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目的：观察隔药灸、温和灸、电针对克罗恩病（Crohn＇s Disease,CD）大鼠结肠碱性成纤维细胞生长因子（Basic Fibroblast Growth Factor,bFGF）、Ⅰ型胶原,（Collagen Type Ⅰ,Coll）表达的调控作用,探讨针灸治疗克罗恩病肠壁纤维化的作用机制.方法：采用TNBS多次致炎方法制备大鼠克罗恩病模型.将大鼠随机分为正常组、模型组、温和灸组、电针组和隔药灸组.各针灸治疗组选取天枢、气海穴分别采用不同的针灸方法进行治疗.采用免疫组织化学法观察大鼠结肠组织Coll、bFGF蛋白的分布和表达.结果：模型组大鼠结肠组织Col Ⅰ、bFGF蛋白表达显著增强（与正常组相比,P〈0.01）;经过隔药灸、温和灸、电针治疗后,CD大鼠Col Ⅰ、bFGF蛋白表达明显减少（P〈0.01）.结肠组织bFGF与Col Ⅰ蛋白Spearman等级相关分析结果表明,两者具有明显相关性（P〈0.01）.结论：针灸可以下调CD大鼠结肠异常增高的Col Ⅰ、bFGF蛋白表达.bFGF、Col Ⅰ蛋白参与了大鼠CD肠纤维化过程,针灸可能通过降低结肠bFGF蛋白表达,从而调节Col Ⅰ蛋白的沉积而发挥对CD肠纤维化的治疗作用.

目的：观察针刺配合艾灸次髎穴对寒湿凝滞型原发性痛经（primary dysmenorrhea,PD）的临床疗效。方法：将58例寒湿凝滞型P D患者随机分为观察组和对照组,每组29例,观察组采用针刺加悬灸次髎穴,对照组仅用常规针刺。两组均治疗3个疗程后评价疗效。结果：治疗后,两组症状评分均较治疗前降低,差异有统计学意义（P〈0.05）;两组在临床疗效和症状评分上均无显著差异（P〉0.05）。结论：针灸次髎穴对寒湿凝滞型P D疗效显著,与常规针刺治疗的疗效无明显差异,但具有取穴少,患者痛苦小的优点。

Objective： To evaluate investigations of intestinal fibrosis of IBD treated by acupuncture and moxibustion and to analyze the current research situation of intestinal fibrosis. Methods： All reported studies were indexed about intestinal fibrosis of IBD treated by acupuncture and moxibustion and summarized the therapeutic effects of acupuncture and moxibustion on intestinal fibrosis. Results： Ten studies were included in this review, the research results indicated that acupuncture and moxibustion had beneficial effects not only on cytokines and colonic fibroblast but on collagen related to intestinal fibrosis. The expressions of TGF-beta and its mRNA were down regulated, and the expressions of IGF-1, IGF-1R and IGFBP-5 were decreased by acupuncture and moxibustion. The proliferative index of CBF was prohibited and the expression of type Ⅰ, Ⅲ, Ⅳ collagen was degraded by this therapy. Conclusion： Acupuncture and moxibustion can prevent and improve the colonic tissue fibrosis of IBD in some extent, but many research settings and methods should be improved to lucubrate the real therapeutic effects and the effective mechanism of acupuncture and moxibustion.

Tongguan Liqiao acupuncture therapy has been shown to effectively treat dysphagia after stroke-based pseudobulbar paralysis. We presumed that this therapy would be effective for dysphagia after bulbar paralysis in patients with brainstem infarction. Sixty-four patients with dysphagia following brainstem infarction were recruited and divided into a medulla oblongata infarction group（n = 22）, a midbrain and pons infarction group（n = 16）, and a multiple cerebral infarction group（n = 26） according to their magnetic resonance imaging results. All patients received Tongguan Liqiao acupuncture for 28 days. The main acupoints were Neiguan（PC6）, Renzhong（DU26）, Sanyinjiao（SP6）, Fengchi（GB20）, Wangu（GB12）, and Yifeng（SJ17）. Furthermore, the posterior pharyngeal wall was pricked. Before and after treatment, patient swallowing functions were evaluated with the Kubota Water Test, Fujishima Ichiro Rating Scale, and the Standard Swallowing Assessment. The Barthel Index was also used to evaluate their quality of life. Results showed that after 28 days of treatment, scores on the Kubota Water Test and Standard Swallowing Assessment had decreased, but scores on the Fujishima Ichiro Rating Scale and Barthel Index had increased in each group. The total efficacy rate was 92.2% after treatment, and was most obvious in patients with medulla oblongata infarction（95.9%）. These findings suggest that Tongguan Liqiao acupuncture therapy can repair the connection of upper motor neurons to the medulla oblongata motor nucleus, promote the recovery of brainstem infarction, and improve patient＇s swallowing ability and quality of life.

目的：比较薄棉灸配合围刺与西药治疗带状疱疹（herpes zoster,HZ）的临床疗效差异。方法：将83例带状疱疹患者按入院先后顺序分为2组，薄棉灸组41例，西药组42例。薄棉灸组给予疱疹表面薄棉灸，辅以疱疹周围围刺；台疗，每日治疗1次。西药组给予静脉滴注阿昔洛韦，每次O．25g，每日1次；阿昔洛韦软膏涂擦患处每日3-5次。治疗10d后，比较两组患者水疱开始吸收时间、结痂时间、疼痛减轻时间、显效时间、皮损愈合时间及后遗神经痛发生率。结果：治疗过程中，薄棉灸组脱落1例，西药组脱落2例。薄棉灸组愈显率为92．5％，总有效率为97．5％；西药组愈显率为72．5％，总有效率87．5％，两组愈显率及总有效率差异均有统计学意义（P〈0．05）。薄棉灸组患者疱疹开始吸收时间、结痂时间、疼痛减轻时间、显效时间、皮损愈合时间均明显低于西药组（P〈0．05）。薄棉灸组后遗神经痛发生率为2．07％，显著低于西药组的9．19％（P〈0．01）。结论：薄棉灸配合围刺治疗Hz疗效优于阿昔洛韦，且能明显降低后遗神经痛的发生率。