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How the War on Drugs is maintained through racism,authority and public opinion.  From the hit television series Breaking Bad , to daily news reports, anti-drug advertising campaigns and  highly publicized world-wide hunts for “narcoterrorists” such as Joaquin “El Chapo” Guzman, the drug, methamphetamine occupies a unique and important space in the public’s imagination.  In Meth Wars , Travis Linnemann situates the meth epidemic within the broader culture and politics of drug control and mass incarceration. Linnemann draws together a range of examples and critical interdisciplinary scholarship to show how methamphetamine, and the drug war more generally, are part of a larger governing strategy that animates the politics of fear and insecurity and links seemingly unrelated concerns such as environmental dangers, the politics of immigration and national security, policing tactics, and terrorism.  The author’s unique analysis presents a compelling case for how the supposed “meth epidemic” allows politicians, small town police and government counter-narcotics agents to engage in a singular policing project in service to the broader economic and geostrategic interests of the United States.

Meth cooks practice late industrial alchemy-transforming base materials, like lithium batteries and camping fuel, into gold Meth alchemists all over the United States tap the occulted potencies of industrial chemical and big pharma products to try to cure the ills of precarious living: underemployment, insecurity, and the feeling of idleness. Meth fires up your attention and makes repetitive tasks pleasurable, whether it's factory work or tinkering at home. Users are awake for days and feel exuberant and invincible. In one person's words, they \"get more life.\" The Alchemy of Meth is a nonfiction storybook about St. Jude County, Missouri, a place in decomposition, where the toxic inheritance of deindustrialization meets the violent hope of this drug-making cottage industry. Jason Pine bases the book on fieldwork among meth cooks, recovery professionals, pastors, public defenders, narcotics agents, and pharmaceutical executives. Here, St. Jude is not reduced to its meth problem but Pine looks at meth through materials, landscapes, and institutions: the sprawling context that makes methlabs possible.The Alchemy of Meth connects DIY methlabs to big pharma's superlabs, illicit speed to the legalized speed sold as ADHD medication, uniquely implicating the author's own story in the narrative. By the end of the book, the backdrop of St. Jude becomes the foreground. It could be a story about life and workanywhere in the United States, where it seems no one is truly clean and all are complicit in the exploitation of their precious resources in exchange for a livable present-or even the hope of a future.

Digital interventions can help to overcome barriers to care, including stigma, geographical distance, and a lack of culturally appropriate treatment options. \"We Can Do This\" is a web-based app that was designed with input from cultural advisors and end users to support Aboriginal and Torres Strait Islander people seeking to stop or reduce their use of methamphetamine and increase psychosocial well-being. This study aimed to evaluate the effectiveness of the \"We Can Do This\" web-based app as a psychosocial treatment for Aboriginal and Torres Strait Islander people who use methamphetamine. The web app was evaluated using a randomized waitlist controlled parallel group trial. Participants were Aboriginal and Torres Strait Islander people aged 16 years or older who self-identified as having used methamphetamine at least weekly for the past 3 months. Participants were randomized on a 1:1 ratio to receive either access to the web-based app for 6 weeks or a waitlist control group. Both groups received access to a website with harm minimization information. The primary outcome was days of methamphetamine use in the past 4 weeks assessed at 1, 2, and 3 months post randomization. Secondary outcomes included severity of methamphetamine dependence (Severity of Dependence Scale [SDS]), psychological distress (Kessler 10 [K10]), help-seeking behavior, and days spent out of role due to methamphetamine use. Participants (N=210) were randomized to receive either access to the web-based app (n=115) or the waitlist control condition (n=95). Follow-up was 63% at 1 month, 57% at 2 months, and 54% at 3 months. There were no significant group differences in days of methamphetamine use in the past 4 weeks at 1 the month (mean difference 0.2 days, 95% CI -1.5 to -2), 2 months (mean difference 0.6 days, 95% CI -1 to 2.4 days) or 3 months (mean difference 1.4 days, 95% CI -0.3 to 3.3 days) follow-up. There were no significant group differences in K10 scores, SDS scores, days out of role, or help-seeking at any of the 3 follow-up timepoints. There was poor adherence to the web-based app, only 20% of participants in the intervention group returned to the web-based app after their initial log-in. Participants cited personal issues and forgetting about the web-based app as the most common reasons for nonadherence. We found poor engagement with this web-based app. The web-based app had no significant effects on methamphetamine use or psychosocial well-being. Poor adherence and low follow-up hindered our ability to accurately evaluate the effectiveness of the web-based app. Future web-based apps for this population need to consider methods to increase participant engagement. Australian New Zealand Clinical Trials Registry ACTRN12619000134123p; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376088. RR2-10.2196/14084.

Methamphetamine: A Love Story presents an insider's view of the world of methamphetamine based on the life stories of thirty-three adults formerly immersed in using, dealing, and manufacturing meth in rural Oklahoma. Using a respectful tone towards her subjects, Shukla illuminates their often decades-long love affair with the drug, the attractions of the lifestyle, the eventual unsustainability of it, and the challenges of exiting the life. These personal stories reveal how and why people with limited economic means and inadequate resources become entrapped in the drug epidemic, while challenging longstanding societal views about addiction, drugs, drug policy, and public health.

