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American Scream
Written as a cultural weapon and a call to arms,Howltouched a raw nerve in Cold War America and has been controversial from the day it was first read aloud nearly fifty years ago. This first full critical and historical study ofHowlbrilliantly elucidates the nexus of politics and literature in which it was written and gives striking new portraits of Allen Ginsberg, Jack Kerouac, and William Burroughs. Drawing from newly released psychiatric reports on Ginsberg, from interviews with his psychiatrist, Dr. Philip Hicks, and from the poet's journals,American Screamshows howHowlbrought Ginsberg and the world out of the closet of a repressive society. It also gives the first full accounting of the literary figures-Eliot, Rimbaud, and Whitman-who influencedHowl,definitively placing it in the tradition of twentieth-century American poetry for the first time. As he follows the genesis and the evolution ofHowl,Jonah Raskin constructs a vivid picture of a poet and an era. He illuminates the development of Beat poetry in New York and San Francisco in the 1950s--focusing on historic occasions such as the first reading ofHowlat Six Gallery in San Francisco in 1955 and the obscenity trial over the poem's publication. He looks closely at Ginsberg's life, including his relationships with his parents, friends, and mentors, while he was writing the poem and uses this material to illuminate the themes of madness, nakedness, and secrecy that pervadeHowl.A captivating look at the cultural climate of the Cold War and at a great American poet,American Screamfinally tells the full story ofHowl-a rousing manifesto for a generation and a classic of twentieth-century literature.
eBook
The ultimate Woody Allen film companion
\"A complete look at the extensive, ageless, unparalleled filmography of Woody Allen. Writer, actor, director, comedian, author, and musician, Woody Allen is one of the most culturally and cinematically influential filmmakers of all time. His films - he has over 45 writing and directing credits to his name - range from slapstick to tragedy, farce to fantasy. As one of history's most prolific moviemakers, his style and comic sensibility have been imitated, but never replicated, by countless other filmmakers over the years. In The Ultimate Woody Allen Film Companion, film writer Jason Bailey profiles every one of Allen's films: from his debut feature, What's Up, Tiger Lily, through slapstick classics such as Take the Money and Run and Sleeper; Academy Award-winning films such as Annie Hall and Hannah and Her Sisters; and recent gems such as Midnight in Paris and Blue Jasmine. Bailey also includes essays on the fascinating themes that color Allen's works, from death and Freud to music and New York City. Getting up close and personal with the actors and actresses that have brought the iconic films to life, this book's behind-the-scenes stories span the entire career of a man whose catalog has grown into a timeless cornerstone of American pop culture. Complete with full cast lists, production details, and full-color images and artwork, The Ultimate Woody Allen Film Companion is the ultimate, indispensable reference to one of cinema's most beloved and important figures\"-- Provided by publisher.
BOOK
Multimodal integration of neuroimaging, transcriptomics and single-cell analysis reveals molecular correlates linking osteoporosis to brain abnormalities
BackgroundOsteoporosis (OP) and cognitive decline are highly prevalent comorbidities; however, the molecular mechanisms linking them remain unclear. We adopted a multimodal integrative strategy combining neuroimaging, transcriptomics, single-cell analysis, and in vivo validation to elucidate potential mechanisms.MethodsFifty-six patients and fifty-three healthy controls underwent resting-state functional MRI (fMRI) to assess regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF). Transcriptomic data from the Allen Human Brain Atlas (AHBA), single-nucleus RNA sequencing (snRNA-seq) of the human hippocampus, and validation using ovariectomized (OVX) mouse models were integrated.ResultsfMRI revealed significant ALFF/ReHo alterations in the hippocampus, prefrontal cortex, and posterior cingulate cortex of OP patients, with the left hippocampal ALFF mediating the association between bone mineral density (BMD) and Montreal Cognitive Assessment (MoCA) scores. Spatial correlation analyses have linked these brain functional changes to neurotransmitter receptors (5-HT1a, D1, GABAa, etc.) and genes enriched in synaptic function, neurogenesis, and dopaminergic signaling. snRNA-seq identified the caudal hippocampus as a key region, with astrocytes enriched in OP-associated Gene Program 5 (involving NR4A3 and KCNIP1) and functional pathways such as glutamatergic synapses and calcium signaling. OVX mice showed bone loss, spatial learning/memory impairment, hippocampal astrocyte abnormalities, and upregulation of GFAP, RGS7, and RGS6 proteins.ConclusionOur multimodal study establishes a molecular framework for the bone-brain axis, highlighting astrocytes and synaptic signaling as potential targets for the dual protection of bone and brain health.
Journal Article
In the realm of tones : a composer's memoir
\"A poignant, compelling, and clear-eyed memoir of a life in music, with the dogged pursuit of composing at its center. Perhaps no art form has ever splintered into as many factions, genres, languages, philosophies, and mutually exclusive audiences as the art of music did in the mid-twentieth century. Allen Shawn's memoir fascinatingly evokes this tumultuous time, while weaving together his art and his life, hinting at their unexpected and sometimes paradoxical interconnections. Shawn grew up in an atmosphere of cultural privilege in New York City, the son of New Yorker editor William Shawn. An instinctive composing prodigy at age ten, it took him until the age of thirty to compose music he was proud of. Shawn sketches his childhood and long apprenticeship, his experiences composing for theater, dance, and concert hall, his forty years as a teacher at Bennington College, and his unexpected emergence as a writer. The book balances an account of his musical evolution, ups and downs, and life choices, offering glimpses into family life and of the many people with whom he interacted, including Leon Kirchner, Earl Kim, Nadia Boulanger, Pierre Petit, Jacques-Louis Monod, J. D. Salinger, John Updike, Benny Goodman, Louis Malle, and Vivian Fine. Along the way, Shawn offers reflections on such issues as social class, aging, loneliness, politics, and music education. In The Realm of Tones: A Composer's Memoir is a unique and touching account of one individual's internal search for self-expression and self-understanding, and of his effort to construct a life around it\"-- Provided by publisher.
BOOK
CONVERGENCE AND ERROR ANALYSIS FOR THE SCALAR AUXILIARY VARIABLE (SAV) SCHEMES TO GRADIENT FLOWS
We carry out convergence and error analysis of the scalar auxiliary variable (SAV) methods for L² and H⁻¹ gradient flows with a typical form of free energy. We first derive H² bounds, under certain assumptions suitable for both the gradient flows and the SAV schemes, which allow us to establish the convergence of the SAV schemes under mild conditions. We then derive error estimates with further regularity assumptions. We also discuss several other gradient flows, which cannot be cast in the general framework used in this paper, but for which convergence and error analysis can still be established using a similar procedure.
Journal Article
A New Class of Efficient and Robust Energy Stable Schemes for Gradient Flows
We propose a new numerical technique to deal with nonlinear terms in gradient flows. By introducing a scalar auxiliary variable (SAV), we construct efficient and robust energy stable schemes for a large class of gradient flows. The SAV approach is not restricted to specific forms of the nonlinear part of the free energy and only requires solving decoupled linear equations with constant coefficients. We use this technique to deal with several challenging applications which cannot be easily handled by existing approaches, and we present convincing numerical results to show that our schemes are not only much more efficient and easy to implement, but can also better capture the physical properties in these models. Based on this SAV approach, we can construct unconditionally second-order energy stable schemes, and we can easily construct even third- or fourth-order BDF schemes which, although not unconditionally stable, are very robust in practice. In particular, when coupled with an adaptive time stepping strategy, the SAV approach can be extremely efficient and accurate.
Journal Article