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Portulaca oleracea L. is a commonly used a medicinal food, pharmacological effects, including, anti-inflammatory, antioxidant and neuropharmacological were previously reported. Aluminium chloride (AlCl3) interferes with the activities of neurons by disturbing proinflammatory cytokines and oxidative stress .Alzheimer's disease (AD) remains the most incurable neurodegenerative disorder, AlCl3 is an established chemical agent for the induction of pathological characteristics typical of AD. The present study was designed to investigate the effect of the P. oleracea extracts (EEPO) on aluminum chloride (AlCl3)-induced neurotoxicity in male rats. Twenty four adult albino male rats Sprague- Dawley strain average weight (180 ± 5 g) were purchased and kept under observation. Six rats served as negative control group (-ve) and eighteen rats were administered orally with aluminum chloride (AlCl3) 17 mg/ kg body weight daily for 45 days to induce AD Then, rats reclassified into control positive group(+ve) and tow treated rat groups which administered ethanolic extract of (EEPO) at 200 & 400 mg/kg bw day. The treatment period was designed for 15 days. The neurocognitive function of all groups to the Tmaze test which was done thrice: at zero time before starting oral induction with AlCl3, after AD-induction period by 24 h, and 24 h after the last oral treatment with the (EEPO). Behavioral observations were recorded before and at the end of the experiment. The results revealed that the treated group with (EEPO) 400 mg/kg significantly reduce the levels of inflammatory markers when compared to 200 mg/kg, also a significant decrease in (MDA) were observed in high dose (400 mg/ kg) when compared with (200 mg/ kg) at (p<0.05). Antioxidants biomarkers in treated groups were significant increased at (p < 0.05) compared to positive group (+ve). It was found that the highest significant increase seen in treated with (400 mg/ kg) of EEPO compared to (200 mg/ kg). On the other hand, T-maze, test clear that a significant increase in time (seconds) taken by rats to reach the food in positive group (+ve) compared to positive group (-ve), opposite treated groups with EEPO showed a significant decrease in time indicated. Therefore we recommended taking Portulacaoleracea plant to reduce the symptoms associated with Alzheimer's disease.