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Ashley Rubens, winner of the competition to find the BVA member facing the toughest driving conditions in the UK, has spent the past few months putting a Subaru Outback through its paces.Ashley Rubens, winner of the competition to find the BVA member facing the toughest driving conditions in the UK, has spent the past few months putting a Subaru Outback through its paces.

Zoe Davies, BVA's marketing manager, invites members to take up the Subaru challenge.

As the manufacturing time, quality, and cost associated with additive manufacturing (AM) continue to improve, more and more businesses and consumers are adopting this technology. Some of the key benefits of AM include customizing products, localizing production and reducing logistics. Due to these and numerous other benefits, AM is enabling a globally distributed manufacturing process and supply chain spanning multiple parties, and hence raises concerns about the reliability of the manufactured product. In this work, we first present a brief overview of the potential risks that exist in the cyber-physical environment of additive manufacturing. We then evaluate the risks posed by two different classes of modifications to the AM process which are representative of the challenges that are unique to AM. The risks posed are examined through mechanical testing of objects with altered printing orientation and fine internal defects. Finite element analysis and ultrasonic inspection are also used to demonstrate the potential for decreased performance and for evading detection. The results highlight several scenarios, intentional or unintentional, that can affect the product quality and pose security challenges for the additive manufacturing supply chain.

Observation: İatrogenic Cushing syndrome is caused by prolonged exogenous administration of glucocorticoid hormones. Long term use of topical corticosteroids, especially in children, may cause Cushing syndrome and suppression of the hypothalamopituitory-adrenal axis, which is less common than that of oral or parenteral usage. Michelin tire baby is a rare genetic disease characterized by generalized skin folding. At birth, circumferential skin fold is a rare sign. In patients one or few folds around the limbs may exist and these folds revealed amniotic band constrictions. . We report this case to highlight that iatrogenic Cushing syndrome in a child can mimic Michelin Tire-Baby syndrome.

Spirochetes are a widespread group of bacteria with a distinct morphology. Some spirochetes are important human pathogens that utilize periplasmic flagella to achieve motility and host infection. The motors that drive the rotation of periplasmic flagella have a unique spirochete-specific feature, termed the collar, crucial for the flat-wave morphology and motility of the Lyme disease spirochete Borrelia burgdorferi . Here, we deploy cryo-electron tomography and subtomogram averaging to determine high-resolution in-situ structures of the B . burgdorferi flagellar motor. Comparative analysis and molecular modeling of in-situ flagellar motor structures from B . burgdorferi mutants lacking each of the known collar proteins (FlcA, FlcB, FlcC, FlbB, and Bb0236/FlcD) uncover a complex protein network at the base of the collar. Importantly, our data suggest that FlbB forms a novel periplasmic ring around the rotor but also acts as a scaffold supporting collar assembly and subsequent recruitment of stator complexes. The complex protein network based on the FlbB ring effectively bridges the rotor and 16 torque-generating stator complexes in each flagellar motor, thus contributing to the specialized motility and lifestyle of spirochetes in complex environments.

PurposeFollowing surgery for lumbar spinal stenosis (LSS) up to 40% of people report persistent walking disability. This study aimed to identify pre-operative factors that are predictive of walking ability post-surgery for LSS.MethodsAn observational cohort study was conducted using data from the British Spine Registry (2017–2018) of adults (≥ 50 years) with LSS, who underwent ≤ 2 level posterior lumbar decompression. Patients receiving fixation or who had previous lumbar surgery were excluded. Walking ability was assessed by a single item on the Oswestry Disability Index and dichotomised into poor/good outcome. Multivariable regression models were performed.Results14,485 patients were identified. Pre-operatively 30% patients reported poor walking ability, this decreased to 8% at 12 months follow-up. Predictors associated with poor walking ability at 12 months were: increasing age (≥ 75 years OR 1.54, 95% CI 1.07, 2.18), BMI ≥ 35 kg/m2 (OR 1.52, 95% CI 1.00, 2.30), severity of leg pain (OR 1.10, CI 95% 1.01, 1.21), disability (OR 1.01, 95% CI 1.01, 1.02) and quality of life (OR 0.72, 95% CI 0.56, 0.89). Pre-operative maximum walking distance (OR 1.10, 95% CI 1.05, 1.25) and higher education (OR 0.90, 95% CI 0.80, 0.96) were associated with reduced risk of poor walking ability at 12 months; p < 0.05. Depression, fear of movement and symptom duration were not associated with risk of poor outcome.ConclusionOlder age, obesity, greater pre-operative pain and disability and lower quality of life are associated with risk of poor walking ability post-operatively. Greater pre-operative walking and higher education are associated with reduced risk of poor walking ability post-operatively. Patients should be counselled on their risk of poor outcome and considered for rehabilitation so that walking and surgical outcomes may be optimised.

AUTOMOTIVE DESIGN The shroud of mystery that's surrounded Faraday Future, the Los Angelesbased electric carmaker backed by Chinese billionaire Jai Yueting, lifted a bit during last month's Consumer Electronics Show in Las Vegas.

The new generation of smart highway (NGSH) has become an irresistible global trend to improve transport efficiency and safety. The exploration of the features and framework for NGSH can guide us to upgrade the current highway system. This paper summarizes the fundamental features of the NGSH from the perspective of the interactive evolution of automobile industry and road transport. In line with the popularity of automated and connected vehicles, the primary technical features of the NGSH are proposed as (I) complete elements sensing, (II) cyber-physical systems, (III) cooperative vehicle-infrastructure applications, and (IV) 5th generation mobile communication technology. The corresponding physical framework and data flow are introduced, in which three data attributes (data accuracy, dimensionality, and freshness) are highlighted to describe the data requirements for various scenarios. The development path of the NGSH is further discussed in terms of the different vehicle automation levels. The characteristics of five levels of NGSH are identified from R1 to R5. Different combinations of NGSH level and vehicle automation level lead to distinct system functions. Several urgent problems in the current stage are pointed out in terms of system compatibility, standard specification, and information security. This paper provides new insights for sustainable and reproducible highway reformation, drawing some implications for NGSH design.