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"Beads"
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Improvement strategy for the geometric accuracy of bead’s beginning and end parts in wire-arc additive manufacturing (WAAM)
Cold metal transfer (CMT)-based wire-arc additive manufacturing (WAAM) is a promising method for the production of large-scale and complex metallic parts because of its high efficiency, less heat input and low cost. However, a critical and common problem with the arc welding processes is the irregular geometry at the beginning and end parts of the bead due to the ignition and extinction of the arc. Based on experimental investigations of the irregularities and different possible optimization methods, an improvement strategy consisting of configurations with a varying travel speed and an extra return path is presented in this paper. Experimental results show that this strategy can effectively enhance the geometric accuracy at the beginning and end parts of different single beads. In the manufacturing of a thin-wall part and a multi-pass cladding, the improvement of geometric accuracy has also been achieved by this strategy.
Journal Article
Heterogeneous photoredox flow chemistry for the scalable organosynthesis of fine chemicals
Large-scale photochemical synthesis of high value chemicals under mild conditions is an ideal method of green chemical production. However, a scalable photocatalytic process has been barely reported due to the costly preparation, low stability of photosensitizers and critical reaction conditions required for classical photocatalysts. Here, we report the merging of flow chemistry with heterogeneous photoredox catalysis for the facile production of high value compounds in a continuous flow reactor with visible light at room temperature in air. In the flow reactor system, polymeric carbon nitrides, which are cheap, sustainable and stable heterogeneous photocatalysts, are immobilized onto glass beads and fibers, demonstrating a highly flexible construction possibility for devices of the photocatalytic materials. As an example of the production of high value chemicals, important chemical structures such as cyclobutanes, which are basic building blocks for many pharmaceutical compounds, like magnosalin, are synthesized in flow with high catalytic efficiency and stability.
Large-scale photochemical synthesis of high value chemicals is an ideal method of green chemical production. Here, the authors show the merging of heterogeneous carbon nitride photocatalysis with flow chemistry for the scalable organosynthesis of fine chemicals in a continuous flow reactor.
Journal Article
Kids craft with beads!
Introduces readers to the creative crafts they can make with beads. Projects include bead holiday decorations and a bowl made of multicolored beads. Readers will also learn how to make their very own unique bead jewelry. Each project includes a list of materials needed to complete the project, while step-by-step directions provide clear and helpful guidance. Pictures and illustrations allow readers to visualize each step in the bead project process. All you need are beads and an imagination to bring these creative crafts to life.
Book
Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection
Demand is strong for sensitive, reliable, and cost-effective diagnostic tools for cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising diagnostic platforms based on wide-ranging cancer biomarkers owing to the versatility, high sensitivity, and flexibility to perform the multiplexing of beads. This comprehensive review highlights recent trends and innovations in the development of bead-based biosensors for cancer-biomarker detection. We introduce various types of bead-based biosensors such as optical, electrochemical, and magnetic biosensors, along with their respective advantages and limitations. Moreover, the review summarizes the latest advancements, including fabrication techniques, signal-amplification strategies, and integration with microfluidics and nanotechnology. Additionally, the challenges and future perspectives in the field of bead-based biosensors for cancer-biomarker detection are discussed. Understanding these innovations in bead-based biosensors can greatly contribute to improvements in cancer diagnostics, thereby facilitating early detection and personalized treatments.
Journal Article
Ostrich eggshell bead strontium isotopes reveal persistent macroscale social networking across late Quaternary southern Africa
Hunter-gatherer exchange networks dampen subsistence and reproductive risks by building relationships of mutual support outside local groups that are underwritten by symbolic gift exchange. Hxaro, the system of delayed reciprocity between Ju/’hoãn individuals in southern Africa’s Kalahari Desert, is the best-known such example and the basis for most analogies and models of hunter-gatherer exchange in prehistory. However, its antiquity, drivers, and development remain unclear, as they do for long-distance exchanges among African foragers more broadly. Here we show through strontium isotope analyses of ostrich eggshell beads from highland Lesotho, and associated strontium isoscape development, that such practices stretch back into the late Middle Stone Age. We argue that these exchange items originated beyond the macroband from groups occupying the more water-stressed subcontinental interior. Tracking the emergence and persistence of macroscale, transbiome social networks helps illuminate the evolution of social strategies needed to thrive in stochastic environments, strategies that in our case study show persistence over more than 33,000 y.
