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Contactless manipulation of microparticles using acoustic waves holds promise for applications ranging from cell sorting to threedimensional (3D) printing and tissue engineering. However, the unique potential of acoustic trapping to be applied in biomedical settings remains largely untapped. In particular, the main advantage of acoustic trapping over optical trapping, namely the ability of sound to propagate through thick and opaque media, has not yet been exploited in full. Here we demonstrate experimentally the use of the recently developed technique of single-beam acoustical tweezers to trap microbubbles, an important class of biomedically relevant microparticles. We show that the region of vanishing pressure of a propagating vortex beam can confine a microbubble by forcing low-amplitude, nonspherical, shape oscillations, enabling its full 3D positioning. Our interpretation is validated by the absolute calibration of the acoustic trapping force and the direct spatial mapping of isolated bubble echos, for which both find excellent agreement with our theoretical model. Furthermore, we prove the stability of the trap through centimeter-thick layers of bio-mimicking, elastic materials. Finally, we demonstrate the simultaneous trapping of nanoparticle-loaded microbubbles and activation with an independent acoustic field to trigger the release of the nanoparticles. Overall, using exclusively acoustic powering to position and actuate microbubbles paves the way toward controlled delivery of drug payloads in confined, hard-to-reach locations, with potential in vivo applications.

An increasing number of individuals are acquiring proficiency in Mandarin, signifying the growing significance of employing computer-assisted pronunciation training systems for Mandarin learners. One pivotal component within these systems is the technique for identifying and addressing mispronunciations, known as Mispronunciation Detection and Diagnosis (MDD). Recently, certain end-to-end techniques have tried to fuse features of prompt text and acoustic features into the model for training and have shown good results. However, previous approaches have fused acoustic features with prompt text features by a simple attention mechanism. In this paper, we posit that the impact of text features varies significantly when mapped to distinct acoustic characteristics. Furthermore, we propose that the prompt text can lead the model towards achieving an integrated text-audio representation, thereby enhancing the inference quality. Hence, this article presents a model aimed at detecting and diagnosing mispronunciations. The model utilizes a bidirectional attention mechanism to integrate acoustic and prompt text features. Good results were achieved by conducting experiments on a self-built dataset of short Mandarin read-aloud texts.

Background Mild-hyperthermia therapy (40–45 °C) with high-intensity focused ultrasound (HIFU) is a technique being considered in a number of different treatments such as thermally activated drug delivery, immune-stimulation, and as a chemotherapy adjuvant. Mechanical damage and loss of cell viability associated with HIFU-induced acoustic cavitation may pose a risk during these treatments or may hinder their success. Here we present a method that achieves mild heating and reduces cavitation by using a multi-focused HIFU beam. We quantify cavitation level and temperature rise in multi-focal sonications and compare it to single-focus sonications at the transducer geometric focus. Methods Continuous wave sonications were performed with the Sonalleve V2 transducer in gel phantoms and pork at 5, 10, 20, 40, 60, 80 acoustic watts for 30 s. Cavitation activity was measured with two ultrasound (US) imaging probes, both by computing the raw channel variance and using passive acoustic mapping (PAM). Temperature rise was measured with MR thermometry at 3 T. Cavitation and heating were compared for single- and multi-focal sonication geometries. Multi-focal sonications used four points equally spaced on a ring of either 4 mm or 8 mm diameter. Single-focus sonications were not steered. Results Multi-focal sonication generated distinct foci that were visible in MRI thermal maps in both phantoms and pork, and visible in PAM images in phantoms only. Cavitation activity (measured by channel variance) and mean PAM image value were highly correlated (r > 0.9). In phantoms, cavitation exponentially decreased over the 30-second sonication, consistent with depletion of cavitation nuclei. In pork, sporadic spikes signaling cavitation were observed with single focusing only. In both materials, the widest beam reduced average and peak cavitation level by a factor of two or more at each power tested when compared to a single focus. The widest beam reduced peak temperature by at least 10 °C at powers above 5 W, and created heating that was more spatially diffuse than single focus, resulting in more voxels in the mild heating (3–8 °C) range. Conclusions Multi-focal HIFU can be used to achieve mild temperature elevation and reduce cavitation activity.

