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目的观察参附益肾胶囊治疗高海拔地区阳虚血瘀型糖尿病性肾病的临床疗效。方法将53例患者随机分为2组,治疗组31例,对照组22例。对照组西医常规治疗;治疗组在对照组基础上给予参附益肾胶囊,观察两组的临床疗效及患者血生化改变情况,如血肌酐（creatinine,SCr）、谷氨酸转氨酶（alanine aminotransferase,ALT）、血尿酸（uric acid,UA）、尿微量蛋白（urinary microalbumin,MALB）、肾小球滤过率（glomerular filtration rate,GFR）等指标。结果治疗组总有效率90.32%,对照组81.82%,两组比较,有显著性差异（P〈0.05）。两组治疗后主要症状均有不同程度改善,与治疗前比较,有显著性差异（P〈0.05）。治疗组治疗前后ALT无差异,治疗前后两组的CR、UA、MALB、GFR有差异,且治疗组改善更为显著,与对照组比较,有显著性差异（P〈0.05）。结论参附益肾胶囊具有改善主要临床症状,降低糖尿病肾病患者CR、GFR、UA、MALB水平,从而保护肾功能,延缓糖尿病性肾病进程的作用。

The Taklimakan Desert（TD） and Gobi Desert（GD） are two of the most important dust sources in East Asia, and have important impact on energy budgets, ecosystems and water cycles at regional and even global scales. To investigate the contribution of the TD and the GD to dust concentrations in East Asia as a whole, dust emissions, transport, and deposition over the TD and the GD in different seasons from 2007 to 2011 were systematically compared, based on the Weather Research and Forecasting model coupled with Chemistry（WRF-Chem）. Dust emissions, uplift, and long-range transport related to these two dust source regions were markedly different due to differences in topography, elevation, thermal conditions, and atmospheric circulation. Specifically,the topography of the GD is relatively flat, and at a high elevation, and the area is under the influence of two jet streams at high altitudes, resulting in high wind speeds in the upper atmosphere. Deep convective mixing enables the descending branch of jet streams to continuously transport momentum downward to the mid-troposphere, leading to enhanced wind speeds in the lower troposphere over the GD which favors the vertical uplift of the GD dust particles. Therefore, the GD dust was very likely to be transported under the effect of strong westerly jets, and thus played the most important role in contributing to dust concentrations in East Asia. Approximately 35% and 31% of dust emitted from the GD transported to remote areas in East Asia in spring and summer, respectively. The TD has the highest dust emission capabilities in East Asia, with emissions of about 70.54 Tg yr.1 in spring, accounting for 42% of the total dust emissions in East Asia. However, the TD is located in the Tarim Basin and surrounded by mountains on three sides. Furthermore, the dominant surface wind direction is eastward and the average wind speed at high altitudes is relatively small over the TD. As a result, the TD dust particles are not easily transported outside the Tarim Basin, such that most of the dust particles are re-deposited after uplift, at a total deposition rate of about 40 g m.2. It is only when the TD dust particles are uplifted above 4 km, and entrained in westerlies that they begin to undergo a long-range transport. Therefore,the contribution of the TD dust to East Asian dust concentrations was relatively small. Only 25% and 23% of the TD dust was transported to remote areas over East Asia in spring and summer, respectively.

A total of 12 indices of temperature extremes and 11 indices of precipitation extremes at 111 stations in southwestern China at altitudes of 285-4700 m were examined for the period 1961-2008. Significant correlations of temperature extremes and elevation included the trends of diurnal temperature range, frost days, ice days, cold night frequency and cold day frequency. Regional trends of growing season length, warm night frequency, coldest night and warmest night displayed a statistically significant positive correlation with altitude. These characteristics indicated the obvious warming with altitude. For precipitation extreme indices, only the trends of consecutive dry days, consecutive wet days, wet day precipitation and the number of heavy precipitation days had significant correlations with increasing altitude owing to the complex influence of atmospheric circulation. It also indicated the increased precipitation mainly at higher altitude areas, whereas the increase of extreme precipitation events mainly at lowers altitude. In addition, the clearly local influences are also crucial on climate extremes. The analysis revealed an enhanced sensitivity of climate extremes to elevation in southwestern China in the context of recent warming.

