Explore the vast range of titles available.

\"Introduces the reader to what happens when someone breaks a bone and how it is treated and cared for\"-- Provided by publisher.

Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinically relevant, and lasting motor recovery in chronic stroke survivors more effectively than sham FES. Such recovery is associated to quantitative signatures of functional neuroplasticity. BCI patients exhibit a significant functional recovery after the intervention, which remains 6–12 months after the end of therapy. Electroencephalography analysis pinpoints significant differences in favor of the BCI group, mainly consisting in an increase in functional connectivity between motor areas in the affected hemisphere. This increase is significantly correlated with functional improvement. Results illustrate how a BCI–FES therapy can drive significant functional recovery and purposeful plasticity thanks to contingent activation of body natural efferent and afferent pathways. Brain-computer interface (BCI) can improve motor skills on stroke patients. This study shows that BCI-controlled neuromuscular electrical stimulation therapy can cause cortical reorganization due to activation of efferent and afferent pathways, and this effect can be long lasting in a brain region specific manner.

After a variable SOA a peripheral target appeared and participants were asked either to touch it if it was a real word (go-trials) or to stay still if it was a pseudo-word (no-go trials; see Methods for more details). After a variable delay (stimulus onset asynchrony; SOA) a peripheral target appeared and participants were asked either to touch it, if it was printed in green (go-trials) or to stay still if it was printed in red (no-go trials; see Methods for more details). https://doi.org/10.1371/journal.pone.0104349.g002 1.

This book assesses how progress in disarmament diplomacy in the last decade has improved human security. In doing so, the book looks at three cases of the development of international norms in this arena. First, it traces how new international normative understandings have shaped the evolution of and support for an Arms Trade Treaty (the supply side of the arms trade); and, second, it examines the small arms international regime and examines a multilateral initiative that aims to address the demand side (by the Geneva Declaration); and, third, it examines the evolution of two processes to ban and regulate cluster munitions. The formation of international norms in these areas is a remarkable development, as it means that a domain that was previously thought to be the exclusive purview of states, i.e. how they procure and manage arms, has been penetrated by multiple influences from worldwide civil society. As a result, norms and treaties are being established to address the domain of arms, and states will have more multilateral restriction over their arms and less sovereignty in this domain. This book will be of much interest to students of the arms trade, international security, international law, human security and IR in general. Denise Garcia is Assistant Professor in the Department of Political Science at Northeastern University, Boston. She is author of Small Arms and Security (Routledge 2006). Denise Garcia is Assistant Professor in the Department of Political Science at Northeastern University, Boston. She is author of Small Arms and Security (Routledge 2006). Introduction 1. Norms: Progress and Evolution in the Conduct of International Affairs 2. The Arms Trade Treaty 3. Small Arms and Light Weapons Regimes and the Geneva Declaration on Armed Violence 4. Banning Cluster Munitions. Conclusion

Purpose To prospectively assess the efficacy of the lymphatic microsurgical preventive healing approach (LYMPHA) to prevent lymphedema after axillary dissection (AD) for breast cancer treatment. Methods Among 49 consecutive women referred from March 2008 to September 2009 to undergo complete AD, 46 were randomly divided in 2 groups. Twenty-three underwent the LYMPHA technique for the prevention of arm lymphedema. The other 23 patients had no preventive surgical approach (control group). The LYMPHA procedure consisted of performing lymphatic-venous anastomoses (LVA) at the time of AD. All patients underwent preoperative lymphoscintigraphy (LS). Patients were followed up clinically at 1, 3, 6, 12, and 18 months by volumetry. Postoperatively, LS was performed after 18 months in 41 patients (21 treatment group and 20 control group). Arm volume and LS alterations were assessed. Results Lymphedema appeared in 1 patient in the treatment group 6 months after surgery (4.34%). In the control group, lymphedema occurred in 7 patients (30.43%). No statistically significant differences in the arm volume were observed in the treatment group during follow-up, while the arm volume in the control group showed a significant increase after 1, 3, and 6 months from operation. There was significant difference between the 2 groups in the volume changes with respect to baseline after 1, 3, 6, 12, and 18 months after surgery (every timing P value < 0.01). Conclusions LYMPHA represents a valid technique for primary prevention of secondary arm lymphedema with no risk of leaving undetected malignant disease in the axilla.

