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Everything basketball
\"Basketball was invented in a Massachusetts gymnasium in the 1890s. Since then, it has grown into one of the world's most popular games. This title teaches readers about the sport's amazing history, legendary players, and the winning strategies that top teams use to succeed. The title features informative sidebars, exciting photos, a glossary, and an index. Aligned to Common Core Standards and correlated to state standards\"--Amazon.com.
BOOK
Art of the Interwoven
Appearing on this month’s cover is a jar-shaped basket created by Sara Hunter, who belonged to the Panamint Shoshone Tribe and was, according to the Cleveland Museum of Art, the last American Indian basket weaver to live in the Saline Valley on the edge of what is now Death Valley National Park in California. The US National Park service notes, “They hunted and followed seasonal migrations for harvesting of pinyon pine nuts and mesquite beans with their families. Later, as settlers, silver miners, and others moved into the region, the Portland Art Museum explains that “the fine quality of Panamint baskets created a collectors’ market, which lasted well into the mid-twentieth century.
Journal Article
There's always this year : on basketball and ascension
\"While Hanif Abdurraqib is an acclaimed author, a gifted poet, and one of our culture's most insightful music critics, he is most of all, at heart, an Ohioan. Growing up in Columbus in the '90s, Abdurraqib witnessed a golden era of basketball, one in which legends like LeBron were forged, and countless others weren't. His lifelong love of the game leads Abdurraqib into a lyrical, historical, and emotionally rich exploration of what it means to make it, who we think deserves success, the tensions between excellence and expectation, and the very notion of role-models, all of which he expertly weaves together with memoir: \"Here is where I would like to tell you about the form on my father's jumpshot,\" Abdurraqib writes. \"The truth, though, is that I saw my father shoot a basketball only one time.\"\"-- Provided by publisher.
Book
New clinical trial designs in the era of precision medicine
Cancer treatment has made significant strides towards the promise of personalized medicine. Recent scientific advances have shown that there are numerous genetic deregulations that are common in multiple cancer types, raising the possibility of developing drugs targeting those deregulations irrespective of the tumour type. Precision Cancer Medicine (PCM) was born out of accumulated evidence matching targeted agents with these tumour molecular deregulations. At the same time, the therapeutic armamentarium is rapidly increasing and the number of new drugs (including immune‐oncology agents) entering drug development continues to rise. These factors, added to strong collaboration with regulatory agencies, which have approved novel agents based on data obtained from phase 1/2 trials, have led to unprecedented evolution in the design of early‐stage clinical trials. Currently, we have seen rapid phase 1 dose‐escalation trials followed by remarkably large expansion cohorts, and are witnessing the emergence of new trials, such as adaptive studies with basket and umbrella designs aimed at optimizing the biomarker–drug co‐development process. Alongside the growing complexity of these clinical trials, new frameworks for stronger and faster collaboration between all stakeholders in drug development, including academic institutions and frameworks, clinicians, pharma companies and regulatory agencies, have been established. In this review article, we describe the main challenges and opportunities that these new trial designs may provide for a more efficient drug development process, which may ultimately help ensure that PCM becomes a reality for patients. New clinical trial designs are helping optimize early drug development. An umbrella trial is a master protocol for which the patient's eligibility is defined by the presence of a tumour type that is substratified according to specific molecular alterations matched to different anticancer therapies. Basket trials include patients with different tumour types with a common molecular alteration who are treated with the same matched therapy.
Journal Article
Diary of a wimpy kid : big shot
\"After a disastrous field day competition at school, Greg decides that when it comes to his athletic career, he's officially retired. But after his mom urges him to give sports one more chance, he reluctantly agrees to sign up for basketball. Tryouts are a mess, and Greg is sure he won't make the cut. But he unexpectedly lands a spot on the worst team. As Greg and his new teammates start the season, their chances of winning even a single game look slim. But in sports, anything can happen. When everything is on the line and the ball is in Greg's hands, will he rise to the occasion? Or will he blow his big shot?\"-- Provided by publisher.
