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"Accessories"
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\"Using clear, illustrated step-by-step directions, these books explain how to create funky accessories with little bits of fabric, ribbon, buttons, and more. Basic sewing skills are taught, and ideas for other crafts are prompted. Equipment resources and glossary are included\"--Provided by publisher.
Book
Intraoperative Brief Electrical Stimulation of the Spinal Accessory Nerve (BEST SPIN) for prevention of shoulder dysfunction after oncologic neck dissection: a double-blinded, randomized controlled trial
Background
Shoulder dysfunction is common after neck dissection for head and neck cancer (HNC). Brief electrical stimulation (BES) is a novel technique that has been shown to enhance neuronal regeneration after nerve injury by modulating
the
brain-derived neurotrophic growth factor (BDNF) pathways. The objective of this study was to evaluate the effect of BES on postoperative shoulder function following oncologic neck dissection.
Methods
Adult participants with a new diagnosis of HNC undergoing Level IIb +/− V neck dissection were recruited. Those in the treatment group received intraoperative BES applied to the spinal accessory nerve (SAN) after completion of neck dissection for 60 min of continuous 20 Hz stimulation at 3-5 V of 0.1 msec balanced biphasic pulses, while those in the control group received no stimulation (NS). The primary outcome measured was the Constant-Murley Shoulder (CMS) Score, comparing changes from baseline to 12 months post-neck dissection. Secondary outcomes included the change in the Neck Dissection Impairment Index (ΔNDII) score and the change in compound muscle action potential amplitude (ΔCMAP) over the same period.
Results
Fifty-four patients were randomized to the treatment or control group with a 1:1 allocation scheme. No differences in demographics, tumor characteristics, or neck dissection types were found between groups. Significantly lower ΔCMS scores were observed in the BES group at 12 months, indicating better preservation of shoulder function (
p
= 0.007). Only four in the BES group compared to 17 patients in the NS groups saw decreases greater than the minimally important clinical difference (MICD) of the CMS (
p
= 0.023). However, NDII scores (
p
= 0.089) and CMAP amplitudes (
p
= 0.067) between the groups did not reach statistical significance at 12 months. BES participants with Level IIb + V neck dissections had significantly better ΔCMS and ΔCMAP scores at 12 months (
p
= 0.048 and
p
= 0.025, respectively).
Conclusions
Application of BES to the SAN may help reduce impaired shoulder function in patients undergoing oncologic neck dissection, and may be considered a viable adjunct to functional rehabilitation therapies.
Trial registration
Clinicaltrials.gov (
NCT02268344
, October 17, 2014).
Journal Article
I can make my own accessories : easy-to-follow patterns to make and customize fashion accessories
Provides step-by-step instructions and actual-size patterns to make a wide range of fun fashion accessories.
Book
The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19
The devastating effects of the recent global pandemic (termed COVID-19 for “coronavirus disease 2019”) caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) are paramount with new cases and deaths growing at an exponential rate. In order to provide a better understanding of SARS CoV-2, this article will review the proteins found in the SARS CoV-2 that caused this global pandemic.
Journal Article
The art of the scarf : from classic knots and chic neckties, to stylish turbans, makeshift bags and more
Explains \"how to adapt your scarf to your personal style. From bold bows to more subtle knots, there is something for every scarf shape, texture, and taste\"--Amazon.com.
BOOK
Characterization of accessory genes in coronavirus genomes
Background
The Covid19 infection is caused by the SARS-CoV-2 virus, a novel member of the coronavirus (CoV) family. CoV genomes code for a ORF1a / ORF1ab polyprotein and four structural proteins widely studied as major drug targets. The genomes also contain a variable number of open reading frames (ORFs) coding for accessory proteins that are not essential for virus replication, but appear to have a role in pathogenesis. The accessory proteins have been less well characterized and are difficult to predict by classical bioinformatics methods.
Methods
We propose a computational tool GOFIX to characterize potential ORFs in virus genomes. In particular, ORF coding potential is estimated by searching for enrichment in motifs of the
X
circular code, that is known to be over-represented in the reading frames of viral genes.
Results
We applied GOFIX to study the SARS-CoV-2 and related genomes including SARS-CoV and SARS-like viruses from bat, civet and pangolin hosts, focusing on the accessory proteins. Our analysis provides evidence supporting the presence of overlapping ORFs 7b, 9b and 9c in all the genomes and thus helps to resolve some differences in current genome annotations. In contrast, we predict that ORF3b is not functional in all genomes. Novel putative ORFs were also predicted, including a truncated form of the ORF10 previously identified in SARS-CoV-2 and a little known ORF overlapping the Spike protein in Civet-CoV and SARS-CoV.
Conclusions
Our findings contribute to characterizing sequence properties of accessory genes of SARS coronaviruses, and especially the newly acquired genes making use of overlapping reading frames.
Journal Article
PEDAGOGY CORNER: EQUIPMENT EFFICIENCY
There are incredible options available to us: instruments, mouthpieces, ligatures, reeds, barrels, bells... where to begin!? Working equipment that allows us to be the musician we aspire to be is essential to our success. CRACK PREVENTION Be aware of instrument care during the colder months or in a cold space. If a clarinet cracks through the top tone holes, you will likely feel a lack of sustainability, inconsistent control in the upper register, pitch issues, and resistance that might go in and out depending on how open or closed the crack might be. Many players use a thumb position that is too low which can precipitate injury and tension Take a moment and pick up a cup or water bottle.
Journal Article
The pocket square : 22 essential folds
\"When, where, and how should a gentleman wear the perfect pocket square? This bold accessory adds the final flourish and character to a well-dressed man's wardrobe. As delightfully entertaining as it is useful, the guide features twenty-two pocket square folds, from the simple and elegant Presidential to the complex and flamboyant Bouquet. Each fold is accompanied by easy-to-follow diagrams, bold color illustrations of how to wear a pocket square with panache, and brief descriptions and advice on when to wear each style.\"--Amazon.com.
BOOK
Preoperative ultrasound accurately characterizes surgically confirmed extracranial spinal accessory nerve injuries
Abstract ObjectiveTo determine the accuracy of preoperative ultrasound and MRI in surgically confirmed spinal accessory nerve injuries and present the benefits of a multimodality image review.Materials and methodsA retrospective review of 38 consecutive patients referred to a peripheral nerve surgical practice at an academic teaching hospital with surgically confirmed spinal accessory nerve injuries. All cases were reviewed for patient demographics, date and cause of injury, preoperative EMG, and surgical diagnosis and management. Additionally, prospective interpretation of preoperative ultrasound and MRI reports were reviewed for concordance or discordance with the surgical diagnosis.ResultsIatrogenic injury was present in 37 (97%) cases and most commonly a result of an excisional lymph node biopsy (68%). Surgically confirmed spinal accessory nerve injury diagnoses consisted of 25 (66%) stump neuromas and 13 (34%) incomplete nerve injuries. Nine months was the average time from injury to surgery. Twenty-nine patients underwent preoperative ultrasound and/or MRI evaluation: 12 ultrasound only, 10 MRI only, and seven with both ultrasound and MRI. Eighteen (95%) preoperative ultrasound reports compared to four (24%) preoperative MRI reports were concordant with the surgical diagnosis. In the seven cases with both preoperative ultrasound and MRI, six had discordant ultrasound and MRI imaging diagnoses for which the ultrasound was concordant with the surgical diagnoses in all cases.ConclusionPreoperative ultrasound more accurately characterizes spinal accessory nerve injuries compared to MRI and should serve as the modality of choice when a spinal accessory nerve injury is suspected.
Journal Article