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Artificial intelligence (AI) is being increasingly integrated into scientific discovery to augment and accelerate research, helping scientists to generate hypotheses, design experiments, collect and interpret large datasets, and gain insights that might not have been possible using traditional scientific methods alone. Here we examine breakthroughs over the past decade that include self-supervised learning, which allows models to be trained on vast amounts of unlabelled data, and geometric deep learning, which leverages knowledge about the structure of scientific data to enhance model accuracy and efficiency. Generative AI methods can create designs, such as small-molecule drugs and proteins, by analysing diverse data modalities, including images and sequences. We discuss how these methods can help scientists throughout the scientific process and the central issues that remain despite such advances. Both developers and users of AI tools need a better understanding of when such approaches need improvement, and challenges posed by poor data quality and stewardship remain. These issues cut across scientific disciplines and require developing foundational algorithmic approaches that can contribute to scientific understanding or acquire it autonomously, making them critical areas of focus for AI innovation. The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.

At least four articles credit the AI tool as a co-author, as publishers scramble to regulate its use. At least four articles credit the AI tool as a co-author, as publishers scramble to regulate its use. Credit: Iryna Imago/Shutterstock Hands typing on a laptop keyboard with screen showing artificial intelligence chatbot ChatGPT

Scientists are enthusiastically imagining ways in which artificial intelligence (AI) tools might improve research. Why are AI tools so attractive and what are the risks of implementing them across the research pipeline? Here we develop a taxonomy of scientists’ visions for AI, observing that their appeal comes from promises to improve productivity and objectivity by overcoming human shortcomings. But proposed AI solutions can also exploit our cognitive limitations, making us vulnerable to illusions of understanding in which we believe we understand more about the world than we actually do. Such illusions obscure the scientific community’s ability to see the formation of scientific monocultures, in which some types of methods, questions and viewpoints come to dominate alternative approaches, making science less innovative and more vulnerable to errors. The proliferation of AI tools in science risks introducing a phase of scientific enquiry in which we produce more but understand less. By analysing the appeal of these tools, we provide a framework for advancing discussions of responsible knowledge production in the age of AI. The proliferation of artificial intelligence tools in scientific research risks creating illusions of understanding, where scientists believe they understand more about the world than they actually do.

As researchers dive into the brave new world of advanced AI chatbots, publishers need to acknowledge their legitimate uses and lay down clear guidelines to avoid abuse. As researchers dive into the brave new world of advanced AI chatbots, publishers need to acknowledge their legitimate uses and lay down clear guidelines to avoid abuse. Credit: Tada Images/Shutterstock Webpage of ChatGPT, a prototype AI chatbot, is seen on the website of OpenAI, on a smartphone

Guided by brain-like ‘spiking’ computational frameworks, neuromorphic computing—brain-inspired computing for machine intelligence—promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for biological neural routines, but has evolved to encompass the hardware implementation of algorithms with spike-based encoding and event-driven representations. Here we provide an overview of the developments in neuromorphic computing for both algorithms and hardware and highlight the fundamentals of learning and hardware frameworks. We discuss the main challenges and the future prospects of neuromorphic computing, with emphasis on algorithm–hardware codesign. The authors review the advantages and future prospects of neuromorphic computing, a multidisciplinary engineering concept for energy-efficient artificial intelligence with brain-inspired functionality.

On 12 October, the White House published its report on the future of artificial intelligence (AI) - a product of four workshops held between May and July 2016 in Seattle, Pittsburgh, Washington DC and New York City (see go.nature.com/2dx8rv6).

Machines powered by artificial intelligence increasingly mediate our social, cultural, economic and political interactions. Understanding the behaviour of artificial intelligence systems is essential to our ability to control their actions, reap their benefits and minimize their harms. Here we argue that this necessitates a broad scientific research agenda to study machine behaviour that incorporates and expands upon the discipline of computer science and includes insights from across the sciences. We first outline a set of questions that are fundamental to this emerging field and then explore the technical, legal and institutional constraints on the study of machine behaviour. Understanding the behaviour of the machines powered by artificial intelligence that increasingly mediate our social, cultural, economic and political interactions is essential to our ability to control the actions of these intelligent machines, reap their benefits and minimize their harms.

Researchers are excited but apprehensive about the latest advances in artificial intelligence. Researchers are excited but apprehensive about the latest advances in artificial intelligence.

Current BCI technology is mainly focused on therapeutic outcomes, such as helping people with spinal-cord injuries. It might take years or even decades until BCI and other neurotechnologies are part of our daily lives. Such advances could revolutionize the treatment of many conditions, from brain injury and paralysis to epilepsy and schizophrenia, and transform human experience for the better. But the technology could also exacerbate social inequalities and offer corporations, hackers, governments or anyone else new ways to exploit and manipulate people.

Traditional pathology approaches have played an integral role in the delivery of diagnosis, semi-quantitative or qualitative assessment of protein expression, and classification of disease. Technological advances and the increased focus on precision medicine have recently paved the way for the development of digital pathology-based approaches for quantitative pathologic assessments, namely whole slide imaging and artificial intelligence (AI)–based solutions, allowing us to explore and extract information beyond human visual perception. Within the field of immuno-oncology, the application of such methodologies in drug development and translational research have created invaluable opportunities for deciphering complex pathophysiology and the discovery of novel biomarkers and drug targets. With an increasing number of treatment options available for any given disease, practitioners face the growing challenge of selecting the most appropriate treatment for each patient. The ever-increasing utilization of AI-based approaches substantially expands our understanding of the tumor microenvironment, with digital approaches to patient stratification and selection for diagnostic assays supporting the identification of the optimal treatment regimen based on patient profiles. This review provides an overview of the opportunities and limitations around implementing AI-based methods in biomarker discovery and patient selection and discusses how advances in digital pathology and AI should be considered in the current landscape of translational medicine, touching on challenges this technology may face if adopted in clinical settings. The traditional role of pathologists in delivering accurate diagnoses or assessing biomarkers for companion diagnostics may be enhanced in precision, reproducibility, and scale by AI-powered analysis tools.