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A coherent terahertz (THz) link at 200 GHz , with a variable data rate up to 11 Gbit/s, featuring a very high sensitivity at the receiver, is investigated. The system uses a quasi-optic unitravelling carrier photodiode (UTC-PD) emitter and an electronic receiver. The coherent link relies on an optical frequency comb generator at the emission to produce an optical beat note with 200 GHz separation, phase-locked with the receiver. Bit error ratio testing has been carried out using an indoor link configuration, and error-free operation is obtained up to 10 Gbit/s with a received power <2 µW.

The prefrontal cortex (PCx) is involved in many higher-order cognitive processes, including decision making, reasoning, personality expression, and social cognition. These functions are associated with high energy demand and the production of harmful oxygen radicals. Recent studies indicate that kynurenic acid (KYNA) exerts neuroprotective effects, largely due to its anti-inflammatory and antioxidant properties. To further evaluate the antioxidant potential of this compound, we tested the hypothesis that increasing KYNA levels in the sheep cerebroventricular circulation would positively affect the mRNA expression and activity of selected antioxidant and DNA repair enzymes in the distal part of the brain, i.e., the PCx. Anestrous sheep were infused intracerebroventricularly with a series of two KYNA doses: lower (4 × 5 μg/60 μL/30 min) and higher (4 × 25 μg/60 μL/30 min) at 30 min intervals. The results demonstrated that KYNA exerted significant dose-dependent stimulatory effects on the activity of superoxide dismutase 2, catalase, and glutathione peroxidase 1 while inhibiting their transcription in a similar manner. In addition, KYNA was also found to dose-dependently activate the base excision repair pathway, as determined by the increased transcript levels of glycosylases: N-methylpurine DNA glycosylase, thymine-DNA glycosylase, 8-oxoguanine DNA glycosylase-1, and apurinic/apyrimidinic endonuclease 1. The excision efficiency of damaged nucleobases, such as εA, εC and 8-oxoG, by these enzymes was also increased in response to central KYNA infusion. These findings expand the knowledge on KYNA as a potential protective factor against oxidative stress in the central nervous system.

The research in underwater communication system is focused towards wireless networks in view of recent developments in wireless technology and increasing need for deep sea data mining. The underwater wireless optical communication (UWOC) have more advantages for short-range wireless links due to very high bandwidth and data rate than acoustic communication. Although UWOC offers high capacity links at low latencies, they suffer from limited communication range due to various distinctive characteristics of underwater channel. A major degrading effect associated with the underwater channel is turbulence-induced fading. To mitigate this fading and to extend the viable communication range, spatial multipath diversity techniques can be adopted over UWOC links. The proposed work evaluates the performance of a multicarrier modulation scheme, i.e., MIMO based DC biased Optical Orthogonal Frequency Division Multiplexing (DCO-OFDM) for underwater wireless optical channel. The simulation of MIMO-DC biased optical OFDM technique employing spatial diversity in underwater optical communication is a novel approach towards the determination of an optimal modulation technique for underwater optical wireless channels. The performance is evaluated based on the various parameters such as Signal to Interference plus Noise Ratio (SINR), Throughput and Bit Error Rate (BER). A simple experiment is conducted to demonstrate the BER performance assessment for different link distance of 0.45 m and 1.5 m with different transmitter and receiver configurations (SIMO and MIMO) for both clear water and coastal water using MIMO DCO OFDM technique.

In this work, we adopt the analysis of a heterogeneous cellular network by means of stochastic geometry, to estimate energy and spectral network efficiency. More specifically, it has been the widely spread experience that practical field assessment of the Signal-to-Noise and Interference Ratio (SINR), being the key physical-layer performance indicator, involves quite sophisticated test instrumentation that is not always available outside the lab environment. So, in this regard, we present here a simpler test model coming out of the much easier-to-measure Bit Error Rate (BER), as the latter can deteriorate due to various impairments regarded here as equivalent with additive white Gaussian noise (AWGN) abstracting (in terms of equal BER degradation) any actual non-AWGN impairment. We validated the derived analytical model for heterogeneous two-tier networks by means of an ns3 simulator, as it provided the test results that fit well to the analytically estimated corresponding ones, both indicating that small cells enable better energy and spectral efficiencies than the larger-cell networks.

