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Symbolic Extensions of Amenable Group Actions and the Comparison Property
In topological dynamics, the
Of course, the statement is preceded by the
presentation of the concepts of an entropy structure and its superenvelopes, adapted from the case of
eBook
A bioorthogonal system reveals antitumour immune function of pyroptosis
Bioorthogonal chemistry capable of operating in live animals is needed to investigate biological processes such as cell death and immunity. Recent studies have identified a gasdermin family of pore-forming proteins that executes inflammasome-dependent and -independent pyroptosis
1
–
5
. Pyroptosis is proinflammatory, but its effect on antitumour immunity is unknown. Here we establish a bioorthogonal chemical system, in which a cancer-imaging probe phenylalanine trifluoroborate (Phe-BF
3
) that can enter cells desilylates and ‘cleaves’ a designed linker that contains a silyl ether. This system enabled the controlled release of a drug from an antibody–drug conjugate in mice. When combined with nanoparticle-mediated delivery, desilylation catalysed by Phe-BF
3
could release a client protein—including an active gasdermin—from a nanoparticle conjugate, selectively into tumour cells in mice. We applied this bioorthogonal system to gasdermin, which revealed that pyroptosis of less than 15% of tumour cells was sufficient to clear the entire 4T1 mammary tumour graft. The tumour regression was absent in immune-deficient mice or upon T cell depletion, and was correlated with augmented antitumour immune responses. The injection of a reduced, ineffective dose of nanoparticle-conjugated gasdermin along with Phe-BF
3
sensitized 4T1 tumours to anti-PD1 therapy. Our bioorthogonal system based on Phe-BF
3
desilylation is therefore a powerful tool for chemical biology; our application of this system suggests that pyroptosis-induced inflammation triggers robust antitumour immunity and can synergize with checkpoint blockade.
In mouse models of cancer, a biorthogonal chemical system based on desilylation catalysed by phenylalanine trifluoroborate enables the controlled release of gasdermin to induce pyroptosis selectively in tumour cells
Journal Article
Oral controlled release formulation design and drug delivery
This book describes the theories, applications, and challenges for different oral controlled release formulations.This book differs from most in its focus on oral controlled release formulation design and process development.
eBook
Motivational Dimensions in Social Movements and Contentious Collective Action
After exposing the limitations of these conflicting perspectives, Maurice Pinard elaborates on an entirely new synthesis, one that involves several motivational components. The pushing force of felt grievances, now with qualifications, is brought back but accompanied, or at times replaced, by other forces, such as feelings of moral obligation or simple aspirations. With regard to pulling factors, collective goods or goals pursued can be involved or replaced by individual material or social rewards granted to participants. Expectancy of success, a generally neglected component, also enters the picture. Finally, the effect of emotions and collective identities are among additional factors that must be considered. By developing theoretical distinctions that have important empirical implications and enriching and sharpening our understanding of the motivational factors for collective action, Pinard offers a major contribution destined to become an essential new starting point for any future writers addressing these issues.
eBook
Are collective political actions and private political actions substitutes or complements? Empirical evidence from China's private sector
This paper examines the circumstances under which collective and private corporate political actions are more likely to be substitutes or complements. Using data based on a series of nationwide surveys conducted on privately owned firms in China, I find that firms that are engaged in collective political actions are more likely to pursue private political actions. This positive relationship is stronger in less economically developed provinces and when there are greater opportunities for the state to redistribute economic resources in product and capital markets. Meanwhile, this relationship is weaker in the presence of heavier regulatory burdens and for firms in which the state has some equity or owned by individuals who had prior political careers. These findings contribute to the corporate political action literature.
Journal Article