Explore the vast range of titles available.

The current study looked at the preventive effects of aqueous extracts of Psidium guajava leaves (EEPGL) and Artemisia annua on gentamicin-induced nephrotoxicity in rats. Thirty-six male albino rats were separated into two major groups as follows: (The first core group of six rats) This primary group was fed a basal diet and served as the control group. (The second major group (30 rats): This main group was fed a basal diet and administered gentamicin (GM) intraperitoneally at a dose rate of 80 mg/kg body weight of rat for 8 consecutive days to induce nephrotoxicity. The rats in the second major group (30 rats) were then divided into into five subgroups (each group had six rats) as follows: Group 1 was fed on B.D. and kept as the control (+ve) group.Group 2: fed on B.D. and treated with 250 mg/kg b.w. of guava leaf aqueous extract daily; Group 3: fed on B.D. and treated with 500mg/kg b.w. of guava leaf aqueous extract daily; Group 4: fed on B.D. and treated with Artemisia extract orally 100 mg/kg b.w. daily; and Group 5: fed on B.D. and treated with Artemisia extract orally 200 mg/kg b.w. daily. The current studies demonstrated that guava 500 mg/kg normalized AST, ALT, and ALP similarly to healthy control, while Artemisia 200 mg/kg exhibited comparable efficacy.Guava 500 mg/kg reduced serum urea, uric acid and creatinine, while Artemisia 200 mg/kg achieved near-normal levels of urea, uric acid and creatinine. Both Psidium guajava and Artemisia annua extracts demonstrated significant nephroprotective and hepatoprotective effects against gentamicin-induced toxicity. Higher doses (500 mg/kg guava, 200 mg/kg Artemisia) were most effective, restoring biochemical, histological, and antioxidant parameters to near-normal levels. This study concluded that: Aqueous extracts of Psidium guajava and Artemisia annua leaves effectively mitigated gentamicin-induced nephrotoxicity in rats. Higher doses (500 mg/kg guava and 200 mg/kg Artemisia) showed the greatest protective effects, restoring kidney and liver function markers, as well as antioxidant and histological parameters, to near-normal levels.

Nanoparticles are compounds with special qualities that are very small in size (less than 100 nm). As a result, nanoparticles pose many different health concerns. Therefore, this study aimed to estimate basil leaf extract's protective effect on nephrotoxicity tempted by zinc oxide nanoparticles (ZnONPs) in male albino rats. Twenty-four male Sprague Dawley rats were divided into four groups. Group 1 rats were given a basal diet for 4 weeks and served as normal control. Group 2 rats were fed on a basal diet+ 500mg/ kg b.w. from leaves extract by gavage) for 4 weeks. Group 3 rats have a single dose of ZnONPs (600 mg/kg i.p.) on the 29th day. Group 4 rats received a single dose of ZnONPs (600 mg/kg i.p.) on the 29th day+ 500 mg/ kg b.w. leaf extract via gavage for 4 weeks. At the end of the experiment, blood samples were taken, internal organs were collected, weighted. A complete blood count was performed. Serum was separated to biochemical examination. Basil leaves extract recorded the highest catechein, benzoic, P-OH-benzoic, ellagic and gallic acids, respectively. Serum creatinine, uric acid, urea, zinc, Calcium, magnesium, sodium, potassium and the renal levels of malondialdehyde increased after injection of ZnONPs, reduced hemoglobin, creatinine clearance, zinc's renal activity and antioxidant enzymes. On the other hand, the administration of basil leaves extract improved kidney functions and renal antioxidant enzymes. Therefore, basil leaves extract can be used as a potential preventive agent against ZnONPs induced nephrotoxicity.

Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueousethanolic extract of N. sativa and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive Vitamin E (100 mg/kg), preventive N. sativa (100,200 mg/kg), preventive + treatment Vitamin E, and preventive + treatment N. sativa (100, 200 mg/kg). Duration of this study was 11 days and cisplatin was injected on the 6th day of the experiment. Tissue damage in all groups that received N. sativa extract and Vitamin E showed a significant improvement compared with the cisplatin group. In addition, serum and tissue total thiol content in preventive and preventive + treatment N. sativa groups showed significant increase compared with cisplatin group. There was no significant difference in serum malondialdehyde concentration of the control rats compared with the preventive and preventive + treatment N. sativa groups. N. sativa extract and viamin E improved the pathology and oxidative stress in the rat kidney. However, more studies are needed to determine the mechanism of action of N. sativa on cisplatin-induced kidney toxicity

Background: some data suggest the protective effect of portulaca oleracea against renal failure and its association with the preservation of the renal antioxidant status and the regulation of apoptosis. objectives: the current study aimed to examine the renoprotective effects of treatment with portulaca oleracea (po), a prominent hydrogen sulfide donor, in a 5/6 nephrectomy animal model. methods: in this experimental study, 32 adult male wistar rats, initially weighting 200 - 250 g, were housed under standard conditions since the beginning of april 2017 until the end of january 2018. the effect of po extract on renal dysfunction induced by gentamicin was studied. the male rats were treated with two selected doses of po (i.e., 200 and 600 mg/kg p.o.) and normal saline (5 ml/kg p.o.) for 28 consecutive days. gentamicin (80 mg/kg/day intraperitoneally [i.p.]) was administered to two groups for seven days, and they were considered as the po200 and po600 gentamicin groups, respectively, while the group administered normal saline (5 ml/kg p.o.) for 35 consecutive days was considered as the control group. the rats were anesthetized on day 36. then, they were sacrificed under deep anesthesia, and plasma and tissue samples were obtained. results: treatment with po decreased the renal histological damages and apoptosis induced by gentamicin and enhanced renal function parameters compared to the gentamicin group. conclusions: the present findings provide strong evidence to support the traditional medicinal use of this herb by the tribal people in the treatment of renal impairment. finally, these results support the therapeutic effect of po in preventing the development of renal dysfunction.