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Objective: The aim of this study was to investigate the effectiveness of the Portage Training Program in enhancing the abilities of Down syndrome children. In addition, the study aimed at studying the differential effect of the program among the program's domains in terms of the duration of the children's enrollment in the program. Methods: The study sample consisted of 27 Down Syndrome children (12 boys, 15 girls) who were enrolled in the Portage Program. They were later categorized into three groups based on the duration of time they spent in the training program (26 weeks or less, 27 to 30 weeks, and more than 30 weeks). The children's abilities were assessed before and after entering the program. One-way ANOVA test was used to test the study's hypotheses. Results: The study found out that there were significant differences in the level of enhancement among the three groups based on the duration of training (p < .05) in the motor, language and socialization domains. However, the differences in the infant stimulation, cognitive and self-help domains were not significant. In addition, results showed that the group that spent more than 30 weeks in the program had the highest level of enhancement. These results indicated that the more time spent in the training, the more the benefit gained by the child.