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Cross‐adaptation occurs when exposure to one environmental stressor (e.g., heat) induces protective responses to another (e.g., hypoxia). Although post‐exercise hot‐water immersion (HWI) induces heat acclimation, its potential to elicit cross‐adaptation remains unclear. This study evaluated the effectiveness of a 6‐week post‐exercise HWI intervention on exercise performance in hypoxia (O2 = 13%). Twenty healthy volunteers (28 ± 5 years; V̇O2peak ${\\dot V_{{{\\mathrm{O}}_2}{\\mathrm{peak}}}$47.4 ± 8.9 mL kg−1 min−1; 12 males, 8 females) completed interval cycling (4×4 min at 90 ± 5% maximal heart rate, 3×/week) followed by water immersion at either 34.5°C (control) or 42°C (HWI) for 40–50 min, five times per week. Following the 6‐week intervention, the post‐exercise HWI group exhibited lower resting heart rate (P < 0.01, q = 0.02; d = −1.32) and core temperature (P < 0.01, q = 0.001; d = −1.88) and elevated haemoglobin concentration (P < 0.01, q = 0.02; d = 1.38). Compared to the control group, the HWI group also showed greater improvements in time‐to‐exhaustion (TTE) trial (P and q < 0.01; d = 1.2) under hypoxia, but not in aerobic peak power (P = 0.03, q = 0.08; d = 0.86) or peak oxygen consumption (V̇O2peak ${\\dot V_{{{\\mathrm{O}}_2}{\\mathrm{peak}}}$ ) (P = 0.04, q = 0.10; d = 0.82). Throughout the TTE, lower core temperature and tidal volume, with increased oxygen saturation and V̇O2 ${\\dot V_{{{\\mathrm{O}}_2}}}$were observed (P and q < 0.05). During hypoxic steady‐state exercise at 60% of V̇O2peak ${\\dot V_{{{\\mathrm{O}}_2}{\\mathrm{peak}}}$ , the HWI group exhibited lower core temperature and higher peripheral oxygen saturation in hypoxia. No between‐group differences were observed in mean V̇O2 ${\\dot V_{{{\\mathrm{O}}_2}}}$ , respiratory exchange ratio, heart rate or rate of perceived exertion, nor in V̇O2peak ${\\dot V_{{{\\mathrm{O}}_2}{\\mathrm{peak}}}$and aerobic peak power under normoxia (P and q > 0.05). In conclusion, post‐exercise HWI enhances maximal exercise performance under acute hypoxia, likely due to increased haemoglobin concentration, lower core temperature and improved respiratory efficiency. What is the central question of this study? Can post‐exercise hot‐water immersion (HWI) induce a cross‐adaptation effect enhancing exercise performance in acute hypoxia? What is the main finding and its importance? Six weeks of daily post‐exercise HWI at 42°C (chest level, 40–50 min) elicits a cross‐adaptation effect in healthy, active cyclists. Post‐exercise HWI intervention improves exercise performance in acute hypoxia (13% O₂, simulating ∼4300 m altitude), as demonstrated by increased time‐to‐exhaustion at 80% of V̇O2peak ${\\dot V_{{{\\mathrm{O}}_2}{\\mathrm{peak}}}$ . This improvement may be attributed to increased haemoglobin concentration, lower core temperature and enhanced respiratory efficiency (i.e., lower tidal volume, reduced V̇E ${\\dot V_{\\mathrm{E}}}$and increased absolute V̇O2 ${\\dot V_{{{\\mathrm{O}}_2}}}$and oxygen saturation).

Abstract The first night in an unfamiliar environment is marked by reduced sleep quality and changes in sleep architecture. This so-called first-night effect (FNE) is well established for two consecutive nights and lays the foundation for including an adaptation night in sleep research to counteract FNEs. However, adaptation nights rarely happen immediately before experimental nights, which raises the question of how sleep adapts over nonconsecutive nights. Furthermore, it is yet unclear, how environmental familiarity and hemispheric asymmetry of slow-wave sleep (SWS) contribute to the explanation of FNEs. To address this gap, 45 healthy participants spent two weekly separated nights in the sleep laboratory. In a separate study, we investigated the influence of environmental familiarity on 30 participants who spent two nonconsecutive nights in the sleep laboratory and two nights at home. Sleep was recorded by polysomnography. Results of both studies show that FNEs also occur in nonconsecutive nights, particularly affecting wake after sleep onset, sleep onset latency, and total sleep time. Sleep disturbances in the first night happen in both familiar and unfamiliar environments. The degree of asymmetric SWS was not correlated with the FNE but rather tended to vary over the course of several nights. Our findings suggest that nonconsecutive adaptation nights are effective in controlling for FNEs, justifying the current practice in basic sleep research. Further research should focus on trait- and fluctuating state-like components explaining interhemispheric asymmetries. Graphical Abstract Graphical Abstract

Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on the proteome and acetylome of human skeletal muscle, revealing the response of 3168 proteins and 1263 lysine acetyl-sites on 464 acetylated proteins. We identified global protein adaptations to exercise training involved in metabolism, excitation-contraction coupling, and myofibrillar calcium sensitivity. Furthermore, HIIT increased the acetylation of mitochondrial proteins, particularly those of complex V. We also highlight the regulation of exercise-responsive histone acetyl-sites. These data demonstrate the plasticity of the skeletal muscle proteome and acetylome, providing insight into the regulation of contractile, metabolic and transcriptional processes within skeletal muscle. Herein, we provide a substantial hypothesis-generating resource to stimulate further mechanistic research investigating how exercise improves metabolic health.

PurposeTo assess the performance change and physiological adaptations following nine sessions of short high-intensity interval training (HIIT) or sprint-interval training (SIT) in sprint kayakers.MethodsTwelve trained kayakers performed an incremental test and 3 time trials (200 m, 500 m and 1000 m) on a kayak ergometer. Oxygen consumption (V̇O2) and muscle oxygenation of the latissimus dorsi, biceps brachii, and vastus lateralis were measured. Athletes were then paired for sex and V̇O2max and randomized into a HIIT or a SIT training group, and performed nine training sessions before repeating the tests.ResultsTraining improved performance in HIIT (200 m: + 3.8 ± 3.1%, p = 0.06; 500 m: + 2.1 ± 4.1%, p = 0.056; 1000 m: + 3.0 ± 4.6%, p = 0.13) but changes in performance remained within the smallest worthwhile change in SIT (200 m: + 0.8 ± 4.1%, p = 0.59; 500 m: + 0.5 ± 4.1%, p = 0.87; 1000 m: + 1.3 ± 4.6%, p = 0.57). In the 1000 m, training led to a greater deoxygenation in the biceps brachii and vastus lateralis in HIIT, and in the latissimus dorsi in SIT. In HIIT, the best predictors of improvements in 1000 m performance were increases in latissimus dorsi and vastus lateralis maximal deoxygenation.ConclusionIn a group of trained sprint kayakers, greater improvements in performance can be obtained with HIIT compared with SIT, for any distance. Training did not change V̇O2peak, but increased muscle maximal deoxygenation, suggesting both HIIT and SIT elicit peripheral adaptations. Performance improvement in the 1000 m was associated with increased maximal muscle deoxygenation, reinforcing the contribution of peripheral adaptations to performance in sprint kayaking.

PurposeAerobic (AE) and resistance (RE) exercise elicit unique adaptations in skeletal muscle. The purpose here was to compare the post-exercise response of mTOR signaling and select autophagy markers in skeletal muscle to acute AE and RE.MethodsIn a randomized, cross-over design, six untrained men (27 ± 3 years) completed acute AE (40 min cycling, 70% HRmax) and RE (8 sets, 10 repetitions, 65% 1RM). Muscle biopsies were taken at baseline, and at 1 h and 4 h following each exercise. Western blot analyses were performed to examine total and phosphorylated protein levels. Upstream regulator analyses of skeletal muscle transcriptomics were performed to discern the predicted activation states of mTOR and FOXO3.ResultsCompared to AE, acute RE resulted in greater phosphorylation (P < 0.05) of mTORSer2448 at 4 h, S6K1Thr389 at 1 h, and 4E- BP1Thr37/46 during the post-exercise period. However, both AE and RE increased mTORSer2448 and S6K1Thr389 phosphorylation at 4 h (P < 0.05). Upstream regulator analyses revealed the activation state of mTOR was increased for both AE (z score, 2.617) and RE (z score, 2.789). No changes in LC3BI protein were observed following AE or RE (P > 0.05), however, LC3BII protein was decreased after both AE and RE at 1 h and 4 h (P < 0.05). p62 protein content was also decreased at 4 h following AE and RE (P < 0.05).ConclusionBoth acute AE and RE stimulate mTOR signaling and similarly impact select markers of autophagy. These findings indicate the early adaptive response of untrained human skeletal muscle to divergent exercise modes is not likely mediated through large differences in mTOR signaling or autophagy.

