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The summer house : a novel
\"Flossy Merrill has managed to--somewhat begrudgingly--gather her three ungrateful grown children from their dysfunctional lives for a summer reunion at the family's Rhode Island beach house ... With her family finally congregated under one seaside roof, Flossy is determined to steer her family back on course even as she prepares to reveal the fate of the summer house that everyone has thus far taken for granted: she's selling it. The Merrill children are both shocked and outraged and each returns to memories of their childhoods at their once beloved summer house--the house where they have not only grown up, but from which they have grown away\"-- Provided by publisher.
Book
Recruitment of mid‐life adults to a randomized clinical trial: The multicultural healthy diet study to reduce cognitive decline and Alzheimer's disease risk
INTRODUCTION Poor representation of racial/ethnic minority groups limits the validity and generalizability of clinical trials and contributes to inequities in medicine and science. OBJECTIVES To recruit a multicultural sample of mid‐life individuals using multiple recruitment modalities for a randomized controlled trial of diet and cognition comparing an anti‐inflammatory dietary intervention versus usual diet and the effect on cognition. METHODS This study describes the utility of various modalities to recruit a multi‐cultural cohort. Recruitment techniques, the success rate of each, and characteristics of participants are compared to representative Bronx U.S. Census statistics. Participants were identified in target communities using voter registration rolls paired with marketing lists and enriched patient lists extracted from electronic health records of mid‐life (40–65 years) adults in Bronx, New York. Outreach activities, including print and social media, supplemented these lists to promote the study. RESULTS Over 4 years of recruitment, invitation letters, followed by telephone calls, yielded the highest number of randomized recruits, with 80.5% of participants recruited prior to the pandemic and 90.1% during the pandemic. A total of 290 participants enrolled in proportion to the racial/ethnic breakdown of targeted Bronx communities. However, women were overrepresented compared to the overall Bronx population. Each recruitment modality had strengths and weaknesses. The combination resulted in reaching an important sector of the population that could benefit from interventions. Voter registration lists reached a broad spectrum of targeted communities and resulted in enrollment and randomization of the majority of participants. Online registries (e.g., ResearchMatch) and outreach activities yielded efficient enrollment. DISCUSSION Our multi‐pronged strategy led to successful enrollment of a multi‐cultural sample. Although the systematic list approach was the most productive, the importance of reaching out to community was crucial. Refining techniques of online registries, working with trusted community organizations, continuous assessment, and experimentation with other modalities may be helpful. Highlights ADRD affects US minority populations disproportionately. Multiple recruitment methods help engage the underrepresented in clinical trials. Use of voter registration and EHR lists allow recruiters to reach a wide and heterogenous audience. Letters followed by personal phone calls are effective in recruitment. Outreach to the community provides a person‐to‐person connection to the study
Journal Article
Bad business
Lindy gets a surprise windfall that allows her to pay for her dream trip to the Arctic. The only problem is, the windfall is a mistake made by a confused old lady. Lindy knows that keeping the money is wrong, yet she does it anyway. But when she tells a schoolmate what she has done, she really starts paying for her bad deed.
Book
After the baby boomers
Much has been written about the profound impact the post-World War II baby boomers had on American religion. But the lifestyles and beliefs of the generation that has followed--and the influence these younger Americans in their twenties and thirties are having on the face of religion--are not so well understood. It is this next wave of post-boomers that Robert Wuthnow examines in this illuminating book.
eBook
Pretty little liars
About four best friends and the secrets they are trying to hide from each other, this is the first in a series of four books. Aria, Emily, Spencer, Hanna and Alison have been best friends since the third grade. They go everywhere together and think no one can come between them.
