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This is a call : the life and times of Dave Grohl
The epic story of a singular career that includes Nirvana, Foo Fighters, Queens of the Stone Age, and Them Crooked Vultures. Based on ten years of original, exclusive interviews with the man himself and conversations with a legion of musical associates like Queens of the Stone Age frontman Josh Homme, DC punk legend Ian MacKaye, and Nevermind producer Butch Vig, this is Grohl's story. He speaks candidly and honestly about Kurt Cobain, the arguments that almost tore Nirvana apart, the feuds that threatened to derail the Foo Fighters' global success, and the dark days that almost caused him to quit music for good.
Book
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (
P
< 5 × 10
−8
), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.
Genetic correlates of obesity
In the second of two Articles in this issue from the GIANT Consortium, Elizabeth Speliotes and collegues conducted a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), commonly used to define obesity and assess adiposity, to find 97 BMI-associated loci, of which 56 were novel. Many of these loci have significant effects on other metabolic phenotypes. The 97 loci account for about 2.7% of BMI variation, and genome-wide estimates suggest common variation accounts for more than 20% of BMI variation. Pathway analyses implicate the central nervous system in obesity susceptibility including synaptic function, glutamate signaling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Journal Article
Social networks and regional identity in Bronze Age Italy
\"This book takes an innovative approach to detecting regional groupings in peninsular Italy during the Late Bronze Age, a notoriously murky period of Italian prehistory. Applying social network analysis to the distributions of imports and other distinctive objects, Emma Blake reveals previously unrecognized exchange networks that are in some cases the precursors of the named peoples of the first millennium BC: the Etruscans, the Veneti, and others. In a series of regional case studies, she uses quantitative methods to both reconstruct and analyze the character of these early networks and posits that, through path dependence, the initial structure of the networks played a role in the success or failure of the groups occupying those same regions in later times. This book thus bridges the divide between Italian prehistory and the Classical period, and demonstrates that Italy's regionalism began far earlier than previously thought\"-- Provided by publisher.
Book
Primary Sjögren’s Syndrome of Early and Late Onset: Distinct Clinical Phenotypes and Lymphoma Development
To study the clinical, serological and histologic features of primary Sjögren's syndrome (pSS) patients with early (young ≤35 years) or late (old ≥65 years) onset and to explore the differential effect on lymphoma development.
From a multicentre study population of 1997 consecutive pSS patients, those with early or late disease onset, were matched and compared with pSS control patients of middle age onset. Data driven analysis was applied to identify the independent variables associated with lymphoma in both age groups.
Young pSS patients (19%, n = 379) had higher frequency of salivary gland enlargement (SGE, lymphadenopathy, Raynaud's phenomenon, autoantibodies, C4 hypocomplementemia, hypergammaglobulinemia, leukopenia, and lymphoma (10.3% vs. 5.7%, p = 0.030, OR = 1.91, 95% CI: 1.11-3.27), while old pSS patients (15%, n = 293) had more frequently dry mouth, interstitial lung disease, and lymphoma (6.8% vs. 2.1%, p = 0.011, OR = 3.40, 95% CI: 1.34-8.17) compared to their middle-aged pSS controls, respectively. In young pSS patients, cryoglobulinemia, C4 hypocomplementemia, lymphadenopathy, and SGE were identified as independent lymphoma associated factors, as opposed to old pSS patients in whom SGE, C4 hypocomplementemia and male gender were the independent lymphoma associated factors. Early onset pSS patients displayed two incidence peaks of lymphoma within 3 years of onset and after 10 years, while in late onset pSS patients, lymphoma occurred within the first 6 years.
Patients with early and late disease onset constitute a significant proportion of pSS population with distinct clinical phenotypes. They possess a higher prevalence of lymphoma, with different predisposing factors and lymphoma distribution across time.
Journal Article
Gap life
\"Cray got into the same college his father attended and is expected to go. And to go pre-med. And to get started right away. His parents are paying the tuition. It should be an easy decision. But it's not. All Cray knows is that what's expected of him doesn't feel right ... Until he meets Rayne, a girl who is taking a gap year, and who helps him find his first real job, at a home of four adults with developmental disabilities. What he learns about himself and others will turn out to be more than any university could teach him and twice as difficult\"--Provided by publisher.
Book
Establishment of age group classification for risk stratification in glioma patients
Background
Age is associated with the prognosis of glioma patients, but there is no uniform standard of age-group classification to evaluate the prognosis of glioma patients. In this study, we aimed to establish an age group classification for risk stratification in glioma patients.
