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Cancer Genetics in the Arab World
Cancer remains a major global health burden, with incidence rates rising globally. The Arab world, which is often regarded as an underrepresented population in literature, shows distinct patterns in cancer incidences, genetics, and outcomes in comparison with Western populations. This review aims to highlight key genomic studies conducted in the Arab world. We describe the epidemiological and genetic landscape of cancer in the Arab populations, focusing on lung, breast, and colorectal cancers, given their prominence and distinctive patterns in the region. We utilised data from GLOBOCAN 2022 and published genomic studies to assess subregional incidence trends, identify significant mutations, and explore hereditary and early-onset cancers profiles. Breast, lung, and colorectal cancers dominate the cancer profile in the region, with disparities in genetic alterations when compared to global trends. Variation in EGFR mutation frequencies in lung cancer across diverse ethnicities in the MENA region is representative of the extreme heterogeneity in the Arab region. Variations in BRCA1/2 mutation frequency, and unique founder mutations highlight breast cancer's particular regional genetic traits. Similarly, colorectal cancer studies show variations in mutational profiles, such as a low incidence of BRAF mutations and distinct epigenetic characteristics that represent region-specific disease pathways. Early-onset cancers, particularly breast and colorectal cancers, occur at higher rates than in Western populations and often diverge from the typical germline mutation patterns reported globally. The review emphasises the importance of conducting localised genetic studies in improving personalised medicine and public health strategies. Despite these efforts, significant gaps remain, particularly in understanding early-onset cancers and hereditary cancer genetic disorders, which are overrepresented in the region. Further research on the genetic basis of cancer in Arab populations is essential for advancing personalised treatment and improving cancer outcomes in these under-researched groups.
Journal Article
Library and information science research in the Arab World: a bibliometric analysis 1951–2021
Purpose>This study aims to investigate the research productivity of library and information science (LIS) authors affiliated with the 22 countries of the Arab League. It also identifies the top countries, organizations, authors, journals, natures of collaboration, and frequently used keywords in LIS research in the Arab world.Design/methodology/approach>Bibliometric methods were used to evaluate the research performance of the authors affiliated with library organizations in the Arab region. The Elsevier Scopus database was selected for data retrieval. A comprehensive search strategy was adopted to retrieve 863 publications contributed by LIS authors affiliated with the Arab countries. VOS viewer, Biblioshiny, BiblioAnalyitics, Microsoft Access and Microsoft Excel were used for data visualization and analysis.Findings>This paper presents the dynamics and the state of the LIS research in the Arab region published between 1951 and 2021. The results of the study have highlighted an upward trend in the growth of the publications, especially in the past four years. The largest number of studies were published in the year 2020. The country-wise analysis ranked Kuwait and Saudi Arabia as the top LIS research producing countries with five and four researchers, respectively. The Kuwait University, the King Fahd University of Petroleum and Minerals and the Imam Abdulrahman Bin Faisal University were the three most productive organizations. Academic libraries, social media, bibliometrics, information-seeking behavior, information literacy and knowledge management were identified as the major areas of interest for the researchers. Internet and open access were topics that had gained recent popularity, while the digital library, research data management, green librarianship, link data, cloud computing, library leadership, library automation and artificial intelligence were identified as areas requiring further attention. Furthermore, the single-author pattern was found to be the most preferred pattern.Practical implications>The findings of this study would help prospective researchers in choosing the neglected areas of research that require further investigation. They would also help policymakers in identifying factors that need more attention and allocation of research funds.Originality/value>To the best of the authors’ knowledge, this is the first comprehensive bibliometric study that presents a holistic picture of the LIS research in the Arab region.
Journal Article
Psychosocial family interventions for relatives of people living with psychotic disorders in the Arab world: systematic review
Background
Family interventions in schizophrenia are evidence based and have been adapted to different cultural settings to improve their effectiveness and acceptability. The Arab world has a unique set of socio-cultural norms and values that cannot be ignored when developing or implementing such interventions. There is a lack of research on the feasibility of delivering family interventions for schizophrenia in the Arab region. The aim of this review is to synthesise the available evidence about culturally-adapted psychosocial family interventions in the Arab world. The review identifies the content and characteristics of these interventions, determines the strategies used to adapt them to Arab culture successfully, assesses the feasibility and acceptability of the interventions, and evaluates the effectiveness of these interventions for service users and their families.
