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Shenqi Wuweizi tablet is a Chinese medicine preparation mainly composed of Codonopsis pilosula, Astragalus membranaceus, Kadsura longipedunculata and Ziziphus jujube with many curative effects. The maximum tolerance dose of Shenqi Wuweizi tablet in mice was studied, and its acute toxicity in mice was ex- plored. The results showed that Shenqi Wuweizi tablet did not cause the death of mice at the maximum dosage and mice did not show toxic reaction, so it could be used in livestock production and clinical veterinary treatment. The study provided a theoretical basis for application of Shenqi Wuweizi tablet in livestock production and clinical veterinary medication safety.

[ Objective] A histological study was conducted to investigate the toxicity of ＂Baikening＂ and the toxic effect of ＂Baikening＂ on roosters after longer- term administration at different dose levels. [ Method] Thirty 21-day-old Hy-Line Brown roosters were administered with 0.5 and 1.0 ml of ＂Balkening＂ aqueous extract through drinking water once a day for continuous 14 d. Roosters in control group and experimental groups after drug administration for 14 d and drug with- dmwal for 7 d were euthatfized; livers, kidneys, thymuses, spleens and bursas of Fabricius were collected and weighed for comparative analysis. Various tissues were prepared into paraffin-embedded slices and stained by H. E. , to observe histological changes of various organs under an optical microscope. [ Result ] After drug administration for 14 d, all the roosters in experimental groups survived; there was no visible pathological change in various organs of Hy-Line Brown roosters in each group; organ weights of Fly-Line Brown roosters in various groups showed no significant difference; observation results of tissue slices indicated that there was no pathological change in fine structures, nuclei and cytoplasm of various organs of Hy-Line Brown roosters in different groups ; various blood vessels in different organs also presented no change in blood circulation or other pathological changes. [ Conclusion] ＂Baikening＂ aqueous extract （oral administration） has no toxic and side effect on roosters in the subacute toxicity experiment.