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We aimed to prospectively evaluate the influence of holmium laser enucleation of the prostate （HoLEP） on the overall postoperative sexual function of benign prostatic hyperplasia （BPH） patients with lower urinary tract symptoms （LUTS） and to explore the relationship between sexual function and LUTS. From January 2010 to December 2011, sixty sexually active consecutive patients with BPH who underwent HoLEP were prospectively enrolled in the study. All patients filled out the Male Sexual Health Questionnaire （MSHQ） for evaluation of their overall sexual function and the International Prostatic Symptom Score （IPSS） for pre- and post-operative 6 months evaluation of their voiding symptoms. The LUTS and sexual function changes were statistically analyzed. The preoperative and 6 months postoperative status of the patients was compared using uroflowmetry and IPSS questionnaires. The analysis revealed significant improvements following HoLEP. Among the sub-domains of the MSHQ, postoperative sexual function, including erection, ejaculation, sexual satisfaction, anxiety or sexual desire, did not significantly change after HoLEP （P 〉 0.05）, whereas satisfaction scores decreased slightly due to retrograde ejaculation in 38 patients （63.3%）. Sexual satisfaction improved significantly and was correlated with the improvements of all LUTS and the quality-of-life （QoL） domains in IPSS after surgery （QoL; relative risk [RR]： -0.293; total symptoms, RR： -0.411; P 〈 0.05）. The nocturia score was associated with the erectile function score （odds ratio 0.318, P = 0.029）. The change in ejaculatory scores did not show significant association with IPSS scores. HoLEP did not influence overall sexual function, including erectile function. In addition, sexual satisfaction improved in proportion with the improvement of LUTS.

Non-traumatic injury accounts for approximately half of clinical spinal cord injury, including chronic spinal cord compression. However, previous rodent spinal cord compression models are mainly designed for rats, few are available for mice. Our aim is to develop a thoracic progressive compression mice model of spinal cord injury. In this study, adult wild-type C57BL/6 mice were divided into two groups： in the surgery group, a screw was inserted at T9 lamina to compress the spinal cord, and the compression was increased by turning it further into the canal（0.2 mm） post-surgery every 2 weeks up to 8 weeks. In the control group, a hole was drilled into the lamina without inserting a screw. The results showed that Basso Mouse Scale scores were lower and gait worsened. In addition, the degree of hindlimb dysfunction in mice was consistent with the degree of spinal cord compression. The number of motor neurons in the anterior horn of the spinal cord was reduced in all groups of mice, whereas astrocytes and microglia were gradually activated and proliferated. In conclusion, this progressive compression of thoracic spinal cord injury in mice is a preferable model for chronic progressive spinal cord compression injury.

Tongguan Liqiao acupuncture therapy has been shown to effectively treat dysphagia after stroke-based pseudobulbar paralysis. We presumed that this therapy would be effective for dysphagia after bulbar paralysis in patients with brainstem infarction. Sixty-four patients with dysphagia following brainstem infarction were recruited and divided into a medulla oblongata infarction group（n = 22）, a midbrain and pons infarction group（n = 16）, and a multiple cerebral infarction group（n = 26） according to their magnetic resonance imaging results. All patients received Tongguan Liqiao acupuncture for 28 days. The main acupoints were Neiguan（PC6）, Renzhong（DU26）, Sanyinjiao（SP6）, Fengchi（GB20）, Wangu（GB12）, and Yifeng（SJ17）. Furthermore, the posterior pharyngeal wall was pricked. Before and after treatment, patient swallowing functions were evaluated with the Kubota Water Test, Fujishima Ichiro Rating Scale, and the Standard Swallowing Assessment. The Barthel Index was also used to evaluate their quality of life. Results showed that after 28 days of treatment, scores on the Kubota Water Test and Standard Swallowing Assessment had decreased, but scores on the Fujishima Ichiro Rating Scale and Barthel Index had increased in each group. The total efficacy rate was 92.2% after treatment, and was most obvious in patients with medulla oblongata infarction（95.9%）. These findings suggest that Tongguan Liqiao acupuncture therapy can repair the connection of upper motor neurons to the medulla oblongata motor nucleus, promote the recovery of brainstem infarction, and improve patient＇s swallowing ability and quality of life.

