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1,597,659 result(s) for "AGEs"
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Proving woman
Around the year 1215, female mystics and their sacramental devotion were among orthodoxy’s most sophisticated weapons in the fight against heresy. Holy women’s claims to be in direct communication with God placed them in positions of unprecedented influence. Yet by the end of the Middle Ages female mystics were frequently mistrusted, derided, and in danger of their lives. The witch hunts were just around the corner. While studies of sanctity and heresy tend to be undertaken separately, Proving Woman brings these two avenues of inquiry together by associating the downward trajectory of holy women with medieval society’s progressive reliance on the inquisitional procedure. Inquisition was soon used for resolving most questions of proof. It was employed for distinguishing saints and heretics; it underwrote the new emphasis on confession in both sacramental and judicial spheres; and it heralded the reintroduction of torture as a mechanism for extracting proof through confession.
S65 Capillary carbon dioxide as a measure of disease severity in acute bronchiolitis
Carbon dioxide (CO2) using capillary blood gas (CBG) analysis is commonly used children with acute bronchiolitis. Evidence to support its use is limited.A retrospective observational study was conducted over two bronchiolitis seasons (2014 -2016) of infants admitted to a tertiary teaching hospital using patient electronic medical records. Using logistical regression models (STATA/IC 12.1) the association between CBG pCO2 and markers of disease severity (length of stay (LOS) and high dependency admission (HDU)) was examined.332 children were assessed with 526 CBG performed in 158 infants (mean age 0.31 years, 54% male, 27% premature, 77% RSV positive). The initial CBG pCO2 was a mean 5.9kPa (SD1.1) and a maximum mean of 6.4kPa (SD1.5). Median LOS was 3 days (range 0–35). A CBG pCO2 >7.0kPa during the admission (in 23% infants (36/158)) was significantly associated with younger age (OR 0.005 (95%CI 0.0007, 0.03); p<0.0001), the use of supplemental oxygen (OR 1.9 (95%CI 1.1, 3.3); p=0.033) (adjusted for age) and inspired fraction of oxygen (FiO2) (slope coefficient 2.01 (95%CI 1.08, 2.94), p<0.0001) (adjusted for age). In 62% (98/158) a CBG was performed in ED and a pCO2 >7kPa (N=26/98) in ED was significantly associated with LOS (IRR 1.4 (95%CI 1.1,1.8); p=0.008) and HDU admission (OR 3.5 (95%CI 1.7,7.8); p=0.001).CBG pCO2 >7 kPa identifies children in ED with more severe disease with longer length of stay and risk of admission to HDU. Our results suggest that CBG pCO2 may be a possible marker of severity in future intervention trials for bronchiolitis.
Reading the Middle Ages : sources from Europe, Byzantium, and the Islamic world
\"The third edition of Reading the Middle Ages retains the strengths of previous editions-thematic and geographical diversity, clear and informative introductions, and close integration with A Short History of the Middle Ages-and adds significant new material on the Mediterranean region, as well as new readings from the Byzantine and Islamic worlds. The \"Reading through Looking\" sections, designed to showcase how historians study medieval material culture, are expanded and reorganized with a special focus on material objects and weapons and warfare in the Middle Ages. The stunning color insert has been updated, several new maps have been produced, and a new genealogy on the Islamic world has been included.\"-- Provided by publisher.