Methods
1502 patients diagnosed with gliomas at Nanfang Hospital between 2000 and 2018 were enrolled. The WHO grade of glioma was used as a dependent variable to evaluate the effect of age on risk stratification. The evaluation model was established by logistic regression, and the Akaike information criterion (AIC) value of the model was used to determine the optimal cutoff points for age-classification. The differences in gender, WHO grade, pathological subtype, tumor cell differentiation, tumor size, tumor location, and molecular markers between different age groups were analyzed. The molecular markers included GFAP, EMA, MGMT, P53, NeuN, Oligo2, EGFR, VEGF, IDH1, Ki-67, PR, CD3, H3K27M, TS, and 1p/19q status.
Results
The proportion of men with glioma was higher than that of women with glioma (58.3% vs 41.7%). Analysis of age showed that appropriate classifications of age group were 0–14 years old (pediatric group), 15–47 years old (youth group), 48–63 years old (middle-aged group), and ≥ 64 years old (elderly group).The proportions of glioblastoma and large tumor size (4–6 cm) increased with age (
p
= 0.000,
p
= 0.018, respectively). Analysis of the pathological molecular markers across the four age groups showed that the proportion of patients with larger than 10% area of Ki-67 expression or positive PR expression increased with age (
p
= 0.000,
p
= 0.017, respectively).
Conclusions
Appropriate classifications of the age group for risk stratification are 0–14 years old (pediatric group), 15–47 years old (young group), 48–63 years old (middle age group) and ≥ 64 years old (elderly group). This age group classification is effective in evaluating the risk of glioblastoma in glioma patients.
Journal Article
Injury Risk and Injury Burden Are Related to Age Group and Peak Height Velocity Among Talented Male Youth Soccer Players
Background:
The relationship between injury risk (IR) in age groups and periods around peak height velocity (PHV) remains unclear. PHV is defined as the moment of the largest increase in body height.
Purpose:
To investigate injury risk and injury burden as functions of growth velocity (periods around PHV) and chronological age groupings (under 12 years [U12] to U19) in talented youth male soccer players.
Study Design:
Cohort study; Level of evidence, 2.
Methods:
A total of 170 players from the youth academy of a Dutch soccer club (highest professional league: Eredivisie) were observed for 1 to 3 seasons. Injuries, exposure, PHV age, and chronological age were registered. The injury incidence density (IID) and injury burden per 1000 hours of soccer participation, with 95% CIs, were calculated for 5 PHV periods and 7 age groups. These were compared with the overall cohort results using incidence ratios (IRs) and burden ratios (BRs) with 95% CIs.
Results:
The mean age at PHV was 14.4 ± 0.65 years (range, 12.8-16.5 years). The mean IID for the total cohort was 8.34 injuries per 1000 hours (95% CI, 7.71-9.02). Compared with the overall mean, a significantly higher IID was found for PHV period 4+5 (IR, 1.31 [95% CI, 1.00-1.71]; P = .049) and for the U15 group (IR, 1.49 [95% CI, 1.24-1.79]; P < .001). The overall injury burden was 58.37 injury days per 1000 hours (95% CI, 56.66-60.13). In PHV period 4+5, the injury burden was significantly higher (BR, 1.53 [95% CI, 1.39-1.68]; P < .001) when compared with the overall mean. Also, compared with the overall mean, the injury burden was higher in the U16 (BR, 1.48 [95% CI, 1.39-1.58]; P < .001), U15 (BR, 1.28 [95% CI, 1.19-1.38]; P < .001), and U17 groups (BR, 1.21 [95% CI, 1.13-1.31]; P < .001).
Conclusion:
Talented young soccer players were more prone to injuries during the 6 months after PHV (31% above overall mean) as well as in the U15 group (49% above overall mean). Based on the higher injury burden in the U16 (48%), U15 (28%), and U17 (21%) groups, we suggest that research on injury risk factors and preventive measures should primarily target these age groups. Additional interventions based on PHV may be of limited value from a screening perspective. Further research is needed on the interaction between age groups and PHV periods.
Journal Article
COVID-19 case fatality risk by age and gender in a high testing setting in Latin America: Chile, March–August 2020
Background
Early severity estimates of coronavirus disease 2019 (COVID-19) are critically needed to assess the potential impact of the ongoing pandemic in different demographic groups. Here we estimate the real-time delay-adjusted case fatality rate across nine age groups by gender in Chile, the country with the highest testing rate for COVID-19 in Latin America.
