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Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use of antibiotics for infected wound management. Hence, a versatile hydrogel dressing (rGB/QCS/PDA–PAM) exhibiting skin adaptiveness on dynamic wounds and  mild photothermal antibacterial activity is developed for safe and efficient infected wound treatment. Phenylboronic acid‐functionalized graphene (rGB) and oxadiazole‐decorated quaternary carboxymethyl chitosan (QCS) are incorporated into a polydopamine–polyacrylamide (PDA–PAM) network with multiple covalent and noncovalent bonds, which conferred the hydrogel with flexible mechanical properties, strong tissue adhesion and excellent self‐healing ability on the dynamic wounds. Moreover, the glycocalyx‐mimicking phenylboronic acid on the surface of rGB enables the hydrogel to specifically capture bacteria. The enhanced membrane permeability of QCS enhanced bacterial vulnerability to photothermal therapy（PTT）, which is demonstrated by efficient mild PTT antibacteria against methicillin‐resistant Staphylococcus aureus in vitro and in vivo at temperatures of <49.6 °C. Consequently, the hydrogel demonstrate accelerated tissue regeneration on MRSA‐infected wound in vivo, with an intact epidermis, abundant collagen deposition and prominent angiogenesis. Therefore, rGB/QCS/PDA–PAM is a versatile hydrogel dressing exhibiting inherent antibacterial activity and has considerable potential in treating wounds infected with drug‐resistant bacteria. A versatile hydrogel conferred skin adaptiveness on dynamic wound healing, including flexible mechanical properties, strong tissue adhesion and excellent self‐healing ability. Moreover, the design of specific bacterial capture, membrane puncture and enhanced near‐infrared permeability, produced a safe and efficient mild PTT antibacteria against methicillin‐resistant Staphylococcus aureus and accelerated the tissue regeneration of MRSA‐infected wounds.

The information on the projected climate changes over China is of great importance for preparing the nation’s societal adaptiveness to the future natural ecosystem. This study reports the surface mean temperature changes during 2014–2100 over China and its four sub-regions (Northern China, Northwestern China, Southern China, and the Tibetan Plateau) by analyzing 20 models from the Coupled Model Intercomparison Project Phase 6 (CMIP6) under three Shared Socio-economic Pathway (SSP) scenarios: SSP126, SSP245 and SSP585. The multi-model ensemble mean (MMEM) of 20 CMIP6 models has cold biases over China during 1979–2014, with improved performance compared with the CMIP5 models. In contrast, the CMIP6 models simulate well in the spatial climatology with lower warming rates over China. Relative to 1986–2005, the regionally averaged surface mean temperatures from the MMEM over China under SSP126, SSP245, SSP585 scenarios are projected to increase by 1.31 °C, 1.32 °C, 1.45 °C in the near-term (2021–2040), 1.75 °C, 2.06 °C, 2.66 °C in the mid-term (2041–2060), and 1.08 °C, 2.97 °C, 5.62 °C in the long-term (2081–2100), respectively. The CMIP6 models simulate accelerated warming occurs over the Northwestern China and the Tibetan Plateau, suggesting that the arid and semi-arid regions are particularly sensitive to future climate warming. We quantify uncertainty for future projections of temperature changes over China, and the main sources of uncertainty are model and scenario uncertainty particularly for the regions with the largest cold bias. This suggests that the observational constraints on these regions will lead to significant improvements for climatic projections over China.

Purpose To investigate the potential use of large language models (LLMs) in orthopaedics by presenting queries pertinent to anterior cruciate ligament (ACL) surgery to generative pre-trained transformer (ChatGPT, specifically using its GPT-4 model of March 14th 2023). Additionally, this study aimed to evaluate the depth of the LLM’s knowledge and investigate its adaptability to different user groups. It was hypothesized that the ChatGPT would be able to adapt to different target groups due to its strong language understanding and processing capabilities. Methods ChatGPT was presented with 20 questions and response was requested for two distinct target audiences: patients and non-orthopaedic medical doctors. Two board-certified orthopaedic sports medicine surgeons and two expert orthopaedic sports medicine surgeons independently evaluated the responses generated by ChatGPT. Mean correctness, completeness, and adaptability to the target audiences (patients and non-orthopaedic medical doctors) were determined. A three-point response scale facilitated nuanced assessment. Results ChatGPT exhibited fair accuracy, with average correctness scores of 1.69 and 1.66 (on a scale from 0, incorrect, 1, partially correct, to 2, correct) for patients and medical doctors, respectively. Three of the 20 questions (15.0%) were deemed incorrect by any of the four orthopaedic sports medicine surgeon assessors. Moreover, overall completeness was calculated to be 1.51 and 1.64 for patients and medical doctors, respectively, while overall adaptiveness was determined to be 1.75 and 1.73 for patients and doctors, respectively. Conclusion Overall, ChatGPT was successful in generating correct responses in approximately 65% of the cases related to ACL surgery. The findings of this study imply that LLMs offer potential as a supplementary tool for acquiring orthopaedic knowledge. However, although ChatGPT can provide guidance and effectively adapt to diverse target audiences, it cannot supplant the expertise of orthopaedic sports medicine surgeons in diagnostic and treatment planning endeavours due to its limited understanding of orthopaedic domains and its potential for erroneous responses. Level of evidence V.

