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Allergies
\"Describes what it is like to live with allergies, what its symptoms are, and how it is treated\"-- Provided by publisher.
Book
A handbook on allergic diseases
Allergies and allergic diseases can indeed affect multiple organs and systems in the body, leading to a wide range of symptoms and manifestations. By compiling insights from experts in different specialties, this book aims to support the medical literature and contribute to the collective knowledge on allergies. Although the causes and pathogenesis of allergic diseases in general are as described, this book is designed to be a guiding project by considering allergic diseases one by one and their causes, pathogenesis differences, and current treatments. A Handbook on Allergic Diseases serves as a valuable resource for healthcare professionals, researchers, and students interested in allergies and allergic diseases, offering a comprehensive overview of current knowledge and future directions in this important area of medicine.
eBook
Dixie wants an allergy
\"Dixie is jealous of the attention and sparkly bracelets her peers (who have allergies) get and so she sets out on a mission to find what she might be allergic to--with the warning to be careful what you wish for\"-- Provided by publisher.
Book
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
Purpose of Review
This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context of evolving knowledge over the last few decades.
Recent Findings
The prevalence of food allergy remains highest in early childhood with common food triggers being cow’s milk, soy, hen’s egg, wheat, peanut, tree nuts, sesame, fish, and shellfish. This correlates with certain risk factors especially pertinent in the postnatal period which appear to predispose an individual to developing a food allergy. Some allergies (such as milk and egg) were previously thought to be easily outgrown in early life; however, recent studies suggest increasing rates of persistence of these allergies into young adulthood; the reason behind this is unknown. Despite this, there is also evidence demonstrating that food allergies can be outgrown in adolescents and adults.
Summary
An understanding of the paradigm shifts in the natural history of food allergy allows clinicians to provide updated, age-appropriate, and tailored advice for patients on the management and prognosis of food allergy.
Journal Article
Allergic : our irritated bodies in a changing world
\"Hay fever. Peanut allergies. Eczema. Either you have a frustrating allergy, or you know someone who does. Billions of people worldwide-an estimated 30 to 40 percent of the global population-have some form of allergy; millions have one severe enough to actively endanger their health. Even more concerningly, over the last decade, the number of people diagnosed with allergy has been steadily increasing. Medical anthropologist Theresa MacPhail, herself an allergy sufferer whose father died of a bee sting, set out to understand why. This book is a holistic examination of the phenomenon of allergies from its first medical description in 1819 to the mind-bending recent development of biologics and immunotherapies that are giving the most severely impacted patients hope. In pursuit of this story, Theresa spent time with hundreds of experts, patients and activists: she scaled a roof with an air quality controller who diligently counts pollen by hand for hours every day; met a mother struggling to use WIC benefits for her daughter with severe food allergies; shadowed doctors at some of the finest allergy clinics in the world; and discussed the intersecting problems of climate change, pollution, and pollen with biologists who study seasonal respiratory allergies\"-- Provided by publisher.
Book
2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence supporting recommendations in the Guidelines, new information based on anaphylaxis publications from January 2014 through mid- 2015 is summarized. Advances in epidemiology, diagnosis, and management in healthcare and community settings are highlighted. Additionally, new information about patient factors that increase the risk of severe and/or fatal anaphylaxis and patient co-factors that amplify anaphylactic episodes is presented and new information about anaphylaxis triggers and confirmation of triggers to facilitate specific trigger avoidance and immunomodulation is reviewed. The update includes tables summarizing important advances in anaphylaxis research.
Journal Article
I'm allergic to milk
Milk allergies can develop in babies under a year old. Thereś good news: most kids dont́ have severe allergic reactions to milk products and many will eventually outgrow it. Readers learn the signs of a milk allergy and what kinds of food to avoid if they have such an allergy. Full-color images help draw readers into age-appropriate explanations and science information about an important subject theyĺl likely encounter in their own life or that of a friend.
