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The aims of study to determine the cardioprotective effects of rutin and mesenchymal stem cells on acetaminophen induced cardiac enzymatic damage in rats. seventy male rats were divided into two studies. One: twenty young male rats were used as a source of bone marrow-derived MSCs. Two: fifty adult male rats were divided into five groups: G1: control group; G2: rats were given of PARA (750 mg/kg b.w.) every 72h orally for 21 days, then left for 30 and 60 days without any treatment; G3: rats were given of PARA then, administrated of rutin (25mg/kg b.w/d) for 30 and 60 days; G4: rats were given of PARA then, injected by BM-MSCs (1.5x 106 cells in 0.5 PBS) in the tail vein for 30 and 60 days, and G5: rats were given of PARA then, injected by BM-MSCs in the tail vein, and then administrated of rutin orally for 30 and 60 days. Treated by the PARA showed, a significant increased the CK-MB and LDH levels when compared with normal rats at 30 and 60 days. While, the PARA+MSCs+RTN group showed, a significant decrease in the CK-MB and LDH levels as compared with other groups rats at 30 and 60 days. Rats treated with both MSCs and RTN after treated by PARA showed, a markedly improved in cardiac enzymes activity.