Book
Letters
[...]it is seriously lacking in chronological depth, as is apparent from among the first books which I pulled from the shelves of Betty's and my library; see copies enclosed. [The writer enclosed several illustrations from The Art of Medieval Technology Images of Noah the Shipbuilder by Richard W Unger (New Brunswick, NJ.: Rutgers University Press) one of which is printed above.] Indeed, I am quite certain that baskets for tool carrying can be dated to the thirteen or possible twelfth century without a great deal of exertion.
Journal Article
Rez ball
\"These days, Tre Brun is happiest when he is playing basketball on the Red Lake Reservation high school team--even though he can't help but be constantly gut-punched with memories of his big brother, Jaxon, who died in an accident. When Jaxon's former teammates on the varsity team offer to take Tre under their wing, he sees this as his shot to represent his Ojibwe rez all the way to their first state championship. This is the first step toward his dream of playing in the NBA, no matter how much the odds are stacked against him. But stepping into his brother's shoes as a star player means that Tre can't mess up. Not on the court, not at school, and not with his new friend, gamer Khiana, who he is definitely not falling in love with. After decades of rez teams almost making it, Tre needs to take his team to state. Because if he can live up to Jaxon's dreams, their story isn't over yet\" -- Page [2] of cover.
Book
An Overview of Precision Oncology Basket and Umbrella Trials for Clinicians
With advancements in biomarkers and momentum in precision medicine, biomarker-guided trials such as basket trials and umbrella trials have been developed under the master protocol framework. A master protocol refers to a single, over-arching design developed to evaluate multiple hypotheses with the general goal of improving the efficiency of trial evaluation. One type of master protocol is the basket trial, in which a targeted therapy is evaluated for multiple diseases that share com-mon molecular alterations or risk factors that may help predict whether the patients will respond to the given therapy. Another variant of a master protocol is the umbrella trial, in which multiple targeted therapies are evaluated for a single disease that is stratified into multiple subgroups based on different molecular or other predictive risk factors. Both designs follow the core principle of precision medicine-to tailor intervention strategies based on the patient's risk factor(s) that can help predict whether they will respond to a specific treatment. There have been increasing num-bers of basket and umbrella trials, but they are still poorly understood. This article re-views common characteristics of basket and umbrella trials, key trials and recent US Food and Drug Administration approvals for precision oncology, and important con-siderations for clinical readers when critically evaluating future publications on bas-ket trials and umbrella trials and for researchers when designing these clinical trials.
Journal Article
Wrong side of the court
\"A young teen's world is changed when a friend is killed by gang violence, this novel is a coming-of-age story set against the backdrop of high school, communal violence, and budding romance.\"-- Provided by publisher.
Book
Monitoring Food Affordability: Reliability and Validity of an Online Nutritious Food Basket
Purpose: This study aimed to assess the reliability and validity of an online approach to monitoring food affordability in Ontario using the updated Ontario Nutritious Food Basket (ONFB). Methods: The ONFB was priced online in 12 large multi-chain grocery stores to test intra-/inter-rater reliability using percent agreement and intra-class correlations (ICCs). Then, the ONFB was priced in-store and online in 28 stores to estimate food price differences using paired t-tests and Pearson’s correlation for all (n =1708) and matched items (same product/brand and purchase unit) (n = 1134). Results: Intra-/inter-rater agreement was high (95.4%/81.6%; ICC = 0.972, F = 69.9, p < 0.001). On average, in-store prices were less than $0.02 lower than online prices. There were no significant differences between mean in-store and online prices for all items (t = 0.504 p = 0.614). The mean price was almost perfectly correlated between in-store and online (fully matched: R = 0.993 p < 0.001; all items: R = 0.967 p < 0.001). Online monthly ONFB estimates for a family of four were strongly correlated (R = 0.937 p < 0.001) with estimates calculated using in-store data. Conclusions: Online pricing is a reliable and valid approach to food costing in Ontario that contributes to modernizing the monitoring of food affordability in Canada and abroad.
Journal Article