According to the latest research of ecosystem service（ ES）,the background and connotation of ecosystem services were briefly summarized,the relationship among human activity,climate change,and biodiversity and ecosystem service function（ ESF） was synthetically analyzed,the research trends of ecosystem services function assessment（ ESFA） were discussed from multi-scale,and the perspectives was given based on the past studies. The ecological long-term location monitoring method based on the ESFA should be studied,evaluation index of ESFA should be further improved,and the ESF research on the arid region should be reinforced.

Under the background of setting up a complete system of ecosystem civilization and ecosystem assessment indicators, which were put forward by the party central committee, ecosystem service assessment has become a research hotspot of ecological economics, and played an important role in the ecosystem civilization construction process. On the basis of overviews of the connotations and development histories of ecosystem service and ecological civilization, we analyzed the role of ecosystem service assessment in the ecological civilization construction process from ecological sustainability, human welfare and poverty reduction, which would provide a reference for further research.

目的 探讨特发性震颤（ET）患者认知功能障碍的特点及其影响因素。方法 选取西安交通大学第一附属医院神经内科确诊的ET患者及年龄、性别及受教育程度匹配的健康志愿者作为研究对象,进行一般人口学资料登记、震颤部分评分,采用简明精神状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）、日常生活能力量表（ADL）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）测评。结果 最后纳入88例ET和匹配的63例健康志愿者,MMSE提示31.82%的ET患者具有认知功能障碍,其中定向力、短程记忆、计算力、语言能力、复述、阅读理解、三级命令及画图得分显著低于健康志愿者（P〈0.01）,定向力的损害最严重（K=0.624,S=0.726）,三级命令损伤相对较小（K=0.274,S=0.319）;MoCA测评结果显示,86.36%的ET患者认知功能障碍明显高于健康志愿者（P〈0.05）,其中ET患者的视空间与执行力、画钟、命名、注意力、“100-7”、语言能力、抽象思维、记忆力及定向力得分显著低于健康志愿者（P〈0.01）,视空间与执行能力的损害最严重（K=0.651,S=0.786,P〈0.01）,对“100-7”损伤相对较小（K=0.406,S=0.484,P〈0.01）。年龄、受教育程度对ET患者认知功能障碍有影响（P〈0.05）,ADL分数与认知功能呈负相关（相关系数为-0.375和-0.383,P〈0.001）,当去除焦虑抑郁影响后,起病年龄、震颤分级与认知功能障碍具有相关性（P〈0.05）,将上述影响因素代入二元Logistic回归模型,发现受教育程度对模型具有贡献（P〈0.05）。结论 ET患者存在广泛认知障碍;年龄、受教育程度、日常生活能力障碍、起病年龄和震颤程度分级对认知功能障碍具有影响。

目的探讨认知行为治疗（CBT）联合小剂量利培酮对精神分裂症患者认知功能影响的神经心理学评估.方法采用随机数字表法将100例符合《中国精神障碍分类与诊断标准（第3版）》（CCMD-3）精神分裂症诊断标准的患者分为药物治疗组（对照组）与CBT干预组（研究组）各50例,对照组予以利培酮片治疗,研究组予以CBT干预的同时给予对照组药物剂量的1/3治疗,分别于入组时、治疗6个月及随访6个月采用Wisconsin卡片分类测验（WCST）、听觉注意测验（AAT）、临床记忆量表（CMS）进行认知功能的神经心理学评估.结果治疗6个月后及随访6个月除正确反应数外两组的WCST、AAT、CMS指标与治疗前比较差异有统计学意义（P〈0.05或0.01）;随访6个月时两组WCST总测验数、AAT测验比较差异有统计学意义（P〈0.05）.结论CBT联合小剂量利培酮对精神分裂症患者认知功能障碍改善的持续性和远期疗效可能优于单用利培酮治疗.

目標：本研究主要了解身心障礙鑑定評估兩階段工具，「身心障礙鑑定功能量表」與「福利與服務需求評估訪談表」的關聯性與差異性，並討論對身心障礙者評估結果的影響。方法：運用衛生福利部身心障礙功能鑑定資料庫與需求評估資料庫2015年至2019年的有效資料共59,787筆，針對兩份工具的評估結果運用等級相關、卡方適合度考驗與單因子變異數分析進行比對。結果：根據各項數據，兩份工具是同一個ICF理念但各自表述；身障者社會參與環境因素在整體鑑定過程中難以評量；身障者的障礙認定有受到區域性的差異對待。結論：制度規劃應整合鑑定評估流程、加強環境因素的考量與應用、強化以身障者為核心的互動和參與。整體鑑定評估流程呈現分立式、區隔化、差異性的特徵，影響身障者評估權益。

R697.32