Method
Five electronic databases were searched including MEDLINE, CINAHL, Cochrane Library, PsycINFO and EMBASE for articles written in Arabic and English from inception to August 2019. Data were extracted and synthesised narratively.
Results
Six studies were retrieved from the search: three randomised control studies, two non-randomised studies and one qualitative study. There is limited evidence about culturally-adapted family interventions in the Arab region. However, the cultural adaptation process was comprehensive, and the implementation was reported to be feasible and acceptable. The methodological quality of the included studies was generally poor, so there is a risk of underestimating the effect size of the interventions due to lack of rigour and the presence of bias.
Conclusion
The present review provides the foundation for future work regarding family interventions in the Arab world, and confirms the feasibility of implementing such interventions with some modifications. Furthermore, the data suggests that any family-oriented intervention for schizophrenia is likely to be better than standard care in improving the outcome for patients and their families.
Journal Article
Colonialism, Postcolonialism, Globalization, and Arab Culture
This article will address two major related issues regarding Arab culture as an integral part of the globalization ethos. In order to expand the conceptual parameters of globalization and cultural studies, the exclusivity of political and economic globalization will be interrogated in favor of a more diverse, humanitarian definition of the term. At the heart of this argument, inflected by interdisciplinarity and the literature and theory of postcolonial studies, is tolerance, respect, and recognition of difference and for the marginalized voices of the “other.” The theoretical framework challenges the stereotyping, homogenization, and misrepresentation of Arabs, colonialist ideas that have been carried over into the practice of globalism and the marginalization of Arab history and culture within world heritage. It is my hope to correct the negative perceptions about the Arab people, mainstream misperceptions of politicians, the media, and public discourse. The article will underscore the diversity and complexity of the identity and history of people in the Middle East and North Africa. Although in the West Arabs are usually synonymous with Muslims, a discussion of Islam and/or Islamophobia will not be addressed in this article. The first part will elaborate on the historical context of the creation of the modern Arab world. Next, various definitions of the main domains of globalism and their correlation to the contemporary Arab world will be summarized. Integrated into both sections are two major issues: the creative resistance that has accompanied the founding of the modern Arab world and the impact of globalization on Arab society, concepts that have played out in the containment of this region.
Journal Article
Mapping environmental impact assessment research landscapes in the Arab world using visualization and bibliometric techniques
Interests and concerns on environmental issues have attracted much attention over the past few decades. This is in harmony with the growing understanding of environmental impacts associated with human activities and their role in degrading ecosystems. In line with these concerns, considerable advances in science and technology to assess, mitigate, or lessen these adverse impacts have emerged (i.e., environmental impact assessment (EIA) methodologies). The involvement of EIA in sustainable development has become a prevalent topic in research in either developed and developing countries. The present work investigated the research status, development trends, and hotspots of EIA in a region with massive environmental challenges; the Arab world. Bibliometric analysis and visualization mapping were utilized with an objective of revealing and evaluating the developments in knowledge on EIA from the Arab world. A sum of 595 documents was the productivity of the Arab world on EIA (2.1% of total global productivity). Most of the studies were performed by scholars in Egypt (143 documents; 24.0%), followed by Saudi Arabia (96 documents; 16.1%), and Tunisia (68 documents; 11.4%). France, the USA, and the UK were, respectively, the most collaborated countries with the Arab world on EIA. Most of the publications on EIA were in prestigious journals in relation to environmental sciences.
King Abdulaziz University
, Saudi Arabia and
University of Kuwait
were the most productive institutions (24 documents/institution). Topics in relation to assessing different environmental impacts on the quality and quantity of water will continue to be vital themes of research. While, the utilization of remote sensing, geographic information systems, risk assessment, life cycle assessment, bioaccumulation, and biomarkers techniques in assessing environmental impacts will continue to be dominant as efficient tools in conducting EIA related research. The outcomes displayed, in general, a rapidly and steadily rising interests on EIA. However, the development of regional experience, increasing of funds and advancing of competencies will further promote research activities on EIA.
Journal Article