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"Autisme."
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The autists : women on the spectrum
An incisive and deeply candid account that explores autistic women in culture, myth, and society through the prism of the author's own diagnosis. Until the 1980s, autism was regarded as a condition found mostly in boys. Even in our time, autistic girls and women have largely remained invisible. When portrayed in popular culture, women on the spectrum often appear simply as copies of their male counterparts -- talented and socially awkward. Yet autistic women exist, and always have. They are varied in their interests and in their experiences. Autism may be relatively new as a term and a diagnosis, but not as a way of being and functioning in the world. It has always been part of the human condition. So who are these women, and what does it mean to see the world through their eyes? In The Autists, Clara Törnvall reclaims the language to describe autism and explores the autistic experience in arts and culture throughout history. From popular culture, films, and photography to literature, opera, and ballet, she dares to ask what it might mean to re-read these works through an autistic lens -- what we might discover if we allow perspectives beyond the neurotypical to take centre stage.
Book
Autism in Film and Television
Global awareness of autism has skyrocketed since the 1980s, and
popular culture has caught on, with film and television producers
developing ever more material featuring autistic characters.
Autism in Film and Television brings together more than a
dozen essays on depictions of autism, exploring how autistic
characters are signified in media and how the reception of these
characters informs societal understandings of autism.
Editors Murray Pomerance and R. Barton Palmer have assembled a
pioneering examination of autism's portrayal in film and
television. Contributors consider the various means by which autism
has been expressed in films such as Phantom Thread,
Mercury Rising , and Life Animated and in
television and streaming programs including Atypical ,
Stranger Things , Star Trek: The Next Generation ,
and Community . Across media, the figure of the brilliant,
accomplished, and \"quirky\" autist has proven especially appealing.
Film and television have thus staked out a progressive position on
neurodiversity by insisting on screen time for autism but have done
so while frequently ignoring the true diversity of autistic
experience. As a result, this volume is a welcome celebration of
nonjudgmental approaches to disability, albeit one that is still
freighted with stereotypes and elisions.
eBook
Magnificent minds : the new whole-child approach to autism
\"An estimated one in thirty-six children in the United States is diagnosed with autism. New research has shed light on the many factors that determine a child's trajectory-but many parents are still navigating this complex terrain without a road map. Pediatric neurologist Dr. Suzanne Goh has spent decades working with autistic children, and in this practical and research-based guide she shares her renowned and revolutionary model of care: an innovative, whole-child approach that combines optimal medical treatment with the most effective strategies for advancing cognition, communication, and behavior. Demystifying a wide range of diagnostics and therapies and offering new insights into the neurological, biochemical, behavioral, and social factors that play a role in successful outcomes, the book is an essential resource for understanding all of autism-a strengths-based approach that helps parents design a comprehensive treatment plan. It is also a celebration of what each autistic person brings to the world-and how parents can best nurture the remarkable uniqueness of their child while setting them up for the future they envision\"-- Provided by publisher.
Book
Autistic Adults
An accessible and comprehensive look at autistic adults, written with an aim towards understanding and empathy.Most research and writing about autism is focused on children, although most autistic people are adults.
eBook
Autism and Worship
In churches today, those on the autism spectrum are often at best overlooked by neurotypical church members or at worst infantilized. Viewed as \"other,\" autistic people who feel excluded from the church community abound, and statistics show that they are less likely to attend church than others. Other autistic people do participate in worship but testify to being dismissed when asking for \"reasonable accommodations,\" and they are routinely given fewer formal roles in the liturgy.
In Autism and Worship, Armand Léon van Ommen offers an in-depth analysis of the absence and ignoring of, but also the presence of, autistic people in worship. Van Ommen recounts the experiences of autistic people and considers how those experiences might reframe liturgical theology and the worship practices of the church. He identifies the \"cult of normalcy\" as the root of the marginalization of autistic people. Normalcy is boundary keeping, the protective set of dynamics that determines who belongs to the community and who is excluded. The answer to absence and ignoring is found in presence and availability, rooted in kenosis. Through the act of making himself available to humankind by becoming human, Christ participated in humanity. Believers are invited to participate in the life and prayer of Christ in turn and accordingly make themselves available to one another.
