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Lanford Wilson : early stories, sketches, and poems
Before Lanford Wilson became a Pulitzer Prize-winning playwright, with such celebrated productions as The Hot 1 Baltimore, Fifth of July, Talley's Folly, and Burn This, he wrote dozens of short stories and poems, many of which take place in the 1950s small-town Missouri where he grew up. This selection of Wilson's early work, written between 1955 and 1964 when he was between the ages of 18 and 27, provides a rare look at a young writer developing his style. The stories explore many of the themes Wilson later took up in the theatre, such as sexual identity and the rupture of societies and families. These never-before-published works - part of the manuscript collection donated by Wilson to the University of Missouri - shed light on the roots of some of America's best-loved plays and are accomplished and evocative works in their own right. -- from dust jacket.
Book
Creutzfeldt–Jakob disease and other prion diseases (Primer)
Prion diseases share common clinical and pathological characteristics such as spongiform neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed prion protein. The characteristic features of prion diseases are long incubation times, short clinical courses, extreme resistance of the transmissible agent to degradation and lack of nucleic acid involvement. Sporadic and genetic forms of prion diseases occur worldwide, of which genetic forms are associated with mutations in PRNP. Human to human transmission of these diseases has occurred due to iatrogenic exposure, and zoonotic forms of prion diseases are linked to bovine disease. Significant progress has been made in the diagnosis of these disorders. Clinical tools for diagnosis comprise brain imaging and cerebrospinal fluid tests. Aggregation assays for detection of the abnormally folded prion protein have a clear potential to diagnose the disease in peripherally accessible biofluids. After decades of therapeutic nihilism, new treatment strategies and clinical trials are on the horizon. Although prion diseases are relatively rare disorders, understanding their pathogenesis and mechanisms of prion protein misfolding has significantly enhanced the field in research of neurodegenerative diseases.This Primer by Zerr et al. discusses the epidemiology, pathophysiology, diagnosis and potential future treatments for Creutzfeldt–Jakob disease and other human prion diseases.
Journal Article
Queer Politics and Sexual Modernity in Taiwan
This book analyses the critical reception of Pai Hsien-yung’s Crystal Boys, one of Taiwan’s first recognized gay novels, and one which has played an important role in redefining sexual modernity and linking this to ongoing cultural dialogues on state building. It examines the deployment of sexuality over the past five decades in Taiwan by paying particular attention to male homosexuality and prostitution. In addition to literary and film material, the study engages a number of relevant legal cases and media reports. Through Hans Huang’s primary research and historical investigations, the book not only illuminates the construction of gendered sexual identities in Taiwanese culture but also, in a reflexive fashion, critiques the culture that produces them.
eBook
The music in George's head : George Gershwin creates Rhapsody in blue
\"With rhythmic swirls of words and pictures, Suzanne Slade and Stacy Innerst [introduce George Gershwin's life and] ... reveal just how ... [he] reached inside his head to create his masterpiece, Rhapsody in blue\"--Dust jacket flap.
BOOK
Rapidly progressive dementias — aetiologies, diagnosis and management
Rapidly progressive dementias (RPDs) are a group of heterogeneous disorders that include immune-mediated, infectious and metabolic encephalopathies, as well as prion diseases and atypically rapid presentations of more common neurodegenerative diseases. Some of these conditions are treatable, and some must be diagnosed promptly because of their potential infectivity. Prion disease is considered to be the prototypical RPD, but over the past two decades, epidemiological reports and the identification of various encephalitis-mediating antibodies have led to a growing recognition of other encephalopathies as potential causes of rapid cognitive decline. Knowledge of RPD aetiologies, syndromes and diagnostic work-up protocols will help clinicians to establish an early, accurate diagnosis, thereby reducing morbidity and mortality, especially in immune-mediated and other potentially reversible dementias. In this Review, we define the syndrome of RPD and shed light on its different aetiologies and on secondary factors that might contribute to rapid cognitive decline. We describe an extended diagnostic procedure in the context of important differential diagnoses, discuss the utility of biomarkers and summarize potential treatment options. In addition, we discuss treatment options such as high-dose steroid therapy in the context of therapy and diagnosis in clinically ambiguous cases.The term ‘rapidly progressive dementia’ (RPD) describes a cognitive disorder with fast progression, leading to dementia within a relatively short time. This Review discusses the wide range of RPD aetiologies, as well as the diagnostic approach and treatment options.
Journal Article
مذابح نانجينغ : أول سجل وثائقي كامل لمؤلف صيني حول \مذابح نانجينغ\
مذابح نانجينغ، تلك الجريمة الأكثر قسوة وبشاعة في العصر الحديث، إبادة كاملة لأكثر من ثلاثمائة ألف من الجنود والمدنيين الصينيين العزل على يد جيش الاحتلال الياباني في النصف الأول من القرن العشرين، تلقي بظلالها على تاريخ العلاقات الصينية اليابانية منذ ارتكاب المذبحة في الثالث عشر من ديسمبر 1937، وحتى يومنا هذا. وهذا الكتاب بجزأيه الأول والثاني، هو أول سجل وثائقي كامل لمؤلف صيني، وهو نائب رئيس اتحاد كتاب الصين، حول مذابح نانجينغ. حيث لم تشهد حركة الكتابة والتأريخ خلال العقود الماضية مؤلفا توثيقيا شاملا كالذي بين أيدينا الآن.
BOOK
They were in Nanjing
The Nanjing Massacre, which took place after the Japanese attacked and captured Nanjing in December 1937, shocked the world with the magnitude of its atrocities. With newly uncovered eye-witness material left behind by American and British journalists, mi
eBook
Forgotten ally : China's World War II, 1937-1945
\"For decades, a major piece of World War II history has gone virtually unwritten. China was the fourth great ally, partner to the United States, the Soviet Union, and Great Britain, yet its drama of invasion, resistance, slaughter, and political intrigue remains little known in the West. In this emotionally gripping book, made possible through access to newly unsealed Chinese archives, Rana Mitter unfurls the story of China's World War II as never before and rewrites the larger history of the war in the process. He focuses his narrative on three towering leaders -- Chiang Kai-shek, Mao Zedong, and the lesser-known collaborator Wang Jingwei -- and extends the timeline of the war back to 1937, when Japanese and Chinese troops began to clash, fully two years before Hitler invaded Poland. Unparalleled in its research and scope, Forgotten Ally is a sweeping, character-driven history that will be essential reading not only for anyone with an interest in World War II, but also for those seeking to understand today's China, where, as Mitter reveals, the echoes of the war still reverberate\"-- Provided by publisher.
Book
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Through injection of human Alzheimer's disease (AD) brain extracts containing pathological tau protein into transgenic mouse lines harboring different levels of amyloid plaque burden, the authors find that the presence of amyloid plaques modifies endogenous pools of tau protein, creating a unique environment required for the seeding and spreading of distinct tau pathologies.
Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pathological tau (AD-tau) into Aβ plaque–bearing mouse models that do not overexpress tau, we recapitulated the formation of three major types of AD-relevant tau pathologies: tau aggregates in dystrophic neurites surrounding Aβ plaques (NP tau), AD-like neurofibrillary tangles (NFTs) and neuropil threads (NTs). These distinct tau pathologies have different temporal onsets and functional consequences on neural activity and behavior. Notably, we found that Aβ plaques created a unique environment that facilitated the rapid amplification of proteopathic AD-tau seeds into large tau aggregates, initially appearing as NP tau, which was followed by the formation and spread of NFTs and NTs, likely through secondary seeding events. Our study provides insights into a new multistep mechanism underlying Aβ plaque–associated tau pathogenesis.
Journal Article