Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
168
result(s) for
"1794"
Sort by:
The Whiskey Rebellion
\"The fight over taxation wasn't just a part of the American Revolution. It continued after the war was resolved. When the federal government placed a tax on whiskey in 1791, farmers in Pennsylvania, who depended on selling whiskey to make ends meet, were outraged. They took up arms and attacked federal tax collectors. President George Washington used several tactics to quell the insurrection. The full story of the Whiskey Rebellion, as it was called, is recounted in this volume, along with discussion of its repercussions on domestic policy. Young historians will especially appreciate the vivid images of the incident and those involved.\"-- (Source of summary not specified).
Book
Glycan recognition in globally dominant human rotaviruses
Rotaviruses (RVs) cause life-threatening diarrhea in infants and children worldwide. Recent biochemical and epidemiological studies underscore the importance of histo-blood group antigens (HBGA) as both cell attachment and susceptibility factors for the globally dominant P[4], P[6], and P[8] genotypes of human RVs. How these genotypes interact with HBGA is not known. Here, our crystal structures of P[4] and a neonate-specific P[6] VP8*s alone and in complex with H-type I HBGA reveal a unique glycan binding site that is conserved in the globally dominant genotypes and allows for the binding of ABH HBGAs, consistent with their prevalence. Remarkably, the VP8* of P[6] RVs isolated from neonates displays subtle structural changes in this binding site that may restrict its ability to bind branched glycans. This provides a structural basis for the age-restricted tropism of some P[6] RVs as developmentally regulated unbranched glycans are more abundant in the neonatal gut.
Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu
et al
. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.
Journal Article
The fall of Robespierre : 24 hours in revolutionary Paris
The day of 9 Thermidor (27 July 1794) is universally acknowledged as a major turning-point in the history of the French Revolution. At 12 midnight, Maximilien Robespierre, the most prominent member of the Committee of Public Safety which had for more than a year directed the Reign of Terror, was planning to destroy one of the most dangerous plots that the Revolution had faced. By 12 midnight at the close of the day, following a day of uncertainty, surprises, upsets and reverses, his world had been turned upside down. He was an outlaw, on the run, and himself wanted for conspiracy against the Republic. He felt that his whole life and his Revolutionary career were drawing to an end. As indeed they were. He shot himself shortly afterwards. Half-dead, the guillotine finished him off in grisly fashion the next day. 'The Fall of Robespierre' provides an hour-by-hour analysis of these 24 hours.
Book
Untold. Whiskey Rebellion
Whiskey fanned the flames of a Pennsylvanian tax uprising that lasted for three years!
Streaming Video
Rotavirus infection
Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system. In addition, rotavirus infections can lead to antigenaemia (which is associated with more severe manifestations of acute gastroenteritis) and viraemia, and rotavirus can replicate in systemic sites, although this is limited. Reinfections with rotavirus are common throughout life, although the disease severity is reduced with repeat infections. The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific immunoglobulin A has a role in both aspects. The management of rotavirus infection focuses on the prevention and treatment of dehydration, although the use of antiviral and anti-emetic drugs can be indicated in some cases.
Rotaviruses are double-stranded RNA viruses that are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. This Primer gives an overview of the pathophysiology of rotavirus infection and describes how the introduction of vaccinations has altered the epidemiology and demographics of this disease.
Journal Article
Robespierre and the Festival of the Supreme Being : The search for a republican morality
The search for a republican morality provides an exciting new study of an important event in the French Revolution and a defining moment in the career of its principal actor, Maximilien Robespierre, the Festival of the Supreme Being. This day of national celebration was held to inaugurate the new state religion, the Cult of the Supreme Being, and whilst traditionally it has been dismissed as a compulsory political event, this book redefines its importance as a hugely popular national event. Hitherto unused or disregarded source material is used to offer new perspective to the national reaction to Robespierre's creation of the Festival and of his search for a new republican morality. It is the first ever detailed study in English of this area of French Revolutionary history, the first in any language since 1988 and will be welcomed by scholars and students of this period.
Book
Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection
Neonatal rotavirus infections are predominantly asymptomatic. While an association with gastrointestinal symptoms has been described in some settings, factors influencing differences in clinical presentation are not well understood. Using multidisciplinary approaches, we show that a complex interplay between human milk oligosaccharides (HMOs), milk microbiome, and infant gut microbiome impacts neonatal rotavirus infections. Validating in vitro studies where HMOs are not decoy receptors for neonatal strain G10P[11], population studies show significantly higher levels of Lacto-N-tetraose (LNT), 2’-fucosyllactose (2’FL), and 6’-siallylactose (6’SL) in milk from mothers of rotavirus-positive neonates with gastrointestinal symptoms. Further, these HMOs correlate with abundance of
Enterobacter
/
Klebsiella
in maternal milk and infant stool. Specific HMOs also improve the infectivity of a neonatal strain-derived rotavirus vaccine. This study provides molecular and translational insight into host factors influencing neonatal rotavirus infections and identifies maternal components that could promote the performance of live, attenuated rotavirus vaccines.
Neonatal rotavirus infections are associated with gastrointestinal symptoms in some settings, but the role of host factors in clinical presentation is unclear. Here, Ramani et al. show that human milk oligosaccharides and microbiome are associated with symptomatic infection with neonatal strain G10P[11].
Journal Article
The Whiskey Rebellion
Recapturing the historical drama and significance of the Whiskey Rebellion--the first large-scale resistance to a law of the U.S. government under the Constitution--Slaughter assesses this tax rebellion among frontier farmers in 1794 in relation to interregional tensions, republican ideology, and the social and political conflict of the 1780s and '90s.
eBook