Optical fibres constitute an exceptional sensing platform. However, standard fibres present an inherent sensing challenge: they confine light to an inner core. Consequently, distributed fibre sensors are restricted to the measurement of conditions that prevail within the core. This work presents distributed analysis of media outside unmodified, standard fibre. Measurements are based on stimulated scattering by guided acoustic modes, which allow us to listen where we cannot look. The protocol overcomes a major difficulty: guided acoustic waves induce forward scattering, which cannot be mapped using time-of-flight. The solution relies on mapping the Rayleigh backscatter contributions of two optical tones, which are coupled by the acoustic wave. Analysis is demonstrated over 3 km of fibre with 100 m resolution. Measurements distinguish between air, ethanol and water outside the cladding, and between air and water outside polyimide-coated fibres. The results establish a new sensor configuration: optomechanical time-domain reflectometry, with several potential applications. Distributed fibre sensors are so far restricted to the monitoring of conditions within the core. Here, Bashan et al. introduce distributed optomechanical mapping of outside media, where light cannot reach. The sensor resolves forward stimulated Brillouin scattering through Rayleigh back-scatter.

Quasi-bound states in the continuum (QBICs) coupling into the propagating spectrum manifest themselves as high-quality factor (Q) modes susceptible to perturbations. This poses a challenge in predicting stable Fano resonances for realistic applications. Besides, where and when the maximum field enhancement occurs in real acoustic devices remains elusive. In this work, we theoretically predict and experimentally demonstrate the existence of a Friedrich-Wintgen BIC in an open acoustic cavity. We provide direct evidence for a QBIC by mapping the pressure field inside the cavity using a Laser Doppler Vibrometer (LDV), which provides the missing field enhancement data. Furthermore, we design a symmetry-reduced BIC and achieve field enhancement by a factor of about three compared to the original cavity. LDV measurements are a promising technique for obtaining high-Q modes’ missing field enhancement data. The presented results facilitate the future applications of BICs in acoustics as high-intensity sound sources, filters, and sensors. The authors demonstrate that laser Doppler vibrometer measurements are a powerful tool for predicting the maximum pressure enhancement of high-Q modes. The results presented enable future applications of acoustic BICs by filling the missing data gap on field enhancement.

An acoustic plasmon mode in a graphene-dielectric-metal structure has recently been spotlighted as a superior platform for strong light-matter interaction. It originates from the coupling of graphene plasmon with its mirror image and exhibits the largest field confinement in the limit of a sub-nm-thick dielectric. Although recently detected in the far-field regime, optical near-fields of this mode are yet to be observed and characterized. Here, we demonstrate a direct optical probing of the plasmonic fields reflected by the edges of graphene via near-field scattering microscope, revealing a relatively small propagation loss of the mid-infrared acoustic plasmons in our devices that allows for their real-space mapping at ambient conditions even with unprotected, large-area graphene grown by chemical vapor deposition. We show an acoustic plasmon mode that is twice as confined and has 1.4 times higher figure of merit in terms of the normalized propagation length compared to the graphene surface plasmon under similar conditions. We also investigate the behavior of the acoustic graphene plasmons in a periodic array of gold nanoribbons. Our results highlight the promise of acoustic plasmons for graphene-based optoelectronics and sensing applications. Acoustic graphene plasmons are superior to the graphene surface plasmons in field confinement and normalized propagation length, thus promising for applications. Here, the authors report near-field imaging of acoustic plasmons in high-quality CVD graphene, measure the AGP dispersion and propagation loss, and investigate their behavior in a periodic structure.

Unconventional chiral particles have recently been predicted to appear in certain three-dimensional crystal structures containing three- or more-fold linear band degeneracy points (BDPs)1–4. These BDPs carry topological charges, but are distinct from the standard twofold Weyl points or fourfold Dirac points, and cannot be described in terms of an emergent relativistic field theory1. Here we report on the experimental observation of a topological threefold BDP in a three-dimensional phononic crystal. Using direct acoustic field mapping, we demonstrate the existence of the threefold BDP in the bulk band structure, as well as doubled Fermi arcs of surface states consistent with a topological charge of 2. Another novel BDP, similar to a Dirac point but carrying non-zero topological charge, is connected to the threefold BDP via the doubled Fermi arcs. The Fermi arcs form double helicoids spanning a broad frequency range (relative bandwidth >25%). We show that the non-contractibility of these arcs gives rise to the phenomenon of topologically protected negative refraction of surface states on all surfaces of the sample. Our work paves the way to using these unconventional particles for exploring new emergent physical phenomena, and may find applications in symmetry-stabilized three-dimensional zero-index metamaterials.In acoustic metamaterials, unconventional chiral quasiparticles exhibit multifold band degeneracy points, each carrying non-zero topological charges, giving rise to the topologically protected negative surface refraction.

