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The aim of the article is to explore the academic and administrative applications of Artificial Intelligence. Teachers have the main responsibility of teaching in any educational setting. But there are various other tasks to be performed by the teachers as well. Besides academic duty, most of the teacher’s time and educational resources are dedicated to administrative works. Artificial Intelligence Applications (AIA) are not only assisting education academically and administratively but also enhance their effectiveness. AIA provides help to teachers in various types of tasks in the shape of Learning Analytics (LA), Virtual Reality (VR), Grading/Assessments (G/A), and Admissions. It minimizes the administrative tasks of a teacher to invest more in teaching and guiding students. In the current era, where there are a lot of tasks associated with the teaching profession, AIA adds a significant contribution to enhance student learning, minimize the workload of a teacher, grade/assess the students effectively and easily, and to help in a lot of other administrative tasks. The study needs to be quantitatively checked to make it generalized and acceptable.

In rheumatoid arthritis(RA) pathogenesis, activated RA fibroblast-like synoviocytes (RA-FLSs) exhibit similar proliferative features as tumor cells and subsequent erosion to cartilage will eventually lead to joint destruction. Therefore, it is imperative to search for compounds, which can effectively inhibit the abnormal activation of RA-FLSs, and retard RA progression.3'3-Diindolylmethane (DIM), the major product of the acid-catalyzed oligomerization of indole-3-carbinol from cruciferous vegetables, has been reported to be functionally relevant to inhibition of migration, invasion and carcinogenesis in some solid tumors. In this study, we explored the anti-proliferation, anti-metastasis and anti-inflammation effects of DIM on RA-FLSs as well as the underlying molecular mechanisms. To do this, primary RA-FLSs were isolated from RA patients and an animal model. Cell proliferation, migration and invasion were measured using CCK-8, scratch, and Transwell assays, respectively. The effects of DIM on Matrix metalloproteinases (MMPs) and some inflammatory factors mRNA and key molecules such as some inflammatory factors and those involved in aberrantly-activated signaling pathway in response to tumor necrosis factor α(TNF-α), a typical characteristic mediator in RA-FLS, were quantitatively measured by real-time PCR and western blotting. Moreover, the effect of DIM on adjuvant induced arthritis(AIA) models was evaluated with C57BL/6 mice . The results showed that DIM inhibited proliferation, migration and invasion of RA-FLS . Meanwhile, DIM dramatically suppressed TNF-α-induced increases in the mRNA levels of , and ; as well as the proinflammatory factors , and β. Mechanistic studies revealed that DIM is able to suppress phosphorylated activation not only of p38, JNK in MAPK pathway but of AKT, mTOR and downstream molecules in the AKT/mTOR pathway. Moreover, DIM treatment decreased expression levels of proinflammatory cytokines in the serum and alleviated arthritis severity in the knee joints of AIA mice. Taken together, our findings demonstrate that DIM could inhibit proliferation, migration and invasion of RA-FLSs and reduce proinflammatory factors induced by TNF-α by blocking MAPK and AKT/mTOR pathway and prevent inflammation and knee joint destruction , which suggests that DIM might have therapeutic potential for RA.

Background Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibitor TAK-242 had potential as a remedy for rheumatoid arthritis. Methods The therapeutic effect of TAK-242 was tested in vitro using the human rheumatoid fibroblast-like synoviocyte (FLS) line MH7A or primary human FLS and in an adjuvant-induced arthritis (AIA) rat model. Results TAK-242 dose dependently inhibited the increased expression of IL-6, IL-8, MMP-1, and VEGF in LPS-stimulated MH7A cells. It also inhibited the expression of IL-6 and IL-8 in poly(I:C), TLR3 activator-stimulated primary FLS, but not in IL-1β-stimulated primary FLS. These findings suggest that TAK-242 blocks a specific signaling pathway to some degree. Further, TAK-242 slightly inhibited mobilization of NF-κB into nuclei. In the AIA rat model, TAK-242 significantly reversed the body weight and paw thickness of AIA rats to the normal state at a dose of 5 mg/kg, but not at 3 mg/kg, and reduced the increased serum level of IL-6 and VEGF in AIA rats. It also significantly ameliorated inflammatory symptoms of joint tissues at day 21 of treatment, according to histology and RT-PCR. Conclusions Based on the drug repositioning concept, TAK-242, which is used for the treatment of TLR4-mediated inflammatory diseases, shows potential for cost-effective development as a remedy for rheumatoid arthritis or to control the progression of RA.