Abstract Study Objective Night work has detrimental impacts on sleep and performance, primarily due to misalignment between sleep–wake schedules and underlying circadian rhythms. This study tested whether circadian-informed lighting accelerated circadian phase delay, and thus adjustment to night work, compared to blue-depleted standard lighting under simulated submariner work conditions. Methods Nineteen healthy sleepers (12 males; mean ± SD aged 29 ± 10 years) participated in two separate 8-day visits approximately 1 month apart to receive, in random order, circadian-informed lighting (blue-enriched and dim, blue-depleted lighting at specific times) and standard lighting (dim, blue-depleted lighting). After an adaptation night (day 1), salivary dim-light melatonin onset (DLMO) assessment was undertaken from 18:00 to 02:00 on days 2–3. During days 3–7, participants completed simulated night work from 00:00 to 08:00 and a sleep period from 10:00 to 19:00. Post-condition DLMO assessment occurred from 21:00 to 13:00 on days 7–8. Ingestible capsules continuously sampled temperature to estimate daily core body temperature minimum (Tmin) time. Tmin and DLMO circadian delays were compared between conditions using mixed effects models. Results There were significant condition-by-day interactions in Tmin and DLMO delays (both p < .001). After four simulated night shifts, circadian-informed lighting produced a mean [95% CI] 5.6 [3.0 to 8.2] hours greater delay in Tmin timing and a 4.2 [3.0 to 5.5] hours greater delay in DLMO timing compared to standard lighting. Conclusions Circadian-informed lighting accelerates adjustment to shiftwork in a simulated submariner work environment. Circadian lighting interventions warrant consideration in any dimly lit and blue-depleted work environments where circadian adjustment is relevant to help enhance human performance, safety, and health.

Adaptation capacity is critical for maintaining cognition, yet it is understudied in groups at risk for dementia. Autonomic nervous system (ANS) is critical for neurovisceral integration and is a key contributor to adaptation capacity. To determine the central nervous system’s top-down regulation of ANS, we conducted a mechanistic randomized controlled trial study, using a 6-week processing speed and attention (PS/A)-targeted intervention. Eighty-four older adults with amnestic mild cognitive impairment (aMCI) were randomized to a 6-week PS/A-targeted intervention or an active control without PS/A. Utilizing repeated measures (i.e., PS/A test different from the intervention, resting and cognitive task-based ECG, and resting fMRI) at baseline, immediately post-intervention (post-test), and 6-month follow-up, we aimed to test whether PS/A causally influences vagal control of ANS via their shared central neural pathways in aMCI. We indexed vagal control of ANS using high-frequency heart rate variability (HF-HRV) extracted from ECG data. Functional brain connectivity patterns were extracted from fMRI using advanced statistical tools. Compared to the control group, the intervention group showed significant improvement in PS/A, HF-HRV, salience network (SN), central executive network (CEN), and frontal parietal network (FPN) connectivity at post-test; the effect on SN, CEN, and FPN remained at 6-month follow-up. Changes in PS/A and SN connectivity significantly predicted change in HF-HRV from baseline to post-test and/or 6-month-follow-up. Age, neurodegeneration, nor sex did not affect these relationships. This work provides novel support for top-down regulation of PS/A and associated SN on vagal control of ANS. Intervening PS/A may be a viable approach for promoting adaptation capacity in groups at risk for dementia. •Top-down regulation of attention & processing speed (PS/A) on vagal control exists.•Salience network pathway is shared by PS/A and vagal control.•Intervening PS/A may be a viable approach for promoting adaptation capacity.

Mobile phone texting is a common daily occurrence with a paucity of research examining corresponding gait characteristics. To date, most studies have participants walk in a straight line vs. overcoming barriers and obstacles that occur during regular walking. The aim of our study is to examine the effect of mobile phone texting during periods of cognitive distraction while walking and negotiating barriers synonymous with pedestrian traffic. Thirty participants (18-50 y) completed three randomized, counter-balanced walking tasks over a course during: (1) normal walking (control), (2) texting and walking, and (3) texting and walking whilst being cognitively distraction via a standard mathematical test performed while negotiating the obstacle course. We analyzed gait characteristics during course negotiation using a 3-dimensional motion analysis system and a general linear model and Dunnet-Hsu post-hoc procedure the normal walking condition to assess gait characteristic differences. Primary outcomes included the overall time to complete the course time and barrier contact. Secondary outcomes included obstacle clearance height, step frequency, step time, double support phase and lateral deviation. Participants took significantly longer (mean ± SD) to complete the course while texting (24.96 ± 4.20 sec) and during cognitive distraction COG (24.09 ± 3.36 sec) vs. normal walking (19.32 ± 2.28 sec; all, P<0.001). No significant differences were noted for barrier contacts (P = 0.28). Step frequency, step time, double support phase and lateral deviation all increased in duration during the texting and cognitive distraction trial. Texting and being cognitively distracted also increased obstacle clearance versus the walking condition (all, P<0.02). Texting while walking and/or being cognitively distracted significantly affect gait characteristics concordant to mobile phone usage resulting in a more cautious gate pattern. Future research should also examine a similar study in older participants who may be at a greater risk of tripping with such walking deviations.