Ultrafast ultrasound localization microscopy can be used to detect the subwavelength acoustic scattering of intravenously injected microbubbles to obtain haemodynamic maps of the vasculature of animals and humans. The quality of the haemodynamic maps depends on signal-to-noise ratios and on the algorithms used for the localization of the microbubbles and the rendering of their trajectories. Here we report the results of benchmarking of the performance of seven microbubble-localization algorithms. We used metrics for localization errors, localization success rates, processing times and a measure of the reprojection of the localization of the microbubbles on the original beamformed grid. We combined eleven metrics into an overall score and tested the algorithms in three simulated microcirculation datasets, and in angiography datasets of the brain of a live rat after craniotomy, an excised rat kidney and a mammary tumour in a live mouse. The algorithms, metrics and datasets, which we have made openly available at https://github.com/AChavignon/PALA and https://doi.org/10.5281/zenodo.4343435 , will facilitate the identification or generation of optimal microbubble-localization algorithms for specific applications. The performance of microbubble-localization algorithms for use in ultrasound localization microscopy can now be easily benchmarked via openly available algorithms and datasets of simulated microcirculation and of in vivo and ex vivo angiography.

The establishment of multibeam echosounders (MBES), as a mainstream tool in ocean mapping, has facilitated integrative approaches towards nautical charting, benthic habitat mapping, and seafloor geotechnical surveys. The combined acoustic response of the seabed and the subsurface can vary with MBES operating frequency. At worst, this can make for difficulties in merging the results from different mapping systems or mapping campaigns. However, at best, having observations of the same seafloor at different acoustic wavelengths allows for increased discriminatory power in seabed classification and characterization efforts. Here, we present the results from trials of a multispectral multibeam system (R2Sonic 2026 MBES, manufactured by R2Sonic, LLC, Austin, TX, USA) in the Bedford Basin, Nova Scotia. In this system, the frequency can be modified on a ping-by-ping basis, which can provide multi-spectral acoustic measurements with a single pass of the survey platform. The surveys were conducted at three operating frequencies (100, 200, and 400 kHz), and the resulting backscatter mosaics revealed differences in parts of the survey area between the frequencies. Ground validation surveys using a combination of underwater video transects and benthic grab and core sampling confirmed that these differences were due to coarse, dredge spoil material underlying a surface cover of mud. These innovations offer tremendous potential for application in the area of seafloor geological and benthic habitat mapping.

Hybrid organic–inorganic perovskites (HOIPs) have become an important class of semiconductors for solar cells and other optoelectronic applications. Electron–phonon coupling plays a critical role in all optoelectronic devices, and although the lattice dynamics and phonon frequencies of HOIPs have been well studied, little attention has been given to phonon lifetimes. We report high-precision momentum-resolved measurements of acoustic phonon lifetimes in the hybrid perovskite methylammonium lead iodide (MAPI), using inelastic neutron spectroscopy to provide high-energy resolution and fully deuterated single crystals to reduce incoherent scattering from hydrogen. Our measurements reveal extremely short lifetimes on the order of picoseconds, corresponding to nanometer mean free paths and demonstrating that acoustic phonons are unable to dissipate heat efficiently. Lattice-dynamics calculations using ab initio third-order perturbation theory indicate that the short lifetimes stem from strong three-phonon interactions and a high density of low-energy optical phonon modes related to the degrees of freedom of the organic cation. Such short lifetimes have significant implications for electron–phonon coupling in MAPI and other HOIPs, with direct impacts on optoelectronic devices both in the cooling of hot carriers and in the transport and recombination of band edge carriers. These findings illustrate a fundamental difference between HOIPs and conventional photovoltaic semiconductors and demonstrate the importance of understanding lattice dynamics in the effort to develop metal halide perovskite optoelectronic devices.