Journal Article
Flora ad infinitum : Blühende Perlenkunst in Venedig und der Welt = Fiori di perline a Venezia e nel mondo
Glasperlen können auf Drähte aufgefädelt und zu Blumen geformt werden - ein historisches Kunsthandwerk, das in Venedig und dem berühmten Muranoglas beheimatet ist. In dem reich bebilderten Buch erzählt Georg Ragnar Levi die faszinierende Geschichte, wie es dazu kam, dass Perlenblumen geliebt und verachtet und irgendwann in der Geschichte sogar verboten wurden. Sogenannte Französische Perlenblumen wurden zu Hause, in Klöstern, Gefängnissen und Werkstätten hergestellt und bei Taufen, Hochzeiten und Beerdigungen zu ornamentalen und symbolischen Zwecken verwendet. Der Leser wird durch Historie, Techniken, Materialien und die persönlichen Geschichten hinter diesem Handwerk geführt. Levi zeigt, wie die Nachfrage nach Kränzen und Sträussen im frühen 20. Jh. zum Broterwerb vieler Familien in Europa wurde und die Glashütten von Murano und Böhmen aufblühen liess.
Book
Ultrasensitive proteome analysis using paramagnetic bead technology
In order to obtain a systems‐level understanding of a complex biological system, detailed proteome information is essential. Despite great progress in proteomics technologies, thorough interrogation of the proteome from quantity‐limited biological samples is hampered by inefficiencies during processing. To address these challenges, here we introduce a novel protocol using paramagnetic beads, termed Single‐Pot Solid‐Phase‐enhanced Sample Preparation (SP3). SP3 provides a rapid and unbiased means of proteomic sample preparation in a single tube that facilitates ultrasensitive analysis by outperforming existing protocols in terms of efficiency, scalability, speed, throughput, and flexibility. To illustrate these benefits, characterization of 1,000 HeLa cells and single
Drosophila
embryos is used to establish that SP3 provides an enhanced platform for profiling proteomes derived from sub‐microgram amounts of material. These data present a first view of developmental stage‐specific proteome dynamics in
Drosophila
at a single‐embryo resolution, permitting characterization of inter‐individual expression variation. Together, the findings of this work position SP3 as a superior protocol that facilitates exciting new directions in multiple areas of proteomics ranging from developmental biology to clinical applications.
Synopsis
A new proteomic sample preparation protocol allows fast, efficient and ultra‐sensitive analyses. The method is illustrated by profiling proteomes from sub‐microgram amounts of material, including the first proteome screen of
Drosophila
development at a single‐embryo resolution.
A novel protocol using paramagnetic beads, termed Single‐Pot Solid‐Phase‐enhanced Sample Preparation (SP3) is presented.
SP3 enables protein and peptide enrichment, cleanup, digestion, chemical isotope labeling and fractionation in a single tube, without limitations arising from reagent compatibility.
SP3 allows unmatched ultra‐sensitive proteome profiling from sub‐microgram amounts of material, as low as 1,000 HeLa cells or a single fly embryo.
The first quantitative analysis of early
Drosophila
development at a single‐embryo resolution reveals dynamic trends in the developmental proteome.
Graphical Abstract
A new proteomic sample preparation protocol allows fast, efficient and ultra‐sensitive analyses. The method is illustrated by profiling proteomes from sub‐microgram amounts of material, including the first proteome screen of
Drosophila
development at a single‐embryo resolution.
Journal Article