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Younger for life : feel great and look your best with the new science of autojuvenation
From best-selling author and social-media-star doctor comes a step-by-step guide to reversing the effects of aging at any stage in life.
Book
Life as Surplus
Focusing on the period between the 1970s and the present, Life as Surplus is a pointed and important study of the relationship between politics, economics, science, and cultural values in the United States today. Melinda Cooper demonstrates that the history of biotechnology cannot be understood without taking into account the simultaneous rise of neoliberalism as a political force and an economic policy. From the development of recombinant DNA technology in the 1970s to the second Bush administration's policies on stem cell research, Cooper connects the utopian polemic of free-market capitalism with growing internal contradictions of the commercialized life sciences.
The biotech revolution relocated economic production at the genetic, microbial, and cellular level. Taking as her point of departure the assumption that life has been drawn into the circuits of value creation, Cooper underscores the relations between scientific, economic, political, and social practices. In penetrating analyses of Reagan-era science policy, the militarization of the life sciences, HIV politics, pharmaceutical imperialism, tissue engineering, stem cell science, and the pro-life movement, the author examines the speculative impulses that have animated the growth of the bioeconomy.
At the very core of the new post-industrial economy is the transformation of biological life into surplus value. Life as Surplus offers a clear assessment of both the transformative, therapeutic dimensions of the contemporary life sciences and the violence, obligation, and debt servitude crystallizing around the emerging bioeconomy.
eBook
Outlive : the science & art of longevity
\"Wouldn't you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health. For all its successes, mainstream medicine has failed to make much progress against the diseases of aging that kill most people: heart disease, cancer, Alzheimer's disease, and type 2 diabetes. Too often, it intervenes with treatments too late to help, prolonging lifespan at the expense of healthspan, or quality of life. Dr. Attia believes we must replace this outdated framework with a personalized, proactive strategy for longevity, one where we take action now, rather than waiting. This is not 'biohacking,' it's science: a well-founded strategic and tactical approach to extending lifespan while also improving our physical, cognitive, and emotional health. Dr. Attia's aim is less to tell you what to do and more to help you learn how to think about long-term health, in order to create the best plan for you as an individual. In Outlive, readers will discover: Why the cholesterol test at your annual physical doesn't tell you enough about your actual risk of dying from a heart attack; that you may already suffer from an extremely common yet underdiagnosed liver condition that could be a precursor to the chronic diseases of aging; why exercise is the most potent pro-longevity 'drug'--and how to begin training for the 'Centenarian Decathlon\"; why you should forget about diets, and focus instead on nutritional biochemistry, using technology and data to personalize your eating pattern; why striving for physical health and longevity, but ignoring emotional health, could be the ultimate curse of all. Aging and longevity are far more malleable than we think; our fate is not set in stone. With the right roadmap, you can plot a different path for your life, one that lets you outlive your genes to make each decade better than the one before\"-- Provided by publisher.
Book
How robust are estimates of key parameters in standard viral dynamic models?
Mathematical models of viral infection have been developed, fitted to data, and provide insight into disease pathogenesis for multiple agents that cause chronic infection, including HIV, hepatitis C, and B virus. However, for agents that cause acute infections or during the acute stage of agents that cause chronic infections, viral load data are often collected after symptoms develop, usually around or after the peak viral load. Consequently, we frequently lack data in the initial phase of viral growth, i.e., when pre-symptomatic transmission events occur. Missing data may make estimating the time of infection, the infectious period, and parameters in viral dynamic models, such as the cell infection rate, difficult. However, having extra information, such as the average time to peak viral load, may improve the robustness of the estimation. Here, we evaluated the robustness of estimates of key model parameters when viral load data prior to the viral load peak is missing, when we know the values of some parameters and/or the time from infection to peak viral load. Although estimates of the time of infection are sensitive to the quality and amount of available data, particularly pre-peak, other parameters important in understanding disease pathogenesis, such as the loss rate of infected cells, are less sensitive. Viral infectivity and the viral production rate are key parameters affecting the robustness of data fits. Fixing their values to literature values can help estimate the remaining model parameters when pre-peak data is missing or limited. We find a lack of data in the pre-peak growth phase underestimates the time to peak viral load by several days, leading to a shorter predicted growth phase. On the other hand, knowing the time of infection (e.g., from epidemiological data) and fixing it results in good estimates of dynamical parameters even in the absence of early data. While we provide ways to approximate model parameters in the absence of early viral load data, our results also suggest that these data, when available, are needed to estimate model parameters more precisely.