The new identity in Christ redefines what is deemed normal and redefines who is \"in\" or \"out.\" Van Ommen argues that this redefinition results from a kenotic liturgical theology of availability. He illustrates this fresh vision by analyzing the Chapel of Christ Our Hope, a church in Singapore that is centered on autism and provides a paradigm for a renewal of Christian worship. Autism and Worship contributes to liturgical theology and the emerging field of autism theology as well as the practices of worshiping communities.
eBook
Across the Spectrum: A Journey Towards Understanding and Supporting Individuals With Autism
Autism spectrum disorder (ASD) presents itself in many different ways, and teachers must be able to identify individual and shared characteristics to provide proper support. This can often present problems for teachers who lack experience of working with children across the entire spectrum, which ranges from supporting those with severe learning difficulties to working with highly able young people.Using real-life examples from their decades of experience, Francine Brower and Keith MacKenzie Cox explain how to identify diverse characteristics of autism and explore key challenges that individuals and schools face. With an emphasis on practical solutions, they offer a wealth of creative strategies and interventions perfect for any setting, from tapping into special interests and establishing routines to developing social skills.Covering a range of autism presentations, including sensory differences, communication, behaviour and socialisation, this is the ideal book for mainstream and special school teachers looking to improve their special educational needs provision, and develop the best possible learning outcomes for all pupils on the autism spectrum.
eBook
An annotated introductory reading list for neurodiversity
Since its inception, the concept of neurodiversity has been defined in a number of different ways, which can cause confusion among those hoping to educate themselves about the topic. Learning about neurodiversity can also be challenging because there is a lack of well-curated, appropriately contextualized information on the topic. To address such barriers, we present an annotated reading list that was developed collaboratively by a neurodiverse group of researchers. The nine themes covered in the reading list are: the history of neurodiversity; ways of thinking about neurodiversity; the importance of lived experience; a neurodiversity paradigm for autism science; beyond deficit views of ADHD; expanding the scope of neurodiversity; anti-ableism; the need for robust theory and methods; and integration with open and participatory work. We hope this resource can support readers in understanding some of the key ideas and topics within neurodiversity, and that it can further orient researchers towards more rigorous, destigmatizing, accessible, and inclusive scientific practices.
Journal Article
Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders
Background
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with high heritability. Recent findings support a highly heterogeneous and complex genetic etiology including rare
de novo
and inherited mutations or chromosomal rearrangements as well as double or multiple hits.
Methods
We performed whole-exome sequencing (WES) and blood cell transcriptome by RNAseq in a subset of male patients with idiopathic ASD (
n
= 36) in order to identify causative genes, transcriptomic alterations, and susceptibility variants.
Results
We detected likely monogenic causes in seven cases: five
de novo
(
SCN2A
,
MED13L
,
KCNV1
,
CUL3
, and
PTEN
) and two inherited X-linked variants (
MAOA
and
CDKL5
). Transcriptomic analyses allowed the identification of intronic causative mutations missed by the usual filtering of WES and revealed functional consequences of some rare mutations. These included aberrant transcripts (
PTEN
,
POLR3C
), deregulated expression in 1.7% of mutated genes (that is,
SEMA6B
,
MECP2
,
ANK3
,
CREBBP
), allele-specific expression (
FUS
,
MTOR
,
TAF1C
), and non-sense-mediated decay (
RIT1
,
ALG9
). The analysis of rare inherited variants showed enrichment in relevant pathways such as the PI3K-Akt signaling and the axon guidance.
Conclusions
Integrative analysis of WES and blood RNAseq data has proven to be an efficient strategy to identify likely monogenic forms of ASD (19% in our cohort), as well as additional rare inherited mutations that can contribute to ASD risk in a multifactorial manner. Blood transcriptomic data, besides validating 88% of expressed variants, allowed the identification of missed intronic mutations and revealed functional correlations of genetic variants, including changes in splicing, expression levels, and allelic expression.
Journal Article