Rationalization occurs when a person has performed an action and then concocts the beliefs and desires that would have made it rational. Then, people often adjust their own beliefs and desires to match the concocted ones. While many studies demonstrate rationalization, and a few theories describe its underlying cognitive mechanisms, we have little understanding of its function. Why is the mind designed to construct post hoc rationalizations of its behavior, and then to adopt them? This may accomplish an important task: transferring information between the different kinds of processes and representations that influence our behavior. Human decision making does not rely on a single process; it is influenced by reason, habit, instinct, norms, and so on. Several of these influences are not organized according to rational choice (i.e., computing and maximizing expected value). Rationalization extracts implicit information – true beliefs and useful desires – from the influence of these non-rational systems on behavior. This is a useful fiction – fiction, because it imputes reason to non-rational psychological processes; useful, because it can improve subsequent reasoning. More generally, rationalization belongs to the broader class of representational exchange mechanisms, which transfer information between many different kinds of psychological representations that guide our behavior. Representational exchange enables us to represent any information in the manner best suited to the particular tasks that require it, balancing accuracy, efficiency, and flexibility in thought. The theory of representational exchange reveals connections between rationalization and theory of mind, inverse reinforcement learning, thought experiments, and reflective equilibrium.

This study investigates users’ coping responses in the process of phishing email detection. Three common responses are identified based on the coping literature: task-focused coping, emotion-focused coping (i.e., worry and self-criticism), and avoidance coping. The three responses are used to conceptualize a higher-order construct, coping adaptiveness, that resides on a continuum between maladaptive coping and adaptive coping (manifested as increased task-focused coping and decreased emotion-focused coping and avoidance coping). Drawing on the extended parallel process model and behavioral decision-making literature, this paper examines the antecedents (i.e., perceived phishing threat, perceived detection efficacy, and phishing anxiety) and behavioral consequences (i.e., detection effort and detection accuracy) of coping adaptiveness. A survey experiment with 547 U.S. consumers was conducted. The results show that perceived detection efficacy increases coping adaptiveness. Partially mediated by phishing anxiety, perceived phishing threat decreases coping adaptiveness. Coping adaptiveness positively impacts the two objective measures in the study, detection effort and detection accuracy. The results also suggest that coping adaptiveness and detection effort have different effects on false positives compared to false negatives: detection effort fully mediates the effect of coping adaptiveness on false positive rate (or detection accuracy related to legitimate emails), but has no impact on false negatives (or detection accuracy related to phishing emails), unlike coping adaptiveness. A post hoc analysis on coping responses reveals two patterns of coping among subjects, throwing more light on coping in phishing detection. Theoretical and practical implications are discussed. The online appendix is available at https://doi.org/10.1287/isre.2016.0680 .

Driven by solid economic developments, emerging economies are experiencing significant institutional change, particularly in regulatory structures and market systems. Coupled with fierce market competition and reforms, serious challenges for the sustainable development of new ventures are created due to smallness and newness liabilities. This study examines how new ventures grow and adapt to the rapid environmental shifts in emerging economies by exploring the effects of entrepreneurial bricolage. This study found that entrepreneurial bricolage has a positive impact on both new venture growth and adaptiveness. Further, institutional voids have contrasting effects on these two relationships. The effectiveness of entrepreneurial bricolage on new venture growth is stronger in a context with serious institutional voids, while the effectiveness of entrepreneurial bricolage on new venture adaptiveness is weaker in a context with serious institutional voids. These findings not only enrich our knowledge on the implications of entrepreneurial bricolage, but also advance our understanding of the emerging economy context.

