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"Analytical biochemistry Textbooks."
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Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology
The discovery of a new neurotransmitter, especially one in the central nervous system, is both important and difficult. We have been searching for new neurotransmitters for 12 y. We detected creatine (Cr) in synaptic vesicles (SVs) at a level lower than glutamate and gamma-aminobutyric acid but higher than acetylcholine and 5-hydroxytryptamine. SV Cr was reduced in mice lacking either arginine:glycine amidinotransferase (a Cr synthetase) or SLC6A8, a Cr transporter with mutations among the most common causes of intellectual disability in men. Calcium-dependent release of Cr was detected after stimulation in brain slices. Cr release was reduced in Slc6a8 and Agat mutants. Cr inhibited neocortical pyramidal neurons. SLC6A8 was necessary for Cr uptake into synaptosomes. Cr was found by us to be taken up into SVs in an ATP-dependent manner. Our biochemical, chemical, genetic, and electrophysiological results are consistent with the possibility of Cr as a neurotransmitter, though not yet reaching the level of proof for the now classic transmitters. Our novel approach to discover neurotransmitters is to begin with analysis of contents in SVs before defining their function and physiology.
Journal Article
Benefits of electrochemistry studies for the majority of students who will not become electrochemists
In teaching electrochemistry, it is of primary importance to make students always aware of the relations between electrochemistry and all the non-electrochemical topics, which are taught. The vast majority of students will not specialise in electrochemistry, but they all can very much benefit from the basics and concepts of electrochemistry. This paper is aimed to give suggestions how the teaching of electrochemistry can easily be interrelated to topics of inorganic, organic, analytical, environmental chemistry, biochemistry and biotechnology.
Journal Article
Use of primary literature in the undergraduate analytical class
Issue Title: Comprehensive peptide marker identification/Data independent acquisition-digital archiving mass spectrometry/Insights into mechanisms of sublimed DHB matrix in ME-SIMS/Phenylbutazone purity challenge
Journal Article
Teaching analytical chemistry in China: past, present, and future perspectives
While there are references to the practice of chemical analysis in ancient Chinese times, the modern system of analytical chemistry was introduced into China in the late 19th century. Thanks to the Chinese chemist Shou Xu, who translated several chemical books from western countries, including two important books on analytical chemistry: Manual of Qualitative Chemical Analysis [1] and Quantitative Chemical Analysis [2]. The Chinese titles of the translated books were HUAXUE KAOZHI and HUAXUE QIUSHU. These two books, together with other books translated later by Chinese scientists, became the key textbooks for chemical analysis. For a long time, however, all textbooks related to the analytical chemistry in China were translated from western countries.
Journal Article
The pycnometer challenge
Issue Title: Trends and Critical Reviews/Mass spectrometry for the characterization of nanoparticles/Optical tweezers for medical diagnostics/Metrology for metalloproteins
Journal Article
Gaming stereochemistry
R/S Chemistry is a free, game-based learning tool for students to practise stereochemical assignments in an interactive setting, leading to increased student engagement in the topic.
Journal Article
Redefining the mole: the perspective of teaching and learning
This commentary draws on the perspective of teaching and learning to discuss the issue of redefining the mole.
Journal Article