Hand–arm vibration syndrome (HAVS) is caused by long-term exposure to hand-transmitted vibration (HTV), and its pathogenesis has not been elucidated fully. We explored the molecular mechanism of HAVS and provided clues and a theoretical basis for the early prevention and treatment of HAVS. After vibration, samples were collected from the plasma of human workers, plasma of rat tails, and human umbilical vein endothelial cells (HUVECs). ELISAs were used to measure the expression of vasoactive factors. Cell Counting Kit-8 and electron microscopy were used to detect cell damage. Flow cytometry was employed to detect apoptosis. Real-time reverse transcription-polymerase chain reaction was used to measure the expression of long non-coding RNAs (lncRNAs). Western blotting was used to measure the expression of apoptosis-related proteins. Vibration could cause cell damage, apoptosis, and changes in the expression vasoactive factors and lncRNAs. The lncRNA maternally expressed gene 3 ( MEG3 ) had a significant regulatory effect on cell damage, apoptotic proteins, and vascular regulatory factors in the HUVEC damage induced by vibration, as shown by the further decrease in viability and aggravation of injury after knockdown of MEG3 expression in HUVECs treated with vibration. Expression of vasoactive factors and apoptosis-related proteins was changed after interfering with MEG3 expression. In conclusion, vibration can affect the expression of vasoactive factors and lncRNA, and cause damage to vascular endothelial cells. MEG3 may be involved in the inflammatory damage to vascular endothelial cells induced by vibration.

[ Barriers to Bioweapons ] is a must-read for nonproliferation experts and should be a standard text for understanding biological weapons development for some time to come. ―David W. Kearn, Perspectives on Politics In both the popular imagination and among lawmakers and national security experts, there exists the belief that with sufficient motivation and material resources, states or terrorist groups can produce bioweapons easily, cheaply, and successfully. In Barriers to Bioweapons , Sonia Ben Ouagrham-Gormley challenges this perception by showing that bioweapons development is a difficult, protracted, and expensive endeavor, rarely achieving the expected results whatever the magnitude of investment. Her findings are based on extensive interviews she conducted with former U.S. and Soviet-era bioweapons scientists and on careful analysis of archival data and other historical documents related to various state and terrorist bioweapons programs. Bioweapons development relies on living organisms that are sensitive to their environment and handling conditions, and therefore behave unpredictably. These features place a greater premium on specialized knowledge. Ben Ouagrham-Gormley posits that lack of access to such intellectual capital constitutes the greatest barrier to the making of bioweapons. She integrates theories drawn from economics, the sociology of science, organization, and management with her empirical research. The resulting theoretical framework rests on the idea that the pace and success of a bioweapons development program can be measured by its ability to ensure the creation and transfer of scientific and technical knowledge. The specific organizational, managerial, social, political, and economic conditions necessary for success are difficult to achieve, particularly in covert programs where the need to prevent detection imposes managerial and organizational conditions that conflict with knowledge production. In both the popular imagination and among lawmakers and national security experts, there exists the belief that with sufficient motivation and material resources, states or terrorist groups can produce bioweapons easily, cheaply, and successfully. In Barriers to Bioweapons , Sonia Ben Ouagrham-Gormley challenges this perception by showing that bioweapons development is a difficult, protracted, and expensive endeavor, rarely achieving the expected results whatever the magnitude of investment. Her findings are based on extensive interviews she conducted with former U.S. and Soviet-era bioweapons scientists and on careful analysis of archival data and other historical documents related to various state and terrorist bioweapons programs.Bioweapons development relies on living organisms that are sensitive to their environment and handling conditions, and therefore behave unpredictably. These features place a greater premium on specialized knowledge. Ben Ouagrham-Gormley posits that lack of access to such intellectual capital constitutes the greatest barrier to the making of bioweapons. She integrates theories drawn from economics, the sociology of science, organization, and management with her empirical research. The resulting theoretical framework rests on the idea that the pace and success of a bioweapons development program can be measured by its ability to ensure the creation and transfer of scientific and technical knowledge. The specific organizational, managerial, social, political, and economic conditions necessary for success are difficult to achieve, particularly in covert programs where the need to prevent detection imposes managerial and organizational conditions that conflict with knowledge production.