Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
77
result(s) for
"الأسبرين"
Sort by:
Potential Therapeutic Effect of Resveratrol on Aspirin Induced Acute Gastric Ulcer in Rats
This study aimed to evaluate the potential therapeutic effect of Resveratrol in treating aspirin-induced acute gastric ulcers in male albino rats, through physiological, biochemical, and histopathological assessments. A total of 24 Sprague-Dawley rats were divided into four groups: a normal control, an aspirin-induced ulcer group (200 mg/kg body weight), and two groups treated orally with Resveratrol at doses of 25 and 50 mg/kg daily. At the end of the experiment, gastric tissue was examined, and ulcer length, gastric juice volume, pH, and total acidity were measured, in addition to oxidative and inflammatory markers. Results revealed that the aspirin group exhibited significant increases in ulcer length and gastric secretion volume with a marked decrease in gastric pH, while Resveratrol administration notably ameliorated all ulcerative parameters. Treated rats showed shortened ulcer length, reduced secretion, elevated pH, and improved antioxidant and anti-inflammatory profiles. Histopathological examination confirmed mucosal restoration and reduced hemorrhagic and necrotic areas. The higher dose (50 mg/kg) demonstrated superior protective and healing effects compared to the lower one. The study concluded that Resveratrol exerts strong protective and curative effects against aspirin-induced gastric ulcers, primarily due to its antioxidant and anti-inflammatory properties and its ability to promote mucosal regeneration. Further studies were recommended to confirm its potential as a natural adjunct therapy for NSAID-induced gastric injury. Abstract Written by Dar AlMandumh, 2025, Using AI.
Journal Article
Massive hyphaema following laser iridotomy in a patient on dual antiplatelet therapy (aspirin plus ticagrelor) : case report and literature review
Massive hyphaema presentation after a laser iridotomy is very rare. We report a 63-year-old man with
ischaemic heart disease on dual antiplatelet therapy (aspirin plus ticagrelor) who was diagnosed as a primary angle-closure
suspect and was to undergo a neodymium-doped yttrium aluminium garnet laser iridotomy at Centro Oftalmologico
Virgilio Galvis, Floridablanca, Colombia in 2016. While performing the iridotomy in the left eye, active bleeding occurred
that finally filled approximately 75 % of the anterior chamber. Intraocular pressure (IOP) increased to 62 mmHg. Mannitol
and a topical dorzolamide / timolol were used to control the increase in IOP. The hyphaema slowly resolved over the
following week without sequelae. This case revealed that massive hyphaema can complicate laser iridotomy in patients on
dual antiplatelet therapy, although this is rare. Therefore, if patients are taking aspirin and ticagrelor, it would be advisable
to stop the second medication if possible. In addition, sequential application of photocoagulation and photodisruption
lasers might diminish the risk of significant bleeding.
Journal Article
Evaluation of the efficacy of aspirin and low molecular weight heparin in patients with unexplained recurrent spontaneous abortions
Background : the roles of inflammatory cytokines and local placental thrombosis in patients with unexplained recurrent spontaneous abortion (URSA) have been shown. Since low molecular weight heparin (LMWH) and acetyl salicylic acid (ASA) have both anti-inflammatory and anti-coagulant effect, we evaluated their efficacy in patients with URSA.
Methods : one hundred patients with a history of URSA referring to Obstetrics Clinic affiliated to Shiraz University of Medical Sciences between 2004 and 2009 were randomly divided into two groups. Fifty patients in thromboprophylaxis group were treated with LMWH (5000 unit ; twice a day), ASA (80 mg daily) and calcium supplement (500 mg daily) after detection of fetal heart beat. Another 50 patients received no thromboprophylaxis. Live birth rate, obstetrical complications, prenatal and neonatal complications and hemorrhagic side effects were recorded.
Results : both groups were matched for mean age and mean number of pervious abortions. Thromboprophylaxis group had a higher rate of live birth (83.7%) in comparison to the control group (54%). No maternal or neonatal side effects were seen. There were no differences in obstetrical complications, prenatal and neonatal complications between the two groups.
Conclusion : Thromboprophylaxis with ASA and LMWH seems to be safe and effective in patients with URSA.
Journal Article
Antioxidant properties of indole- 3 - carbinol on hepatotoxicity induction in experimental animals
Indole-3-carbinol was found to have possible anticarcinogenic, antioxidant and antiatherogenic effects on the organism. The aim of the present study investigation is to evaluate the protective effect of indole-3-carbinol (I3C) against aspirin (ASA) induced effects on rat liver. Male albino rats were randomly divided into four groups of 6 animals in each. The control rats (group 1) were orally administration of distilled water for seven days and the experimental rats (groups 2-4) were treated with ASA at a dose of 500 mg/kg/body weight and I3C at a dose of 20 mg/kg/body weight either alone or in combination with each other orally, once daily for seven consecutive days. Results of the present study showed that groups treated with indole-3-carbinol possessed protective activity possibly as evidenced by the reduction of histopathological alteration and showed normal histological structure of liver. This work suggest that I3C possesses significant hepatoprotective and antioxidant properties on hepatotoxicity induction by ASA in male albino rats.
Journal Article
Effects of Omeprazole on Healing of Non-Steroidal Anti-Inflammatory Drug \NSAID\
Gastric hyperacidity and gastroduodenal ulcer is a very common global problem today. It is now generally agreed that gastric lesions develop when the delicate balance between some gastroprotective and aggressive factors are lost. The objective of present study is to evaluate the effects of omeprazole on healing of non-steroidal anti-inflammatory drug (aspirin) induced peptic ulceration in adult male albino rats and gastro protective role of indole-3-carbinol. Male albino rats were randomly divided into two main groups; control group administrated distilled water and ulcerated group administrated aspirin at a dose of 500 mg/kg/body weight for seven consecutive days. Aspirin administration was stopped after 7 days representing the initial duration for the experiment and was followed by the beginning of different experimental regimens for a total experimental duration of 26 days. Results of the present study showed that, groups treated with omeprazole alone accelerated ulcer healing by inhibiting gastric acid secretion but indole-3-carbinol (I3C) possessed protective activity possibly as evidenced by the reduction of histopathological alteration of stomach and duodenum tissues and inhibition of gastric acid secretion. This study provides a strong evidence of indole-3carbinol which showed significant gastro protective and antioxidant activities against aspirin induced peptic ulceration in male albino rats.
Journal Article