Rationale and objectives Addiction to psychostimulant methamphetamine (METH) remains a major public health problem in the world. Animal models that use METH self-administration incorporate many features of human drug-taking behavior and are very helpful in elucidating mechanisms underlying METH addiction. These models are also helping to decipher the neurobiological substrates of associated neuropsychiatric complications. This review summarizes our work on the influence of METH self-administration on dopamine systems, transcription and immune responses in the brain. Methods We used the rat model of METH self-administration with extended access (15 h/day for eight consecutive days) to investigate the effects of voluntary METH intake on the markers of dopamine system integrity and changes in gene expression observed in the brain at 2 h–1 month after cessation of drug exposure. Results Extended access to METH self-administration caused changes in the rat brain that are consistent with clinical findings reported in neuroimaging and postmortem studies of human METH addicts. In addition, gene expression studies using striatal tissues from METH self-administering rats revealed increased expression of genes involved in cAMP response element binding protein (CREB) signaling pathway and in the activation of neuroinflammatory response in the brain. Conclusion These data show an association of METH exposure with activation of neuroplastic and neuroinflammatory cascades in the brain. The neuroplastic changes may be involved in promoting METH addiction. Neuroinflammatory processes in the striatum may underlie cognitive deficits, depression, and parkinsonism reported in METH addicts. Therapeutic approaches that include suppression of neuroinflammation may be beneficial to addicted patients.

Previous studies both in laboratory animals and humans have reported that abstinence induces incubation of cue-induced drug craving for nicotine, alcohol, cocaine, and methamphetamine. However, current experimental procedures utilized to study incubation of methamphetamine craving do not incorporate the temporal dynamics of neuropsychological measures and electrophysiological activities associated with this incubation process. This study utilized the high-density electroencephalogram (EEG) signals as a rapid, inexpensive, and noninvasive measure of cue-induced craving potential. A total of 156 male individuals with methamphetamine use disorder (MUD) enrolled in this multisite, cross-sectional study. Structured clinical interview data, self-report questionnaires (cued craving, quality of sleep, impulsivity, anxiety, and depression) and resting-state, eye-closed 128 high-density channel EEG signals were collected at 5 abstinence duration time points (<1, 1–3, 3–6, 6–12, and 12–24 months) to track the neuropsychological and neurophysiological signatures. Cue-induced craving was higher after 1–3 months than after the other time points. This incubation effect was also observed for sleep quality but not for anxiety, depression, and impulsivity symptoms, along with exhibited decreased power spectrum for theta (5.5–8 Hz) and alpha (8–13 Hz), and increased in beta (16.5–26.5 Hz) frequency band. Source reconstructed resting-state EEG analysis showed increased synchronization of medial prefrontal cortex (MPFC) for the beta frequency band in 1–3 months abstinent MUD group, and associated with the incubation of craving. Remarkably, the robust incubation-related abnormalities may be driven by beta-band source space connectivity between MPFC and bilateral orbital gyrus (ORB). Our findings suggest the enhancement of beta activity in the incubation period most likely originates from a dysfunction involving frontal brain regions. This neurophysiological signature of incubation of craving can be used to identify individuals who might be most susceptible to relapse, providing a potential insight into future therapeutic interventions for MUD via neuromodulation of beta activity.

Methamphetamine (METH) abuse is associated with addiction, emotional dysregulation, motor impairments, cognitive deficits, and depressive symptoms, which are exacerbated by stress and social isolation. This study investigated the therapeutic potential of combined treatment and environmental enrichment in METH withdrawn mice. Behavioral, biochemical and neurochemical outcomes were evaluated. Post-treatment results demonstrated: motor and exploratory behavior via OFT (open field test) mobility increased to from 32.37 meters (withdrawal group) to 59.52 meters, anxiety reduction indicated in EPM (elevated plus maze test) open arm rose from 33.2 to 74.2 sec, while cognitive improvement by MWM (morris water maze test) escape latency decreased from 225.4 to 127.4 sec in hidden platform trial. Moreover, memory and exploration activity were determined by NOR (novel object recognition test) and HBT (hole board test) which showed enhanced novel object exploration (16.4 vs 5 sec) and exploratory behavior (17.6 explored areas vs 8.6). Social interaction time increased to 41.64 sec, and light-dark compartment preference improved to 68.4%. Biochemical analysis revealed elevated antioxidants enzymes activity POD (peroxidase) (0.178 U/min) SOD (superoxide dismutase) (0.82 U/mg protein) and CAT (catalase) (3.6 U/min) indicating improved oxidative stress resilience. Neurotransmitters restoration was observed with serotonin (0.21 µg/mg) and dopamine (0.46 µg/mg) levels rebounding from negligible withdrawn group. These findings demonstrate that combined treatment and enriched environment robustly accelerate functional recovery in METH-withdrawn mice, suggesting a promising strategy for mitigating addiction-related deficits.

Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA) function might recover with protracted detoxification. However, the extent to which striatal DA function in METH predicts recovery has not been evaluated. Here we assessed whether striatal DA activity in METH abusers is associated with clinical outcomes. Brain DA D2 receptor (D2R) availability was measured with positron emission tomography and [ 11 C]raclopride in 16 METH abusers, both after placebo and after challenge with 60 mg oral methylphenidate (MPH) (to measure DA release) to assess whether it predicted clinical outcomes. For this purpose, METH abusers were tested within 6 months of last METH use and then followed up for 9 months of abstinence. In parallel, 15 healthy controls were tested. METH abusers had lower D2R availability in caudate than in controls. Both METH abusers and controls showed decreased striatal D2R availability after MPH and these decreases were smaller in METH than in controls in left putamen. The six METH abusers who relapsed during the follow-up period had lower D2R availability in dorsal striatum than in controls, and had no D2R changes after MPH challenge. The 10 METH abusers who completed detoxification did not differ from controls neither in striatal D2R availability nor in MPH-induced striatal DA changes. These results provide preliminary evidence that low striatal DA function in METH abusers is associated with a greater likelihood of relapse during treatment. Detection of the extent of DA dysfunction may be helpful in predicting therapeutic outcomes.