Book
Belgian Case Series Identifies Non-Cow Mammalian Milk Allergy as a Rare, Severe, Selective, and Late-Onset Condition
Background: Cow’s milk allergy (CMA) is the most common food allergy in children, typically resolving by adolescence. In contrast, the clinical spectrum of allergies to non-cow mammalian milk and their patterns of IgE cross-reactivity are less well documented. Nutritional differences between various mammalian milks may also impact dietary management in milk-allergic patients. Objectives: To characterize clinical features, onset age, and IgE cross-reactivity patterns of non-cow mammalian milk allergies in adult patients seen at a tertiary allergy center, and to compare these findings with published cases. Methods: A retrospective analysis of patients included in the “Extended Laboratory Investigation for Rare Causes of Anaphylaxis study” with mammalian milk allergy was performed using clinical history, skin testing, and serum-specific IgE measurements. Cross-reactivity patterns were assessed in selected cases using immunoblotting, specific IgE inhibition, and basophil activation testing, and compared with published reports of non-cow mammalian milk allergy. Results: In our case series of 22 patients with mammalian milk allergy and 10 healthy control subjects, 3 patients were identified with isolated adult-onset non-cow mammalian milk allergy (n = 1 buffalo milk; n = 2 mare milk), confirmed via immunoblotting and basophil activation testing. Streptavidin-based specific IgE measurement for buffalo cheese was positive in the buffalo milk allergic patient. The literature review identified 82 cases of non-cow mammalian milk allergy. These cases typically showed late onset (mean age 8.6 years; range 1–70 years), severe reactions (CoFAR (Consortium for Food Allergy Research) grade 3 or 4 in 66%, and one fatality), and selective sensitization (affecting sheep and/or goat, camel, mare, buffalo, donkey, or combinations thereof in 56, 10, 5, 5, 4, and 2 cases, respectively). Conclusions: Non-cow mammalian milk allergies are rare but generally present later in life with selective IgE cross-reactivity, differing from the broader cross-reactivity observed in CMA. This selectivity may allow for safe dietary alternatives. These findings underscore the need for improved diagnostics and personalized dietary management in this patient population.
Journal Article
Y.sub.2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats
Purpose: [P.sub.2][Y.sub.2] receptors ([P.sub.2][Y.sub.2]Rs) are among the various receptors that play an important role in nociception. The goal of this research was to investigate possible [P.sub.2][Y.sub.2]R expression changes in the trigeminal ganglion (TRG) in bilateral masseter muscle (MM) hypersensitivity following unilateral MM inflammation. The impact of unilateral intramasseteric administration of [P.sub.2][Y.sub.2]R antagonist on bilateral MM hypersensitivity was also explored. Materials and Methods: Bilateral MM hypersensitivity was provoked by unilateral intramasseteric injection of complete Freund's adjuvant (CFA). The head withdrawal threshold (HWT) was assessed bilaterally 4 days later. Bilateral TRG and MM isolation were followed, and quantitative real-time polymerase chain reaction (qRT-PCR) and histopathological analysis were carried out on these tissues, respectively. The involvement of [P.sub.2][Y.sub.2]Rs in nocifensive behavior was evaluated by administering two doses of [P.sub.2][Y.sub.2]R antagonist AR-C118925 (0.2 or 1 mg/100 [micro]L) in inflamed MM 4 days post-CFA administration. Bilateral HWT was assessed at different time points following antagonist injection. Results: qRT-PCR analysis demonstrated [P.sub.2][Y.sub.2]R up-regulation in TRG ipsilateral to the site of CFA administration. Compared to the controls, both doses of AR-C118925 injected ipsilateral to the TRG increased the bilateral HWT at 30, 60, 90, and 120 minutes after antagonist administration. Conclusion: The findings suggest that [P.sub.2][Y.sub.2]Rs may affect MM inflammatory hypersensitivity owing to its up-regulation in the TRG in MM inflammatory pain states. Keywords: facial pain, masticatory muscles, temporomandibular disorders, trigeminal ganglion
Journal Article