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Case summary A 7-month-old intact male Maine Coon cat was presented because of intermittent pyrexia, hyporexia and lethargy. On abdominal palpation, both kidneys appeared to be enlarged with an irregular shape. Haematology and serum biochemistry showed anaemia, hypoalbuminaemia and hyperproteinaemia. Ultrasonographic findings included multiple perirenal cyst-like lesions, heterogenous cortices with cortical striation and a medullary band sign, as well as renomegaly. The cat was euthanased and a limited necropsy of the kidneys revealed pyogranulomatous lesions, which were confirmed to be related to feline infectious peritonitis (FIP) by immunohistochemistry. Relevance and novel information To the authors’ knowledge, this is the first published report describing perirenal cyst-like lesions of the kidneys related to FIP.

Background Halicephalobus gingivalis is a nematode with zoonotic potential which can cause fatal opportunistic infections in various mammals. The parasite has never been diagnosed in Sweden, in any species, prior to the presented case. Case presentation An imported 21-year-old Icelandic mare developed severe neurological signs. The horse was eventually euthanized and submitted for post-mortem examination where severe lesions in the kidneys were noted. Histopathology revealed the presence of H. gingivalis in both kidneys and the brain. Phylogenetic analysis of the parasite determined it to belong to Lineage 1. Conclusions With the occurrence of H. gingivalis in Sweden, the disease should be added to the list of differential diagnoses in cases with acute onset of neurological disease in both horses and other mammals including humans.

Background Lymphoma is one of the most common malignancies in dogs, but ovarian lymphoma is exceedingly rare, with only a few reported cases. Most canine lymphomas are of B-cell origin, whereas T-cell lymphomas are generally associated with a more aggressive clinical course. Protein-losing enteropathy (PLE) is a well-documented cause of hypoalbuminemia in dogs, often resulting from lymphangiectasia or chronic enteropathies. The potential relationship between chronic immune-mediated disease and the development of lymphoma remains unclear. Case presentation A 10-year-old intact female Miniature Poodle presented with chronic diarrhea, ascites and hypoalbuminemia. Abdominal ultrasound revealed severe intestinal mucosal striation, consistent with PLE, but no evidence of neoplasia. The dog was treated with methylprednisolone, chlorambucil, and cyclosporine, achieving long-term clinical stability. Fourteen months after initial presentation, the dog developed acute gastrointestinal signs, and ultrasound revealed an ovarian mass. Cytology, histopathology, and immunohistochemistry confirmed a diagnosis of ovarian T-cell lymphoma. No other neoplastic lesions were detected at that time raising the possibility of a primary ovarian origin, though widespread disease at necropsy suggests secondary involvement. The dog remained clinically stable for five months after lymphoma diagnosis but ultimately developed widespread disease, including hepatic, splenic, and adrenal involvement, leading to euthanasia. Necropsy confirmed multi-organ dissemination of the T-cell lymphoma, while histopathology of the intestines revealed signs of chronic lymphangiectasia but no definitive diagnosis of intestinal lymphoma. Conclusions This case highlights the diagnostic challenges of extranodal lymphoma in dogs and the importance of considering neoplasia in cases of chronic protein-losing enteropathy. The potential role of chronic inflammation and long-term immunosuppressive therapy in lymphomagenesis remains unclear and warrants further study.

A 10-month-old female intact Australian shepherd dog was diagnosed with an intrapelvic mass. Blood and urinanalyses were unremarkable. A contrast-enhanced CT scan was performed to define the extent of the mass. A large, expansile, heterogeneous mass, extending from the ventral aspect of the last lumbar vertebra until the second caudate vertebra and invading the vertebral canal at the lumbosacral junction with displacement of all organs in the caudal abdomen, was diagnosed. Two days after the CT scan, the dog was euthanased because of deterioration of clinical signs despite the start of multimodal analgesia. Necropsy and subsequent histology and immunohistochemistry revealed the presence of a plasmacytoma and haemorrhagic cystitis. The haemorrhagic cystitis was most likely caused by the contrast agent used for the CT scan that remained in the bladder for a prolonged time, secondary to subobstruction of the urethra.

Background:Halicephalobus gingivalis is a nematode with zoonotic potential which can cause fatal opportunistic infections in a wide variety of mammals. The parasite has never been diagnosed in Sweden, in any species, prior to the presented case.Case presentation:An imported 21-year-old Icelandic mare developed severe neurological symptoms. The horse was eventually euthanized and submitted for post-mortem examination where severe lesions in the kidneys was noted. Samples for histological examination were submitted, which revealed the presence of H. gingivalis in both renal and brain tissue. Phylogenetic analysis of the parasite determined it to belong to Linage 1.Conclusions:With the occurrence of H. gingivalis in Sweden, the disease should be added to the list of differential diagnoses in cases with acute onset of neurological disease in both horses and mammals including humans.

The addition of the oral proteasome inhibitor ixazomib to a regimen of lenalidomide plus dexamethasone led to a significant prolongation of progression-free survival of almost 6 months, as compared with placebo, with a small increase in the risk of thrombocytopenia. Outcomes of multiple myeloma have improved substantially over the past 15 years with the introduction of proteasome inhibitors and immunomodulatory drugs, 1 , 2 and these agents now form the backbone of therapy for multiple myeloma. 3 In phase 3 studies, triplet regimens based on these agents were shown to be more efficacious than doublet regimens when these regimens were used as a first-line treatment 4 – 6 and in relapsed disease. 7 , 8 In addition, there has been a shift in treatment patterns toward the use of extended treatment to further improve long-term outcomes, 9 and this shift highlights the need for additional effective agents with . . .

[...]the book is well illustrated. [...]a lengthy bibliography is given. An attempt was made by means of individual interviews and participant observations, both on college and university campuses and in private homes, to ascertain which social factors determine the attitudes and aspirations of the girls with relation to marriage, family life and career. 526 BOEKBESPREKINGEN Apart from a description af the purpose of the research, the methods of investigation and the results thereof, the book has a brief introductory chapter on the City of Jaipur and one on the University of Rajasthan, including a diagram of the educational system, starting from the lower primary school, and also a table of the percentage of pupils enrolled in secondary education in the whole of India and in Rajasthan. The book presents 25 tables including one on illiteracy and secondary school enrolment in India employment and income of the girls' fathers or guardians employment and family composition student attitudes towards the joint-family system related successivelyto: level of study, family background, fathers' employment, fathers' income advantages of joint living disadvantages of joint living opinions regarding the selection of marriage partners opinions and qualities desired in the marriage partner occupations considered most suitable for women.