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Critical Neuroscience: A Handbook of the Social and Cultural Contexts of Neuroscience brings together multi-disciplinary scholars from around the world to explore key social, historical and philosophical studies of neuroscience, and to analyze the socio-cultural implications of recent advances in the field. This text's original, interdisciplinary approach explores the creative potential for engaging experimental neuroscience with social studies of neuroscience while furthering the dialogue between neuroscience and the disciplines of the social sciences and humanities. Critical Neuroscience transcends traditional skepticism, introducing novel ideas about 'how to be critical' in and about science.

Drawing from the works of Dante, Catherine of Siena, Boccaccio, Aquinas, and Cavalcanti and other literary, philosophic, and scientific texts, Heather Webb studies medieval notions of the heart to explore the \"lost circulations\" of an era when individual lives and bodies were defined by their extensions into the world rather than as self-perpetuating, self-limited entities.

This book is a unique treatment manual which looks at the assessment of BDD, offering an treatment model in the form of CBT and pharmacotherapy Summarises the current knowledge and theoretical perspectives about BDD Covers the practical aspects of assessment, engagement, and therapy Uses a number of practical resources, including client handouts.

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci ( P  < 5 × 10 −8 ), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis. Genetic correlates of obesity In the second of two Articles in this issue from the GIANT Consortium, Elizabeth Speliotes and collegues conducted a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), commonly used to define obesity and assess adiposity, to find 97 BMI-associated loci, of which 56 were novel. Many of these loci have significant effects on other metabolic phenotypes. The 97 loci account for about 2.7% of BMI variation, and genome-wide estimates suggest common variation accounts for more than 20% of BMI variation. Pathway analyses implicate the central nervous system in obesity susceptibility including synaptic function, glutamate signaling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated α-synuclein in Lewy bodies and Lewy neurites in the central and peripheral nervous systems. The brains of patients with LBD often display other comorbid pathologies, i.e. insoluble tau, β-amyloid aggregates, TAR DNA-binding protein 43 (TDP-43) deposits, and argyrophilic grain disease (AGD). The incidence and physiological relevance of these concurrent pathological findings remain controversial. We performed a semiquantitative detailed mapping of α-synuclein, tau, β-amyloid (Aβ), TDP-43, and AGD pathologies in 17 areas in 63 LBD cases (44 with Parkinson disease [PD], 28 with dementia, and 19 with dementia with Lewy bodies). APOE and MAPT genetic variants were also investigated. A majority of LBD cases had 2 or 3 concomitant findings, particularly Alzheimer disease-related pathology. Pathological stages of tau, β-amyloid and α-synuclein pathologies were increased in cases with dementia. Aβ score was the best correlate of the time to dementia in PD. In addition, β-amyloid deposition correlated with α-synuclein load in all groups. MAPT H1 haplotype did not influence any assessed pathology in PD. These results highlight the common concurrence of pathologies in patients with LBD that may have an impact on the clinical expression of the diseases.

The heart is the most symbolic organ of the human body. Across cultures it is seen as the site of emotions, as well as the origin of life. We feel emotions in the heart, from the heart-stopping sensation of romantic love to the crushing sensation of despair. And yet since the nineteenth century the heart has been redefined in medical terms as a pump, an organ responsible for the circulation of the blood. Emotions have been removed from the heart as an active site of influence and towards the brain. It is the brain that is the organ most commonly associated with emotion in the modern West. So why, then, do the emotional meanings of the heart linger? Why do many transplantation patients believe that the heart, for instance, can transmit memories and emotions and why do we still refer to emotions as ‘heartfelt’? We cannot answer these questions without reference to the history of the heart as both physical organ and emotional symbol. Matters of the Heart traces the ways emotions have been understood between the seventeenth and nineteenth centuries as both physical entities and spiritual experiences. With reference to historical interpretations of such key concepts as gender, emotion, subjectivity, and the self, it also addresses the shifting relationship from heart to brain as competing centres of emotion in the West.

Are you ripped? Do you need to work on your abs? Do you know your ideal body weight? Your body fat index? Increasingly, Americans are being sold on a fitness ideal - not just thin but toned, not just muscular but cut - that is harder and harder to reach. In Body Panic, Shari L. Dworkin and Faye Linda Wachs ask why. How did these particular body types come to be \"fit\"? And how is it that having an unfit, or \"bad,\" body gets conflated with being an unfit, or \"bad,\" citizen?Dworkin and Wachs head to the newsstand for this study, examining ten years worth of men's and women's health and fitness magazines to determine the ways in which bodies are \"made\" in today's culture. They dissect the images, the workouts, and the ideology being sold, as well as the contemporary links among health, morality, citizenship, and identity that can be read on these pages. While women and body image are often studied together, Body Panic considers both women's and men's bodies side-by-side and over time in order to offer a more in-depth understanding of this pervasive cultural trend.

Der Band versammelt Beiträge zur philosophischen Erklärung der Beziehung zwischen Körper und Seele in der Antike von den Vorsokratikern bis Galen. Er enthält Beiträge über das Denken bei Parmenides (E. Hussey, R. Dilcher), die Liebe bei Empedokles (D. O'Brien), die Dreiteilung der Seele bei Platon (T. Buchheim), Aristoteles – vor allem die Parva Naturalia – (C. Rapp, T. Johansen, P.-M. Morel), nacharistotelische Peripatetiker (R. Sharples), hellenistische Philosophie (C. Rapp, C. Gill) und Galen (R. J. Hankinson). Der Titel spielt auf einen Ausdruck bei Platon, Aristoteles und Plotin an, der sich auf Aspekte des Lebendigseins an Körper und Seele bezieht und ein Topos in der antiken Philosophie wurde, der bei den verschiedenen Autoren unterschiedlich behandelt wurde.

To be fat hasn't always occasioned the level of hysteria that this condition receives today and indeed was once considered an admirable trait. Fat Shame: Stigma and the Fat Body in American Culture explores this arc, from veneration to shame, examining the historic roots of our contemporary anxiety about fatness. Tracing the cultural denigration of fatness to the mid 19th century, Amy Farrell argues that the stigma associated with a fat body preceded any health concerns about a large body size. Firmly in place by the time the diet industry began to flourish in the 1920s, the development of fat stigma was related not only to cultural anxieties that emerged during the modern period related to consumer excess, but, even more profoundly, to prevailing ideas about race, civilization and evolution. For 19th and early 20th century thinkers, fatness was a key marker of inferiority, of an uncivilized, barbaric, and primitive body. This idea--that fatness is a sign of a primitive person--endures today, fueling both our $60 billion war on fat and our cultural distress over the obesity epidemic. Farrell draws on a wide array of sources, including political cartoons, popular literature, postcards, advertisements, and physicians' manuals, to explore the link between our historic denigration of fatness and our contemporary concern over obesity. Her work sheds particular light on feminisms' fraught relationship to fatness. From the white suffragists of the early 20th century to contemporary public figures like Oprah Winfrey, Monica Lewinsky, and even the Obama family, Farrell explores the ways that those who seek to shed stigmatized identities--whether of gender, race, ethnicity or class--often take part in weight reduction schemes and fat mockery in order to validate themselves as civilized. In sharp contrast to these narratives of fat shame are the ideas of contemporary fat activists, whose articulation of a new vision of the body Farrell explores in depth. This book is significant for anyone concerned about the contemporary war on fat and the ways that notions of the civilized body continue to legitimate discrimination and cultural oppression.

Time and the Science of the Soul in Early Modern Philosophy traces the complex and productive connections established between time and the soul from late Aristotelianism to the natural and political philosophy of Thomas Hobbes and René Descartes.