BOOK
Age-related reduction of BOLD modulation to cognitive difficulty predicts poorer task accuracy and poorer fluid reasoning ability
Aging is associated with reduced resources needed to perform difficult cognitive tasks, but the neural underpinnings are not well understood, especially as there is scant evidence linking functional brain differences to aging cognition. Therefore, the current study examined modulation of fMRI activation from easier to harder spatial distance judgments across a large lifespan sample (N=161; ages 20–94) to identify when in the lifespan modulation to difficulty begins to show deficits and if age-related modulation predicts cognition. Analyses revealed two sets of regions in which modulation increased with difficulty due to either more activation (positive modulation) or more deactivation (negative modulation) to difficulty. These two networks evidenced differential aging trajectories: a right-lateralized fronto-parietal network that decreased in modulation to difficulty between middle- and older-age, and a network of regions in ventromedial prefrontal cortex, posterior cingulate, left angular and middle frontal gyri that showed decreased modulation at the transition from younger to middle-age. Critically, older adults who maintained negative modulation to difficulty showed higher task accuracy. Further, individuals who showed greater coupling between positive and negative modulation performed better on a fluid reasoning task. Age-related preservation of coupled modulation in both cognitive control regions and regions typically associated with default network may be a salient marker of how the brain adapts to maintain cognitive function as we age.
•BOLD activity is up-modulated and down-modulated in response to cognitive difficulty.•Both positive modulation and negative modulation weaken with increasing age.•Negative modulation weakens earlier in the lifespan than positive modulation.•Greater coupling of positive and negative modulation predicts higher fluid reasoning.•Greater negative modulation in older adults predicts better task accuracy.
Journal Article
My flawless life
\"At the most elite private school in Washington, DC., whenever anyone has a problem that they need to go away, they hire Hana Yang Lerner. Hana is a fixer. She knows who to call, what to say, and how to make sure secrets stay where they belong--buried. She can fix anything. Except her own life, which was destroyed when her father, senator Skip Lerner, was arrested for an accident that left one woman nearly dead. Now Hana's reputation is ruined and her friends are gone. So when she gets a job from an anonymous client called 'Three' to follow her former best friend, Luce Herrera, Hana realizes this might be her way of getting back her old life. But the dangerous thing about digging is that you never know what you'll unearth. As Hana uncovers a dark truth about her supposedly flawless classmates, she's forced to face a secret of her own\"-- Provided by publisher.
Book
Simple life-history traits explain key effective population size ratios across diverse taxa
Effective population size (Ne) controls both the rate of random genetic drift and the effectiveness of selection and migration, but it is difficult to estimate in nature. In particular, for species with overlapping generations, it is easier to estimate the effective number of breeders in one reproductive cycle (Nb) than Ne per generation. We empirically evaluated the relationship between life history and ratios of Ne, Nb and adult census size (N) using a recently developed model (agene) and published vital rates for 63 iteroparous animals and plants. Nb/Ne varied a surprising sixfold across species and, contrary to expectations, Nb was larger than Ne in over half the species. Up to two-thirds of the variance in Nb/Ne and up to half the variance in Ne/N was explained by just two life-history traits (age at maturity and adult lifespan) that have long interested both ecologists and evolutionary biologists. These results provide novel insights into, and demonstrate a close general linkage between, demographic and evolutionary processes across diverse taxa. For the first time, our results also make it possible to interpret rapidly accumulating estimates of Nb in the context of the rich body of evolutionary theory based on Ne per generation.
Journal Article
The outsiders
The struggle of three brothers to stay together after their parents' death and their quest for identity among the conflicting values of their adolescent society.
Book
Looking beyond Body Structure and Function: ICF Foci and Who Is Being Assessed in Research about Adolescents and Young Adults with Cerebral Palsy—A Scoping Review
Purpose: The purpose of this study is to summarize the ICF foci, looking beyond body structures and function, and to analyze who has been assessed in research about adolescents and young adults (AYAs) with CP in the phase of transition to adulthood. Method: Medline, EMBASE, PsycINFO, and CINAHL databases were searched using terms related to cerebral palsy, adolescents/young adults, health development, participation, and independence. Studies including youth with CP (13–30 years old) published in English from 2014 to 2021 were considered. The methods of assessment reported in the included studies were used to identify the ICF foci and who was assessed. Results: In this study, 86 studies were reviewed. The main ICF foci are activity and participation (51% of the studies), personal factors (23%), ICF not covered (14%), ICF not defined (9%), with environmental factors being the least focused ICF component (3%). Most studies assessed AYAs directly (49% of studies). Conclusions: Activity- and participation-related constructs are the leading research focus of studies, and more attention is needed concerning environmental factors. AYAs are the main source of information, and the perspectives of other key figures are also being valued. To bridge the gap between child and adult health care, a broader view of health development and approaches to explore AYA developmental issues must be taken.
Journal Article