Snow disaster is one of the top ten natural disasters worldwide, and the most se- vere natural disaster to affect the pastoral areas of the Qinghai-Tibet Plateau. Based on the hazard harmfulness data collected from historical records and data collected from entities affected by this hazard in 2010, a comprehensive analysis of the 18 indexes of snow disaster on the Qinghai-Tibet Plateau was conducted, encompassing the hazard harmfulness, the amount of physical exposure the hazard-bearing entities face, the sensitivity to the hazard, and the capacity to respond to the disaster. The analysis indicates that： （1） areas at high-risk of snow disaster on the Qinghai-Tibet Plateau are located in certain areas of the counties of Yecheng and Pishan in the Xinjiang region; （2） areas at medium-risk of snow disaster are found between the Gangdise Mountains and the Himalayas in the central-western part of the Qinghai-Tibet Plateau, and the southeastern part of the southern Qinghai Plateau; （3） the risk of snow disaster is generally low throughout the large area to the south of 30°N and the re- gion on the border of the eastern Qinghai-Tibet Plateau. Overall, the risk of snow disaster in high-altitude areas of the central Qinghai-Tibet Plateau is higher than that at the edge of the plateau.

Characteristics of cloud overlap over Eastern Asia are analyzed using a threeyear dataset （20072009） from the cloud observing satellite CloudSat. Decorrelation depth Lis retrieved, which represents cloud overlap characteristics in the simulation of cloudradiation processes in global climate models. Results show that values of L in six study regions are generally within the range 03 km. By categorizing L according to cloud amount in subregions, peak L appears near subregions with cloud amount between 0.6 and 0.8. Average L is 2.5 km. L at higher altitudes is generally larger than at lower lati tudes. Seasonal variations of L are also clearly demonstrated. The sensitivity of cloud radiative forcing （CRF） to L;y in Community Atmosphere Model 3.0 of the National Center for Atmospheric Research （CAM3/NCAR） is analyzed. The result shows that L can have a big impact on simulation of CRF, especially in major monsoon regions and the MidEastern Pacif ic, where the difference in CRF can reach 4050 W m2. Therefore, accurate parameterization of cloud vertical overlap struc ture is important to CRF simulation and its feedback to climate.

In this study, 39 leaf samples of three angiosperms （Betula albo-sinensis, tree species; and Caragana jubata and Berberis diaphana, shrub species） were collected in the middle-east parts at 2300-3640 m asl of the Qilian Mountains to study the varia- tions of leaf characteristics of angiosperms with altitude change in inland high-altitude regions of China. Five leaf indexes, viz. epidermal cell density （ED）, stomatal density （SD）, stomatal index （SI）, leaf vein density （VD） and carbon isotopic ratio （c~13C） were analyzed in laboratory. The results show that there are significant or even very significant linear correlations between the five indexes and altitude, of which SD, SI and VD exhibit a negative correlation with altitude, while ED and Ot3C exhibit a positive correlation with altitude. Such a correlation assemblage is quite different from the situation in the low-altitude humid environment. Generally, only an assemblage of positive correlations can be observed between the indexes （viz. SD, SI and （~3C, etc.） and the altitude in the low-altitude humid environment, which were caused mainly by the plants＇ responses to the change of atmospheric CO2 concentration （Co）. However, an assemblage of the negative and positive correlations found here may be attributed mainly to the plants＇ responses to the change of physiological drought caused by change of low temperature, and here it is preliminarily called the inland high-altitude pattern of plant leaf variations.