Multiple uses of water aquaculture-integrated agriculture systems (AIAS) are inevitable to produce more food per drop of water to address water shortage, food insecurity, and climate change. This survey intends to outline the multiple-use water in pond-based AIAS in light of legal regulations and water salinity. Scenarios for pond-based AIA and their impact on the environment were presented and discussed. Pond-based AIA has been demonstrated to have many social, economic, and environmental benefits. Moreover, international and national experiences and attempts for genuine applications were exhibited. Throughout, pond-based AIA farming practices are seen as a proficient utilization of water that aids food sustainability. It was concluded that pond-based AIA could aid in increasing productivity, income for food producers and soil fertility, ecosystem maintenance, and adaptation to environmental change. AIAS helps adapt to and mitigate climate change by reducing waste and greenhouse gas emissions, reducing pressure on water resources, and recycling nutrients. Finally, developing and promoting the expansion of rotation of wheat-fish and pond-based AIA in the desert and encouraging global collaboration for information and knowledge transfer among different countries were discussed.

Rubia cordifolia L. (Rubiaceae), one of the traditional anti-rheumatic herbal medicines in China, has been used to treat rheumatoid arthritis (RA) since ancient times. Purpurin, an active compound of Rubia cordifolia L., has been identified in previous studies and exerts antibacterial, antigenotoxic, anticancer, and antioxidant effects. However, the efficacy and the underlying mechanism of purpurin to alleviate RA are unclear. In this study, the effect of purpurin on inflammation was investigated using macrophage RAW264.7 inflammatory cells, induced by lipopolysaccharide (LPS), and adjuvant-induced arthritis (AIA) rat was established to explore the effect of purpurin on joint damage and immune disorders; the network pharmacology and molecular docking were integrated to dig out the prospective target. Purpurin showed significantly anti-inflammatory effect by reducing the content of IL-6, TNF-α, and IL-1β and increasing IL-10. Besides, purpurin obviously improved joint injury and hypotoxicity in the liver and spleen and regulated the level of FOXP3 and CD4+/CD8+. Furthermore, purpurin reduced the MMP3 content of AIA rats. Network pharmacology and molecular docking also suggested that MMP3 may be the key target of purpurin against RA. The results of this study strongly indicated that purpurin has a potential effect on anti-RA.

Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease in which activated RA fibroblast-1ike synoviocytes (RA-FLSs) are one of the main factors responsible for inducing morbidity. Previous reports have shown that RA-FLSs have proliferative features similar to cancer cells, in addition to causing cartilage erosion that eventually causes joint damage. Thus, new therapeutic strategies and drugs that can effectively contain the abnormal hyperplasia of RA-FLSs and restrain RA development are necessary for the treatment of RA. Tanshinone IIA (Tan IIA), one of the main phytochemicals isolated from Salvia miltiorrhiza Bunge, is capable of promoting RA-FLS apoptosis and inhibiting arthritis in an AIA mouse model. In addition, RA patients treated at our clinic with Tan IIA showed significant improvements in their clinical symptoms. However, the details of the molecular mechanism by which Tan IIA effects RA are unknown. To clarify this mechanism, we evaluated the antiproliferative and inhibitory effects of proinflammatory factor production caused by Tan IIA to RA-FLSs. We demonstrated that Tan IIA can restrict the proliferation, migration, and invasion of RA-FLSs in a time- and dose-dependent manner. Moreover, Tan IIA effectively suppressed the increase in mRNA expression of some matrix metalloproteinases and proinflammatory factors induced by TNF-α in RA-FLSs, resulting in inflammatory reactivity inhibition and blocking the destruction of the knee joint. Through the integration of network pharmacology analyses with the experimental data obtained, it is revealed that the effects of Tan IIA on RA can be attributed to its influence on different signaling pathways, including MAPK, AKT/mTOR, HIF-1, and NF-kB. Taken together, these data suggest that the compound Tan IIA has great therapeutic potential for RA treatment.

The integration of Artificial Intelligence (AI) in education is reshaping teaching and learning paradigms, transforming AI from a passive tool into an adaptive, autonomous agent capable of complex, human-like interactions. This shift has been accelerated by the emergence of generative AI capable of autonomous behaviors and adaptive learning. While the Technological Pedagogical Content Knowledge (TPACK) framework has long guided educators in technology integration, its foundational assumptions about technology as static and teacher-controlled are increasingly lacking flexibility to accommodate the dynamic, interactive nature of AI. This paper introduces AIA-PCEK (Artificial Intelligence Agent - Pedagogical Content Ethical Knowledge), a framework that reconceptualizes teacher knowledge by integrating AI-agent literacy, ethical oversight, adaptive content management, and the cultivation of critical thinking. To support the development of AIA-PCEK, a bibliometric analysis was conducted using major academic databases (Scopus, Web of Science, Google Scholar), covering literature from 2006 to 2023. These findings were triangulated with qualitative insights from the Erasmus + VOLCANIC project, which trained in-service teachers in AI-enhanced pedagogies. This study positions AIA-PCEK as a comprehensive model that enables educators to address the pedagogical, ethical, and interactive dimensions of AI in classrooms, providing strategies for responsible integration while fostering student autonomy and critical thinking in AI-supported environment.

Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease associated with oxidative stress that causes excruciating pain, discomfort, and joint destruction. Ebselen (EB), a synthesized versatile organo-selenium compound, protects cells from reactive oxygen species (ROS)-induced injury by mimicking glutathione peroxidase (GPx) action. This study aimed to investigate the antioxidant and anti-inflammatory effects of EB in an arthritic irradiated model. This goal was achieved by subjecting adjuvant-induced arthritis (AIA) rats to fractionated whole body γ-irradiation (2 Gy/fraction once per week for 3 consecutive weeks, for a total dose of 6 Gy) and treating them with EB (20 mg/kg/day, p.o) or methotrexate (MTX; 0.05 mg/kg; twice/week, i.p) as a reference anti-RA drug. The arthritic clinical signs, oxidative stress and antioxidant biomarkers, inflammatory response, expression of NOD-like receptor protein-3 (NLRP-3) inflammasome, receptor activator of nuclear factor κB ligand (RANKL), nuclear factor-κB (NF-κB), apoptotic indicators (caspase 1 and caspase 3), cartilage integrity marker (collagen-II), and histopathological examination of ankle joints were assessed. EB notably improved the severity of arthritic clinical signs, alleviated joint histopathological lesions, modulated oxidative stress and inflammation in serum and synovium, as well as reduced NLRP-3, RANKL, and caspase3 expression while boosting collagen-II expression in the ankle joints of arthritic and arthritic irradiated rats with comparable potency to MTX. Our findings suggest that EB, through its antioxidant and anti-inflammatory properties, has anti-arthritic and radioprotective properties in an arthritic irradiated model.

Achieving common prosperity and promoting coordinated regional development are key objectives of China’s economic and social development in the new era. The eastern, western, and northern regions of Guangdong (hereafter referred to as “the Regions”) possess abundant agricultural resources and serve as significant agricultural development zones within the province. A critical challenge for Guangdong’s high-quality development lies in how to enhance farmers’ income (FI) through agricultural industrial agglomeration (AIA), reduce economic disparities across regions, achieve coordinated regional development, and promote common prosperity. This study employs panel data from 12 prefecture-level cities in the Regions from 2012 to 2022 to examine the dynamic evolution of AIA and its impact on (FI). It focuses on the mechanisms through which industrial agglomeration influences income growth and explores the heterogeneity in its effects. The findings indicate that the impact of AIA on FI follows a stage-specific U-shaped pattern. Agricultural productivity mediates this relationship, demonstrating that industrial agglomeration enhances FI by improving production efficiency. However, the level of regional industrialization weakens the positive effect of AIA on income growth. To fully leverage the benefits of AIA in the Regions, this study recommends optimizing the spatial distribution of agricultural industries, integrating regional development advantages, advancing industrialization, improving rural infrastructure, and implementing region-specific policies. These measures aim to increase FI, narrow regional economic disparities in Guangdong, and achieve common prosperity.

Abstract Twelve adult beagle dogs (10.6 ± 1.4 kg) were fed extruded dog diets in which the starch sources were whole sorghum, sorghum flour, sorghum mill-feed, or an equal combination of rice, corn, and wheat. The experiment was conducted as a replicated Latin square design digestibility study. Estimates of fecal organic matter (OM), crude protein (CP), crude fat (CF), and gross energy (GE) outputs were determined by four methods: total fecal collection (TFC), chromic oxide (Cr2O3), titanium dioxide (TiO2), and acid insoluble ash (AIA). The correlation among the fecal output estimates by the four methods by partial correlation coefficients from the Error SSCP Matrix (Pearson) were considered significant at P < 0.05. The external markers, Cr2O3 and TiO2, had a higher (P < 0.05) OM fecal output Pearson correlation to TFC than the intrinsic marker AIA (R = 0.931 for Cr2O3 vs. TiO2; R = 0.559 for TFC vs. Cr2O3; R = 0.592 for TFC vs. TiO2; R = 0.291 for AIA vs. TFC). Interestingly, TiO2 highly correlated (P < 0.05) to Cr2O3 (R = 0.93 for OM), and was also correlated highly to TFC and AIA. The study suggests that TiO2 may be a preferred marker to estimate fecal output in dogs vs. Cr2O3. The use of AIA represents a potential option for determining digestibility for diets in which external markers are impractical.