Methods
We used a publicly available real-time daily series of age-stratified COVID-19 cases and deaths reported by the Ministry of Health in Chile from the beginning of the epidemic in March through August 31, 2020. We used a robust likelihood function and a delay distribution to estimate real-time delay-adjusted case-fatality risk and estimate model parameters using a Monte Carlo Markov Chain in a Bayesian framework.
Results
As of August 31, 2020, our estimates of the time-delay adjusted case fatality rate (CFR) for men and women are 4.16% [95% Credible Interval (CrI): 4.09–4.24%] and 3.26% (95% CrI: 3.19–3.34%), respectively, while the overall estimate is 3.72% (95% CrI: 3.67–3.78%). Seniors aged 80 years and over have an adjusted CFR of 56.82% (95% CrI: 55.25–58.34%) for men and 41.10% (95% CrI: 40.02–42.26%) for women. Results showed a peak in estimated CFR during the June peak of the epidemic. The peak possibly reflects insufficient laboratory capacity, as illustrated by high test positivity rates (33% positive 7-day average nationally in June), which may have resulted in lower reporting rates.
Conclusions
Severity estimates from COVID-19 in Chile suggest that male seniors, especially among those aged ≥ 70 years, are being disproportionately affected by the pandemic, a finding consistent with other regions. The ongoing pandemic is imposing a high death toll in South America, and Chile has one of the highest reported mortality rates globally thus far. These real-time estimates may help inform public health officials' decisions in the region and underscore the need to implement more effective measures to ameliorate fatality.
Journal Article
Athletes’ origin trends in participation and performance of master runners in the New York City marathon (1999–2024): a sex- and age-group analysis
It is well known that the fastest elite marathon runners come from East African countries such as Ethiopia and Kenya. However, to date, there is no information available on the origin of the fastest age group (master) marathoners. This study aimed to determine the countries of origin of the fastest age group marathoners who have participated in the ‘New York City Marathon’ over the past several decades. Race data from 1,009,839 runners (626,183 male and 383,656 female finishers) who completed the ‘New York City Marathon’ between 1999 and 2024 were analyzed. Participants were categorized into five-year age groups: <20, 20–24, 25–29, 30–34, 35–39, 40–44, 45–49, 50–54, 55–59, 60–64, 65–69, 70–74, and 75 + years. The data were stratified by sex (male and female) and country of origin. The dataset was organized into five performance-based subgroups: (i) the entire dataset, including all finishers by age group and nationality; (ii) the top 100 finishers per age group; (iii) the top 30 finishers per age group; (iv) the top 10 finishers per age group; and (v) the top individual from each country within each age group. Regression analyses were conducted to explore demographic predictors of marathon performance. Participation generally increased over the study period, with temporary declines during the COVID-19 pandemic; male participation consistently outnumbered female participation, the 40–44 years age group was the most represented for both sexes, and participation was lowest in the youngest (< 20 years) and oldest (75 + years) age groups. Crucially, analyses focusing on the fastest age-group marathoners revealed clear nationality-based performance patterns. In younger adult age groups (20–39 years), the fastest average race times were predominantly achieved by female and male runners from Kenya and Ethiopia. The < 20 years age category showed comparatively stronger performances from European runners, including those from Poland, Switzerland and Italy. In the 50 years and older age groups, the best average times were increasingly recorded by runners from the United States of America, Japan, Germany and Switzerland. This shift highlights a regional transition in peak marathon performance with increasing age, from East African to European, North American, and East Asian dominance.
Journal Article
Establishing altitude-based coagulation reference ranges in Western Sichuan
The diagnosis and treatment of diseases in plateau regions should incorporate altitude, sex, and age in addition to hematological indicators from plain regions. This study analyzed coagulation results among individuals living at different altitudes in the Western Sichuan Plateaus and belonging to different sex and age groups to examine patterns of change and determine normal ranges. By comparing the changes in coagulation indicators among healthy male and female residents of different age groups (< 40 years, 40–59 years, ≥ 60 years) from Guza (1,400 m), Kangding (2,500 m), Luhuo (3,400 m), and Litang (4,100 m), we analyzed the association between coagulation indicators and altitude, age, and sex. Under low temperature, hypoxia, and other plateau environment factors, coagulation indicators varied among different altitudes, with some indicators showing specific trends of change with increasing altitude. Different sexes and age groups also exhibited specific patterns of change in coagulation results. This study clarified the patterns of change in coagulation results at four different altitudes in the Western Sichuan Plateau and the effects of sex and age on coagulation function. Normal ranges of coagulation values were determined for different sexes and age groups at different altitudes, providing a scientific basis for healthcare in this region.
Journal Article