F63 Preliminary results from Q-MOTOR/Q-COG analyses in the repair-hd study
BackgroundThe Q-Motor assessment battery has been designed to quantitatively measure motor deficits and progression for use in clinical studies. The assessments have shown to be able to detect subtle motor changes reliably and with absence of rater induced bias. The Q-Cog assessment battery adds assessments with an increased cognitive share, with the goal to achieve a comparable level of sensitivity for cognitive deficits of participants. The EUFP 7 funded Repair-HD (www.repair-hd.eu) study is the first to implement the Q-Cog assessments for exploratory analyses.AimsTo identify sensitive and robust measures to quantitatively track cognitive progression in HD.MethodsThe analyzed data set includes 128 participants (52 controls, 76 HD manifest TFC stage I or II, mean age: 51 (22–78), female: 54). Statistical analyses were performed using generalized linear mixed models in R. Motor and cognitive tests were included in the assessment battery.Cognitive Assessments:Force Matching: To match a visually presented force by applying pressure on a force transducer. Blinded Force Matching: Reproduction of presented force by memory (without visual feedback).Morse Code Mimicry: To tap an acoustically presented Morse code (series of short and long beeps) on a force transducer.Trail Making: Connect dots numbered from 1 to 25 (test A) or alternating digits and letters 1,A,2,B … to 13 (test B), using a 6-axis motion tracker pen.Motor Assessments:Speeded Finger Tapping, Metronome Tapping, Grasping & Lifting, Spiral Drawing.ResultsHighly significant differences between control and manifest group could be found for various variables in all performed tests. Assessment of of cognitive function using the tests described is feasible and test-retest assessment shows low variability.ConclusionWhile results from motor tasks reproduce previous findings, the cognitive assessments, too, are able to discriminate control groups from manifest population robustly. The long-term longitudinal performance, robustness and possible redundancy of the novel variables is yet to be explored. Further analysis is required to separate motor and cognitive effects through ratios of variables of the different assessments.
RESEARCH TO STRENGTHEN, INNOVATE, AND TRANSFORM AGE-FRIENDLY COMMUNITY PRACTICE
Abstract There is much research being conducted to better understand and advance age-friendly community practice. This symposium presents research from leading age-friendly researchers and practitioners across the United States. Drs. Black and Oh provide an analysis of the nation’s sectoral efforts based on progress reported by the age-friendly communities. Drs. Hernandez and Coyle will describe the research and community engagement that led to the development of an aging equity conceptual framework and examples of how it is being operationalized in the City of Boston. Drs. Greenfield and doctoral student Pope will present on a scoping review of studies in the U.S. and Canada on the range of ways in which the public sector participates in age-friendly community efforts. Drs. Coyle and Oh and doctoral students Gleason and Somerville present on a study that explored factors inhibiting communities from officially joining the age-friendly network. Dr. Perry reports on efforts to elevate the voice of older adults on social justice issues pertaining to aging in place in the domain of housing. Individual abstracts provide further detail on each study’s methods and findings.
INFLUENCES OF AGE DIVERSITY CLIMATE ON ORG PERFORMANCE: ROLE OF INCLUSION AND ORGANIZATIONAL CITIZENSHIP BEHAVIOR
Abstract With the rapidly aging population, South Korea’s workforce demographics are changing as more older adults remain in the workforce. With limited resources such as work opportunities and pensions, intergenerational conflict may arise in the workplace while employers seek to maximize organizational outcomes. The present study investigated the effects of age diversity climate on organizational performance in private sector employees by focusing on the mediating effects of inclusion and organizational citizenship behavior (OCB). The data for this study was collected online in January 2022 from 900 private sector employees aged 20 to 69 in South Korea. Age-diversity climate, sense of inclusion, OCB, and organizational performance were measured using standardized scales. To test our assumed relationships, we used structural equation modeling and executed bootstrapping procedures to test the significance of the indirect effects. Results indicated that age-diversity climate did not have a significant direct effect on organizational performance. However, the age-diversity climate has an impact on inclusion (β = .61, p < .001) and OCB (β = .13, p < .01). Inclusion showed a positive effect on OCB (β = .41, p < .001) and OCB showed a positive effect on organizational performance (β = .10, p < .05). Additionally, as hypothesized, inclusion and OCB had a mediating role in the relationship between the age-diversity climate and organizational performance (β = .05, s.e. = .02, LLCI = .003, ULCI = .095). The results of this study highlight the importance of the age-diversity climate in the workplace in aging society.