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Diabetes mellitus (DM) is defined as a state in which homeostasis of carbohydrate and lipid metabolism is improperly regulated by insulin. The present study was designed to investigate the effect of brown algae (Sargassum subrepandum) powder (BAP) on DM and is complications (hyperlipidemia and immune disturbances) induced by alloxan in rats.Thirty six rats were divided into two main groups, the first group (Group 1, 6 rats) still fed on basal diet (BD) and the second main group (30 rats) was with alloxan then classified into five sub groups as follow: group (2), fed on BD as a model control, and groups (3, 4, 5 and 6) fed on BD containing 2.5, 5.0, 7.5 and 10 % BAP, respectively. At the end of the experiment (4 weeks), treatment of rats with alloxan, model control group, induced a significant (p≤0.01) increasing in serum glucose concentration by the ratio 165.38% compared to normal control group. Dietary intervention with BAP (2.5, 5.0, 7.5 and 10%) in rats for 28 days led to significantly (p≤0.05) decreasing the levels of serum glucose which recorded 155.71, 137.08, 108.64 and 91.14% compared to the normal control group, respectively. The rate of decreasing in serum glucose was exhibited a dose- dependent increase with the levels of BAP intervention. Also, BAE was effective in protecting against DM complications including serum lipid profile (TG, TC, HDL-c, LDL-c and VLDL-c) and serum immunological parameters (Alb and TNF-α). Therefore, we recommended like of that algae powder by a concentrations up to 10% to be included in our daily diets, drinks and food supplementation.