Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
501,239
result(s) for
"Aging."
Sort by:
International handbook on ageing and public policy
This title explores the challenges arising from the ageing of populations across the globe for government, policy makers, the private sector and civil society.
BOOK
A Life Worth Hacking
Butter-infused coffee shakes, electromagnetic pulse belts for your dog, and a plethora of pills promising to do everything from tricking your stomach into thinking it's full to tricking your body into believing it's young-there was no shortage of offerings that felt, even to the most open-minded newcomer, like hokum at best or a pernicious hoax at worst. A struggling traditional healthcare system, an aging population in which older adults are projected to eclipse children in the next ten years, and a robust tech sector that finds all areas of human life ripe for disruption: these trends make for excellent conditions to encourage the building of machinery that addresses the most pressing biological challenges of the human species. \"If I didnt do what I just did in there,\" he replied, \"I wouldn't have been able to teach you anything at all.\" Because a body that cant relieve itself, he realized, also can't pray.
Journal Article
An aged immune system drives senescence and ageing of solid organs
Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly
1
,
2
. To define the contribution of immune system ageing to organism ageing, here we selectively deleted
Ercc1
, which encodes a crucial DNA repair protein
3
,
4
, in mouse haematopoietic cells to increase the burden of endogenous DNA damage and thereby senescence
5
–
7
in the immune system only. We show that
Vav-iCre
+/−
;Ercc1
−/fl
mice were healthy into adulthood, then displayed premature onset of immunosenescence characterized by attrition and senescence of specific immune cell populations and impaired immune function, similar to changes that occur during ageing in wild-type mice
8
–
10
. Notably, non-lymphoid organs also showed increased senescence and damage, which suggests that senescent, aged immune cells can promote systemic ageing. The transplantation of splenocytes from
Vav-iCre
+/−
;Ercc1
−/fl
or aged wild-type mice into young mice induced senescence
in
trans
, whereas the transplantation of young immune cells attenuated senescence. The treatment of
Vav-iCre
+/−
;Ercc1
−/fl
mice with rapamycin reduced markers of senescence in immune cells and improved immune function
11
,
12
. These data demonstrate that an aged, senescent immune system has a causal role in driving systemic ageing and therefore represents a key therapeutic target to extend healthy ageing.
An aged, senescent immune system has a causal role in driving systemic ageing, and the targeting of senescent immune cells with senolytic drugs has the potential to suppress morbidities associated with old age.
Journal Article
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ageing pathways and processes, and suggest that ageing research is entering a new era that has unique medical, commercial and societal implications. We argue that this era marks an inflection point, not only in ageing research but also for all biological research that affects the human healthspan.
The milestones that mark the advances in ageing research, the medical, commercial and societal implications of ageing and the different ageing pathways and processes that are associated with ageing are discussed.
Journal Article
Measuring biological aging in humans: A quest
The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple chronic diseases, leading to complex drug treatments and increased risk of physical and cognitive disability. Improving or preserving the health and quality of life of these individuals is challenging due to a lack of well‐established clinical guidelines. Physicians are often forced to engage in cycles of “trial and error” that are centered on palliative treatment of symptoms rather than the root cause, often resulting in dubious outcomes. Recently, geroscience challenged this view, proposing that the underlying biological mechanisms of aging are central to the global increase in susceptibility to disease and disability that occurs with aging. In fact, strong correlations have recently been revealed between health dimensions and phenotypes that are typical of aging, especially with autophagy, mitochondrial function, cellular senescence, and DNA methylation. Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging. Understanding how the underlying biological mechanisms of aging connect to and impact longitudinal changes in health trajectories offers a unique opportunity to identify resilience mechanisms, their dynamic changes, and their impact on stress responses. Harnessing how to evoke and control resilience mechanisms in individuals with successful aging could lead to writing a new chapter in human medicine.
Finding a reference metric for the rate of biological aging is key to understanding the molecular nature of the aging process. Defining and validating this metric in humans opens the door to a new kind of medicine that will overcome the limitation of current disease definitions. We will then be able to approach health in a global perspective and bring life course preventative measures to the center of attention.
Journal Article