Journal Article
Two-step pathway for isoprenoid synthesis
Isoprenoids comprise a large class of chemicals of significant interest due to their diverse properties. Biological production of isoprenoids is considered to be the most efficient way for their large-scale production. Isoprenoid biosynthesis has thus far been dependent on pathways inextricably linked to glucose metabolism. These pathways suffer from inherent limitations due to their length, complex regulation, and extensive cofactor requirements. Here, we present a synthetic isoprenoid pathway that aims to overcome these limitations. This isopentenol utilization pathway (IUP) can produce isopentenyl diphosphate or dimethylallyl diphosphate, the main precursors to isoprenoid synthesis, through sequential phosphorylation of isopentenol isomers isoprenol or prenol. After identifying suitable enzymes and constructing the pathway, we attempted to probe the limits of the IUP for producing various isoprenoid downstream products. The IUP flux exceeded the capacity of almost all downstream pathways tested and was competitive with the highest isoprenoid fluxes reported.
Journal Article
The life of super-Earths : how the hunt for alien worlds and artificial cells will revolutionize life on our planet
\"In the past year, we have witnessed unprecedented breakthroughs in the seemingly unrelated fields of synthetic biology and exoplanetary astronomy. Just recently, arsenic-based bacteria was discovered in a California lake-both puzzling and electrifying the scientific world. In The Life of Super-Earths, expert astronomer Dimitar Sasselov aims to highlight these groundbreaking findings and explain how what we learn in the laboratory informs our investigation of the universe, and vice versa. The discovery of a New Earth, or other world, may be in our future. But a truly 'alien' life form is more likely to emerge from our planet's natural environment or in a petri dish at a research lab. We may cross a milestone into the era of synthetic biology under the microscope. These breakthroughs will shed new light on our place in the universe and answer the age-old question: Are we alone in the universe? The Life of Super-Earths offers nothing short of a revolution in our understanding of life and its place in the cosmos\"-- Provided by publisher.
Book
The value of ecosystem services in global marine kelp forests
While marine kelp forests have provided valuable ecosystem services for millennia, the global ecological and economic value of those services is largely unresolved. Kelp forests are diminishing in many regions worldwide, and efforts to manage these ecosystems are hindered without accurate estimates of the value of the services that kelp forests provide to human societies. Here, we present a global estimate of the ecological and economic potential of three key ecosystem services - fisheries production, nutrient cycling, and carbon removal provided by six major forest forming kelp genera (
Ecklonia, Laminaria, Lessonia, Macrocystis, Nereocystis
, and
Saccharina
). Each of these genera creates a potential value of between $64,400 and $147,100/hectare each year. Collectively, they generate between $465 and $562 billion/year worldwide, with an average of $500 billion. These values are primarily driven by fisheries production (mean $29,900, 904 Kg/Ha/year) and nitrogen removal ($73,800, 657 Kg N/Ha/year), though kelp forests are also estimated to sequester 4.91 megatons of carbon from the atmosphere/year highlighting their potential as blue carbon systems for climate change mitigation. These findings highlight the ecological and economic value of kelp forests to society and will facilitate better informed marine management and conservation decisions.
By combining fisheries, nutrient, and carbon cycling data, this synthesis suggests that marine kelp forests, a dominant but often undescribed habitat, provide services with a potential value of $111,000/ha/year and a global yearly value of $500 billion.
Journal Article
The lost world of the dinosaurs : uncovering the secrets of the prehistoric age
An exploration into the world of dinosaurs, presented by paleontologist Armin Schmitt. Through firsthand experiences and groundbreaking research, Schmitt delves into the lives of these ancient creatures, showcasing global excavations and remarkable discoveries. While familiar favorites like Tyrannosaurus rex make appearances, Schmitt also addresses intriguing questions, such as the excavation process, the survival of birds during extinction events, the evolution of paleontology since the Bone Wars era, and parallels between past climate changes and contemporary environmental challenges.
BOOK
Critical Neuroscience
Critical Neuroscience: A Handbook of the Social and Cultural Contexts of Neuroscience brings together multi-disciplinary scholars from around the world to explore key social, historical and philosophical studies of neuroscience, and to analyze the socio-cultural implications of recent advances in the field. This text's original, interdisciplinary approach explores the creative potential for engaging experimental neuroscience with social studies of neuroscience while furthering the dialogue between neuroscience and the disciplines of the social sciences and humanities. Critical Neuroscience transcends traditional skepticism, introducing novel ideas about 'how to be critical' in and about science.
eBook