Birds have many kinds of internal and external parasites, including viruses, bacteria and fungi, as well as protozoa, helminths and arthropods. Because parasites have negative effects on host fitness, selection favours the evolution of anti-parasite defences, many of which involve behaviour. We provide a brief review of anti-parasite behaviours in birds, divided into five major categories: (i) body maintenance, (ii) nest maintenance, (iii) avoidance of parasitized prey, (iv) migration and (v) tolerance. We evaluate the adaptive significance of the different behaviours and note cases in which additional research is particularly needed. We briefly consider the interaction of different behaviours, such as sunning and preening, and how behavioural defences may interact with other forms of defence, such as immune responses. We conclude by suggesting some general questions that need to be addressed concerning the nature of anti-parasite behaviour in birds. This article is part of the Theo Murphy meeting issue ‘Evolution of pathogen and parasite avoidance behaviours’.

Robotic locomotion in unstructured terrain demands an agile, adaptive, and energy-efficient architecture. To traverse such terrains, legged robots use rigid electromagnetic motors and sensorized drivetrains to adapt to the environment actively. These systems struggle to compete with animals that excel through their agile and effortless motion in natural environments. We propose a bio-inspired musculoskeletal leg architecture driven by antagonistic pairs of electrohydraulic artificial muscles. Our leg is mounted on a boom arm and can adaptively hop on varying terrain in an energy-efficient yet agile manner. It can also detect obstacles through capacitive self-sensing. The leg performs powerful and agile gait motions beyond 5 Hz and high jumps up to 40 % of the leg height. Our leg’s tunable stiffness and inherent adaptability allow it to hop over grass, sand, gravel, pebbles, and large rocks using only open-loop force control. The electrohydraulic leg features a low cost of transport (0.73), and while squatting, it consumes only a fraction of the energy (1.2 %) compared to its conventional electromagnetic counterpart. Its agile, adaptive, and energy-efficient properties would open a roadmap toward a new class of musculoskeletal robots for versatile locomotion and operation in unstructured natural environments. Future bioinspired locomotion systems need design’s agility and adaptiveness. Here, the authors report a musculoskeletal leg design which leverages multi-layered electrohydraulic actuators to achieve highly energy-efficient and versatile motion.

Skin color varies among human populations and is thought to be under selection, with light skin maximizing vitamin D production at higher latitudes and dark skin providing UV protection in equatorial zones. To identify the genes that give rise to the palette of human skin tones, Crawford et al. applied genome-wide analyses across diverse African populations (see the Perspective by Tang and Barsh). Genetic variants were identified with likely function in skin phenotypes. Comparison to model organisms verified a conserved function of MFSD12 in pigmentation. A global genetic panel was used to trace how alleles associated with skin color likely moved across the globe as humans migrated, both within and out of Africa. Science , this issue p. eaan8433 ; see also p. 867 Genome-wide analysis of 2000 Africans identifies and functionally characterizes pigmentation loci. Despite the wide range of skin pigmentation in humans, little is known about its genetic basis in global populations. Examining ethnically diverse African genomes, we identify variants in or near SLC24A5 , MFSD12 , DDB1 , TMEM138 , OCA2 , and HERC2 that are significantly associated with skin pigmentation. Genetic evidence indicates that the light pigmentation variant at SLC24A5 was introduced into East Africa by gene flow from non-Africans. At all other loci, variants associated with dark pigmentation in Africans are identical by descent in South Asian and Australo-Melanesian populations. Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in mice, and that mutations in melanocyte-specific regulatory regions near DDB1/TMEM138 correlate with expression of ultraviolet response genes under selection in Eurasians.

Two early Late Pleistocene (~105,000- to 125,000-year-old) crania from Lingjing, Xuchang, China, exhibit a morphological mosaic with differences from and similarities to their western contemporaries. They share pan–Old World trends in encephalization and in supraorbital, neurocranial vault, and nuchal gracilization. They reflect eastern Eurasian ancestry in having low, sagittally flat, and inferiorly broad neurocrania. They share occipital (suprainiac and nuchal torus) and temporal labyrinthine (semicircular canal) morphology with the Neandertals. This morphological combination reflects Pleistocene human evolutionary patterns in general biology, as well as both regional continuity and interregional population dynamics.