a wide range of soft materials.
eBook
Searches for the light invisible axion-like particle in K+→π+π0a decay
A high-statistics data sample of the
K
+
decays is recorded by the OKA collaboration. A missing mass analysis is performed to search for a light invisible pseudoscalar axion-like particle (ALP)
a
in the decay
K
+
→
π
+
π
0
a
. No signal is observed, and the upper limits for the branching ratio of the decay are calculated. The
90
%
confidence level upper limit changes from
2.5
·
10
-
6
to
2
·
10
-
7
for the ALP mass from 0 to 200 MeV/
c
2
, except for the region of
π
0
mass, where the upper limit is
4.4
·
10
-
6
.
Journal Article
Observation of K+→π+π0π0γ decay
The
K
+
→
π
+
π
0
π
0
γ
decay is observed by the OKA collaboration. About 60 events of the decay observed with signal:noise
≈
1
. The branching ratio obtained by normalization to
K
+
→
π
+
π
0
π
0
is measured to be
(
3.7
±
0.9
(
s
t
a
t
)
±
0.3
(
s
y
s
t
)
)
×
10
-
6
for
E
γ
∗
>
10
MeV
. The branching ratio,
γ
energy spectrum and angular distribution are consistent with ChPT prediction.
Journal Article
Study of K+→π0e+νγ decay with OKA setup
Results of a study of the K+→π0e+νγ decay at OKA setup are presented. More than 32,000 events of this decay are observed. The differential spectra over the photon energy and the photon–electron opening angle in kaon rest frame are presented. The branching ratios, normalized to that of Ke3 decay are calculated for different cuts on Eγ∗ and cosΘeγ∗. In particular, the branching ratio for Eγ∗>30 MeV and Θeγ∗>20∘ is measured R = Br(K+→π0e+νeγ)Br(K+→π0e+νe) = = (0.587±0.010(stat.)±0.015(syst.))×10-2, which is in a good agreement with ChPT O(p4) calculations.
Journal Article
South Asian languages : a syntactic typology
\"South Asian languages are rich in linguistic diversity and number. This book explores the similarities and differences of about forty languages from the four different language families (Austro-Asiatic, Dravidian, Indo-Aryan [Indo- European], and Tibeto-Burman [Sino-Tibetan]). It focuses on the syntactic typology of these languages and the high degree of syntactic convergence, with special reference to the notion of \"India as a linguistic area.\" Several areas of current theoretical interest such as anaphora, control theory, case and agreement, relative clauses, and the significance of thematic roles in grammar are discussed. The analysis presented has significant implications for current theories of syntax, verbal semantics, first and second language acquisition, structural language typology, and historical linguistics. The book will be of interest to linguists working on the description of South Asian languages, as well as syntacticians wishing to discover more about the common structure of languages within this region\"-- Provided by publisher.
Book
Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies
Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to full-length antibodies limit their therapeutic potential. In this study, scFv fragments of GD2-specific antibodies 14.18 were produced in a mammalian expression system that specifically bind to ganglioside GD2, followed by site-directed pegylation to generate mono-, di-, and tetra-scFv fragments. Fractionated pegylated dimers and tetramers of scFv fragments showed significant increase of the binding to GD2 which was not accompanied by cross-reactivity with other gangliosides. Pegylated multimeric di-scFvs and tetra-scFvs exhibited cytotoxic effects in GD2-positive tumor cells, while their circulation time in blood significantly increased compared with monomeric antibody fragments. We also demonstrated a more efficient tumor uptake of the multimers in a syngeneic GD2-positive mouse cancer model. The findings of this study provide the rationale for improving therapeutic characteristics of GD2-specific antibody fragments by multimerization and propose a strategy to generate such molecules. On the basis of multimeric antibody fragments, bispecific antibodies and conjugates with cytotoxic drugs or radioactive isotopes may be developed that will possess improved pharmacokinetic and pharmacodynamic properties.
Journal Article