Populations living at high altitudes （HAs）, particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis （16 g dl-1〈haemoglobin （Hb）≤21 gdl-1） and others with excessive erythrocytosis （EE） （Hb〉21 g dl-1）. Elevated haemoglobin values （EE） are associated with chronic mountain sickness, a condition reflecting the lack of adaptation to HA. According to current data, native men from regions of HA are not adequately adapted to live at such altitudes if they have elevated serum testosterone levels. This seems to be due to an increased conversion of dehydroepiandrosterone sulphate （DH EAS） to testosterone. Men with erythrocytosis at HAs show higher serum androstenedione levels and a lower testosterone/androstenedione ratio than men with EE, suggesting reduced 17beta-hydroxysteroid dehydrogenase （17beta-HSD） activity. Lower 17beta-HSD activity via A4-steroid production in men with erythrocytosis at HA may protect against elevated serum testosterone levels, thus preventing EE. The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the A5-pathway. Currently, there are various situations in which people live （human biodiversity） with low or high haemoglobin levels at HA. Antiquity could be an important adaptation component for life at HA, and testosterone seems to participate in this process.

The observed characteristics of lower atmospheric ducts over the South China Sea (SCS) were analyzed based on Global Position Systerm (GPS) radiosonde data collected four times daily during autumn open cruises from 2006 to 2012. Duct occurrence, thickness, and strength over the SCS were about 40%, 150-m thick, and 8 M units, respectively, which were larger than during the summer monsoon period. Most ducts occurred at heights <1 500 m and these ducts easily trap electromagnetic wave clusters with wavelengths <2 m. Diurnal variation of the SCS ducts appeared evident. They occurred more often at midnight at higher altitudes (about 1 100 m), with a thickest layer of about 145 m and less frequently during the evening at lower altitudes (about 800 m), with a thinnest layer of about 125 m. Moreover, ducts during the daytime at a mean height of about 900 m, with the greatest strength of about 10 M units. Furthermore, all duct variables observed over the SCS in autumn decreased from north to south. These findings are useful not only in the design of radar and communication systems, but also for evaluating possible effects of anomalous propagation on meteorological radar and military applications.

Using data from the Cluster spacecraft from January 2003 to December 2004, we perform a statistical study on some properties of the field-aligned electron （FAE） events and interplanetary magnetic field （IMF） By dependence of FAE events with different durations in high-altitude polar regions. A total of 1335 FAE events were observed by the C3 spacecraft. More down-flowing events were observed in the Southern Hemisphere, and more up-flowing events were observed in the Northern Hem- isphere. It proves that down-flowing events mainly originate from magnetosphere or solar wind and up-flowing events are mainly derived from ionosphere. Short-lifetime events showed a morning concentration in the magnetic local time distribution, and long-lifetime events were concentrated both before and after noon. For the IMF By dependence of the FAE events, short-lifetime events were much affected by IMF By and resulted in a morning concentration, while the long-lifetime events were almost unaf- fected by IMF By. With further analysis, we determined that the short-lifetime and long-lifetime events had different sources.

One hundred and ten samples of rainwater were collected for chemical analysis at the summit of Huangshan Mountain, a high-altitude site in East China, from July 2010 to June 2011. The volume-weighted-mean （VWM） pH for the whole sampling period was 5.03. SO2- and Ca2＋ were the most abundant anion and cation, respectively. The ionic concentrations varied monthly with the highest concentrations in winter/spring and the lowest in summer. Evident inter-correlations were found among most ions, indicating the common sources for some species and fully mixing characteristics of the alpine precipitation chemistry. The VWM ratio of [SO]-]/[NO3] was 2.54, suggesting the acidity of rainwater comes from both nitric and sulfuric acids. Compared with contemporary observations at other alpine continental sites in China, the precipitation at Huangshan Mountain was the least polluted, with the lowest ionic concentrations. Trajectories to Huangshan Mountain on rainy days could be classified into six groups. The rainwater with influencing air masses originating in Mongolia was the most polluted with limited effect. The emissions of Jiangxi, Anhui, Zhejiang and Jiangsu provinces had a strong influence on the overall rain chemistry at Huangshan Mountain. The rainwater with influencing air masses from Inner Mongolia was heavily polluted by anthropogenic pollutants.