Objective: To investigate the contribution of MYH associated polyposis coli (MAP) among polyposis families in the Netherlands, and the prevalence of colonic and extracolonic manifestations in MAP patients. Methods: 170 patients with polyposis coli, who previously tested negative for APC mutations, were screened by denaturing gradient gel electrophoresis and direct sequencing to identify MYH germline mutations. Results: Homozygous and compound heterozygous MYH mutations were identified in 40 patients (24%). No difference was found in the percentage of biallelic mutation carriers between patients with 10–99 polyps or 100–1000 polyps (29% in both groups). Colorectal cancer was found in 26 of the 40 patients with MAP (65%) within the age range 21 to 67 years (median 45). Complete endoscopic reports were available for 16 MAP patients and revealed five cases with gastro-duodenal polyps (31%), one of whom also presented with a duodenal carcinoma. Breast cancer occurred in 18% of female MAP patients, significantly more than expected from national statistics (standardised morbidity ratio = 3.75). Conclusions: Polyp numbers in MAP patients were equally associated with the attenuated and classical polyposis coli phenotypes. Two thirds of the MAP patients had colorectal cancer, 95% of whom were older than 35 years, and one third of a subset of patients had upper gastrointestinal lesions. Endoscopic screening of the whole intestine should be carried out every two years for all MAP patients, starting from age 25–30 years. The frequent occurrence of additional extraintestinal manifestations, such as breast cancer among female MAP patients, should be thoroughly investigated.

We are presenting the initial results of inverted internal limiting membrane (ILM) flap technique for large macular hole. Five eyes of five patients with large diameter macular hole (>700 μm) were selected. All patients underwent inverted ILM flap technique for macular hole. Anatomical closure and functional success were achieved in all patients. There was no loss of best-corrected visual acuity in any of the patients. Inverted ILM flap technique in macular hole surgery seems to have a better hole closure rates, especially in large diameter macular holes. Larger case series is required to assess the efficacy and safety of this technique.

In this retrospective case series, we studied the predisposing factors, causative organisms, clinical spectrum, and outcomes of 12 cases of culture-proven infectious scleritis. Nine of 12 patients had a history of preceding trauma (surgical or accidental). Past surgical history included small-incision cataract surgery (4), pterygium surgery (1), and trabeculectomy (1). Six patients had multifocal scleral abscesses due to Pseudomonas, Klebsiella, or Nocardia. Only 2 patients retained useful vision (>6/18). A poor visual acuity at presentation usually resulted in a worse visual outcome (P = 0.005). Four eyes developed phthisis. The addition of surgical intervention did not result in a significantly better visual outcome than medical management alone (P = 0.209), but resulted in a higher globe preservation rate (P = 0.045). Therefore, we concluded that infection must be ruled out in cases of scleritis with preceding history of trauma, and aggressive surgical intervention improves the anatomical outcome but does not change the visual outcome.

Graft-versus-host disease (GVHD) is a frequent complication after hematopoietic cell transplant (HCT). Tissue damage as a result of chemoradiation injury is the initiating event in the pathogenesis of acute GVHD. Variations in DNA repair can influence the amount of tissue damage in response to alkylating agents and ionizing radiation used as conditioning during HCT. As DNA damage caused by these agents is repaired by the base excision repair (BER) pathway, we hypothesized that single-nucleotide polymorphisms (SNPs) in BER pathway will be associated with GVHD after HCT. Hence, we analyzed 179 SNPs in BER pathway in 470 recipients of allogeneic HCT for association with acute and chronic GVHD. In multivariate analysis, one SNP (rs6844176) in RFC1 (replication factor C (activator 1)) gene was independently associated with a higher risk of grade II–IV acute GVHD (relative risk (RR): 1.39, 95% confidence interval (CI): 1.14–1.70, P =0.001), and showed a trend toward higher risk of grade III–IV acute GVHD (RR: 1.33, 95% CI: 0.95–1.85, P =0.09). One SNP in PARP1 gene (rs1805410) was associated with a higher risk of chronic GVHD (RR: 1.81, 95% CI: 1.29–2.54, P =0.001). These results show that SNPs in the BER pathway can be used as genetic biomarkers to predict those at high risk for GVHD toward whom novel prophylactic strategies could be targeted.

Congenital eyelid imbrication syndrome (CEIS) is an extremely rare, benign, transient, self-limiting eyelid malposition disorder. The classic triad of signs in patients with a CEIS consists of bilateral upper eyelids overriding the lower eyelids when child was in sleep, bilateral medial and lateral canthal tendon laxity and tarsal conjunctival hyperemia. We report a third case of congenital combined eyelid imbrication and floppy eyelid syndrome in healthy neonate that was resolved within a week with conservative treatment.