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[...]in this investigation an attempt was made to develop oral disintegrating tablets of Doxofylline with super disintegrating agents like Sodium starch glycolate (SSG), Crospovidone and Ac-Di-Sol. The disintegration time for ODTs generally ranges from several seconds to about a minute.3'4 5 The ideal characteristics of a drug for oral dispersible tablet include * Ability to permeate the oral mucosa. * Very bitter or unacceptable taste and odor drugs are unsuitable for ODT6 Desired criteria for ODTs: * ODT should leave minimal or no residue in mouth after oral administration, compatible with pleasing mouth feel. * Be portable and without fragility concern.7,8 MATERIALS: [...]concluded that F6 Formulation (containing Crospovidone) was optimized better formulation.

Pregabalin is used for treating pain caused by neurologic diseases such as neuralgias as well as seizures. In the present work, fast dissolving tablets of Pregabalin were prepared by direct compression method with a view to enhance patient compliance, for the treatment of epilepsy. Fast dissolving tablets were disintegrated in the mouth and were dissolved within a matter of few seconds without need of water. Fast dissolving tablets (FDTs) were prepared using different concentration of superdisintegrants and evaluated for the pre-compression parameters. The prepared tablets were evaluated for post compressional evaluation. It was observed that wetting time of formulations containing Crospovidone was least and tablets showed fastest disintegration. The drug release from fast dissolving tablets (FDTs) increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing Crospovidone.

The purpose of this study was to develop formulations and systematically evaluate in vitro performances of super porous hydrogel composites of Metoprolol Tartrate. A cross-over design was employed in formulating the SPHC with variation in polymer concentration (N, N-methylene-bisacrylamide (1–3%) and Ac-Di-Sol (200-300mg)). Study the effect of variation on swelling time, mechanical properties and in vitro drug release. The result shows that increase in Ac-Di-Sol concentration also increase in mechanical strength where as 2% of Bis concentration have less swelling time. In-vitro release data show that best result at optimum concentration of Bis (2%) and Ac-Di-Sol concentration (250mg).

Asthma is an inflammatory disorder that results in the obstruction of air pathways and causes difficulty in breathing. Oral dosage forms associated with lag time and delayed onset of action are among the available means of treatment. However, aerosols and parenterals have a rapid onset of action but strongly affect the patient compliance. Thus, an attempt was made to improve the onset of action of bronchodilator used commonly in the treatment of asthma. Fast dissolving tablets of terbutaline sulfate were prepared by the direct compression method after incorporating superdisintegrants such as Explotab, Ac-Di-Sol and Polyplasdone XL in different concentrations. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, wetting time, drug content, water absorption ratio, in vitro dispersion time, in vitro disintegration time and in vitro drug release. Among all, the formulation F9 (containing 5% w/w concentration of Polyplasdone XL) was considered to be the best formulation, which releases up to 99.33% of the drug in 10 min.