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The flame : poems, notebooks, lyrics, drawings
A collection of lyrics, poems, notebook sketches, and self-portraits maps the Rock and Roll Hall of Fame inductee's singular creative journey through the weeks just prior to his death.
Book
Ali on Ali : why he said what he said when he said it
\"\"Muhammad Ali was a champion, a poet, a prophet. Sports Illustrated called him \"the greatest athlete of the twentieth century.\" And yet he was even more than all of that, \"a whole greater than the sum of its parts . . . bigger, brighter, more original and influential than just about anyone of his era\" (Barack Obama). He got there with his fists, with his actions, and above all, with his words. Compiled and written by his daughter Hana Ali, with sportswriter Danny Peary, Ali on Ali brings together a remarkable mix of Ali's 70 most humorous, poignant, inspirational, political, and philosophical quotes, all with their origins. Here's Ali's enduring boast, \"I am the greatest!\"--and how it was inspired by professional wrestler Gorgeous George. The story behind one of the most memorably poetic lines of the century--\"Float like a butterfly, sting like a bee.\" The heard-round-the-world defiance of \"I ain't got no quarrel with them Viet Cong,\" and its moving context. And the stories behind quotes ranging from outrage--\"We been in jail for 400 years,\" to inspiration--\"I hated every minute of training, but I said 'Don't quit. Suffer now and live the rest of your life as a champion,'\" to that infectious combination of humor and bravado--\"If you even dream of beating me you better wake up and apologize.\" Included are powerful photographs throughout, from iconic fight scenes to never-before-seen Ali family snapshots; quotes about Ali, from Martin Luther King Jr. to Billy Crystal; a career timeline; and a personal introduction by Hana Ali\"-- Provided by publisher.
BOOK
Iris from the ground up: A modular foundation for higher-order concurrent separation logic
Iris is a framework for higher-order concurrent separation logic, which has been implemented in the Coq proof assistant and deployed very effectively in a wide variety of verification projects. Iris was designed with the express goal of simplifying and consolidating the foundations of modern separation logics, but it has evolved over time, and the design and semantic foundations of Iris itself have yet to be fully written down and explained together properly in one place. Here, we attempt to fill this gap, presenting a reasonably complete picture of the latest version of Iris (version 3.1), from first principles and in one coherent narrative.
Journal Article
Doubling the Accuracy of Indoor Positioning: Frequency Diversity
Determination of indoor position based on fine time measurement (FTM) of the round trip time (RTT) of a signal between an initiator (smartphone) and a responder (Wi-Fi access point) enables a number of applications. However, the accuracy currently attainable—standard deviations of 1–2 m in distance measurement under favorable circumstances—limits the range of possible applications. An emergency worker, for example, may not be able to unequivocally determine on which floor someone in need of help is in a multi-story building. The error in position depends on several factors, including the bandwidth of the RF signal, delay of the signal due to the high relative permittivity of construction materials, and the geometry-dependent “noise gain” of position determination. Errors in distance measurements have unusal properties that are exposed here. Improvements in accuracy depend on understanding all of these error sources. This paper introduces “frequency diversity,” a method for doubling the accuracy of indoor position determination using weighted averages of measurements with uncorrelated errors obtained in different channels. The properties of this method are verified experimentally with a range of responders. Finally, different ways of using the distance measurements to determine indoor position are discussed and the Bayesian grid update method shown to be more useful than others, given the non-Gaussian nature of the measurement errors.
Journal Article
Muhammad Ali unfiltered
THE FIGHTER. THE ACTIVIST. THE MAN. THE ICON. An officially authorized collection, Muhammad Ali Unfiltered is Jeter Publishing's intimate look at one of the most inspiring figures of our age. Celebrate the life of Muhammad Ali in these 200-plus pages of images, quotes, and tributes to the Greatest of All Time.
BOOK
Keep quiet: the HUSH complex in transcriptional silencing and disease
The human silencing hub (HUSH) complex is an epigenetic repressor complex whose role has emerged as an important guardian of genome integrity. It protects the genome from exogenous DNA invasion and regulates endogenous retroelements by recruiting histone methyltransferases catalyzing histone 3 lysine 9 trimethylation (H3K9me3) and additional proteins involved in chromatin compaction. In particular, its regulation of transcriptionally active LINE1 retroelements, by binding to and neutralizing LINE1 transcripts, has been well characterized. HUSH is required for mouse embryogenesis and is associated with disease, in particular cancer. Here we provide insights into the structural and biochemical features of the HUSH complex. Furthermore, we discuss the molecular mechanisms by which the HUSH complex is recruited to specific genomic regions and how it silences transcription. Finally, we discuss the role of HUSH complex members in mammalian development, antiretroviral immunity, and diseases such as cancer.
Here, the authors discuss the various roles of the HUSH transcriptional silencing complex and its dysregulation in disease.
Journal Article
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it ensures their transcriptional silencing. The histone methyltransferases (HMTs) that methylate H3K9 — in mammals Suppressor of variegation 3–9 homologue 1 (SUV39H1), SUV39H2, SET domain bifurcated 1 (SETDB1), SETDB2, G9A and G9A-like protein (GLP) — and the ‘readers’ of H3K9me2 or H3K9me3 are highly conserved and show considerable redundancy. Despite their redundancy, genetic ablation or mistargeting of an individual H3K9 methyltransferase can correlate with impaired cell differentiation, loss of tissue identity, premature aging and/or cancer. In this Review, we discuss recent advances in understanding the roles of the known H3K9-specific HMTs in ensuring transcriptional homeostasis during tissue differentiation in mammals. We examine the effects of H3K9-methylation-dependent gene repression in haematopoiesis, muscle differentiation and neurogenesis in mammals, and compare them with mechanistic insights obtained from the study of model organisms, notably Caenorhabditis elegans and Drosophila melanogaster. In all these organisms, H3K9-specific HMTs have both unique and redundant roles that ensure the maintenance of tissue integrity by restricting the binding of transcription factors to lineage-specific promoters and enhancer elements.Histone H3 Lys9 (H3K9)-methylated heterochromatin ensures transcriptional silencing of repetitive elements and genes, and its deregulation leads to impaired cell and tissue identity, premature aging and cancer. Recent studies in mammals clarified the roles H3K9-specific histone methyltransferases in ensuring transcriptional homeostasis during tissue differentiation.
Journal Article